DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp68

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001157269.1	Gene:	Zfp68 / 24135	MGIID:	1344427	Length:	606	Species:	Mus musculus

Alignment Length:	637	Identity:	143/637 - (22%)
Similarity:	231/637 - (36%)	Gaps:	166/637 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NNSHFLDLHHPNCWPSEMAQIRLQFANWNLKISPNDGLPQKICSDCFTKFCSINAFRLACQEAQL 85
            |.|:.|.|.|....|..:..:..:..:|.::.|..       |...|....::|.     .....
Mouse    42 NYSNLLFLGHCKTKPELIFNLEQRLGSWIVEASHQ-------CVPDFQNMSTLNK-----SSPDT 94

  Fly    86 KLSHIYDKIDASSLEDDEIG--QEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIE--IFVD 146
            |..|:: ::..:|....|:.  ......:..|...:|.|         ..|:....|.:  ::.|
Mouse    95 KARHVW-QVALNSETSKELAGIGNTCNVSTNHISDQTIK---------NENSLGMSPRKFILWKD 149

  Fly   147 A---VDIDEAEEEEEEEEQQQQYDEEVEEPITDESA--PPQLTI-----SYACKFCLRPQENYQL 201
            .   .|.||.|..||.|:...          |.||.  |.|:::     |.:....|.|.:::..
Mouse   150 VYLHTDADEIEVGEEPEDLNG----------TAESVTHPEQVSLYRFQRSQSYFQSLIPGKSFNT 204

  Fly   202 QQLLLEH---------------------------------INAS----------HDPEQPYNCPE 223
            :.:||.|                                 ||.|          |..|:.|.|..
Mouse   205 KAVLLTHKFSEYAKSLGDTAFIDKEMAQIRVKSFECNVSEINCSKSDLNENEPTHMGEKHYKCSN 269

  Fly   224 CEARFQDAASRTVHLKSSH----VEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRF 284
            .|..|...:....| |..|    ::|::       ::..:..:..|.:....:..:||.:|.|.|
Mouse   270 FENPFIIESYLPKH-KGQHEKLFIQKEY-------EFSQQSEVSLHQKIRRGKKTYECKICGKCF 326

  Fly   285 YTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLK 349
            |.:.|.|.|...|..::.::|  :.|.:.|..:.||..|:..|:|   .:...|..|.|.|....
Mouse   327 YWKTSFNRHQSTHTGEKPYEC--TECSKAFCQKSHLTQHQRVHTG---ERPYICFECRKAFYRKS 386

  Fly   350 TLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLI 414
            .|..| .|.|.|||||:|..|.:.|                            |:     :|.|.
Mouse   387 ELTDH-QRIHTGEKPYECKECGKAF----------------------------CQ-----KPQLT 417

  Fly   415 HHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHA 479
            .|......::|                       ::|..|.:.|:.||.|..|...|: .::|:.
Mouse   418 LHQRIHTGEKP-----------------------YECAECGKAFSTKSYLTVHQRTHT-GEKPYE 458

  Fly   480 CPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAY 544
            |..|.|.|........|.:||..|||..|..|.|.|..|..||:|:.:| ..:|.::|.:|.:|:
Mouse   459 CTVCRKSFICKSSFSHHWRTHTGEKPYECKQCMKTFYRKSGLTRHQRTH-TGDKRYECQLCQKAF 522

  Fly   545 LFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            .....|.:|||||||:..|:|..|::.|.....||.| ||.|:..:...:.|
Mouse   523 YCTSHLIVHQRTHTGEKPYECKECRKAFYDKSNLKRH-QKIHSMKKASESKQ 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	11/65 (17%)
		COG5048	198..>508	CDD:227381	75/356 (21%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	1/19 (5%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Zfp68	NP_001157269.1	KRAB	10..70	CDD:214630	6/27 (22%)
		KRAB	10..49	CDD:279668	3/6 (50%)
		COG5048	<234..475	CDD:227381	66/311 (21%)
		C2H2 Zn finger	319..339	CDD:275368	8/19 (42%)
		zf-H2C2_2	331..354	CDD:290200	6/24 (25%)
		zf-C2H2	345..367	CDD:278523	6/23 (26%)
		C2H2 Zn finger	347..367	CDD:275368	6/21 (29%)
		C2H2 Zn finger	375..395	CDD:275368	7/20 (35%)
		zf-H2C2_2	387..410	CDD:290200	11/23 (48%)
		C2H2 Zn finger	403..423	CDD:275368	7/52 (13%)
		zf-H2C2_2	416..440	CDD:290200	6/46 (13%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		zf-H2C2_2	443..466	CDD:290200	7/23 (30%)
		C2H2 Zn finger	459..479	CDD:275368	5/19 (26%)
		C2H2 Zn finger	487..507	CDD:275368	8/19 (42%)
		COG5048	513..>586	CDD:227381	22/62 (35%)
		C2H2 Zn finger	515..535	CDD:275368	7/19 (37%)
		zf-H2C2_2	527..550	CDD:290200	11/22 (50%)
		zf-C2H2	541..563	CDD:278523	9/22 (41%)
		C2H2 Zn finger	543..563	CDD:275368	8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100