DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp53

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_038871.1	Gene:	Zfp53 / 24132	MGIID:	99200	Length:	652	Species:	Mus musculus

Alignment Length:	601	Identity:	156/601 - (25%)
Similarity:	243/601 - (40%)	Gaps:	99/601 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PSEMAQIRLQFAN---------WNLKISPNDGLPQKICSDCFTKFCSINAFRLACQEAQLKLSHI 90
            |..|:|..|.|.:         |....|....|...:..:.::...|:..:.::      ...|.
Mouse    46 PLIMSQRLLTFGDVAVEFPQEEWECLDSAQRALYIDVMLENYSNLVSVENYCIS------DTVHQ 104

  Fly    91 YDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEE 155
            :.|.:..|.:.:|:|:      ..|:.|.........:.||..|...|...:..||.::.|..:.
Mouse   105 HVKTEKESCQGNELGE------MLHEPTNCALYIRRDTIETSNNYRCSKDRDGSVDLLNQDRHKS 163

  Fly   156 EEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQ---------LQQLLLEHINA 211
            ....||..:  .|:.|:.::..|...:....||.. .|:.|..|.         :||.:
Mouse   164 THTGEELCK--SEDCEKSLSLSSNLTENQRLYAAN-KLQSQGEYDDDFSSVYSLMQQTI------ 219

  Fly   212 SHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFE 276
             :..:.|:.|.:|...|..|:|.|||.:....:|.:.|.||||.:....||:.|...:..|..::
Mouse   220 -YIGDTPHQCEKCRKCFSTASSLTVHKRIHTGKKPYKCSVCGKSFTQCTNLKTHQRLHTGEKPYK 283

  Fly   277 CALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGF- 340
            |..|.|.|....:|..|.|.|..:|.:||:.  |::.|........|:.||     |..|||..
Mouse   284 CKECGKSFPQLSALKSHQKIHTGERPYKCKE--CDKSFAHCSSFRRHQKTH-----RAEEHCSCP 341

  Fly   341 -CGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHM-------------------- 384
             |||....|..||.| ||.|.|||||||..|...|..||..|.|.
Mouse   342 ECGKVLHQLSHLRSH-YRLHTGEKPYKCNECDRSFTYYASYRRHQKTHSLDKFYKCKECGKSFLE 405

  Fly   385 ---LERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYS 446
               |:||....|..:..:|.:|.:.|:....|..|:.....::|
Mouse   406 LSHLKRHYRIHTGEKPYKCEVCDKSFTVNSTLKTHLKIHTGEKP--------------------- 449

  Fly   447 GLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVC 511
              |:|..|.:.|...|.|.||.:||: .::|:.|..|.|.|.....::.|.|.|..|||..|..|
Mouse   450 --FKCRECDKSFTKCSHLRRHQSVHT-GEKPYRCKECDKSFTECSTLRAHQKIHTGEKPYKCREC 511

  Fly   512 GKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHI 576
            .|:|..:..|..|:..| ..|:.:.|..||:::....:|::||:.|||:..|||..|.:.|....
Mouse   512 DKSFIQRSNLIIHQRVH-TGERPYICKECGKSFTKCSTLQIHQKIHTGEKPYKCMECNKSFTQDS 575

  Fly   577 KLKTHMQKAHAASQPH 592
            .|:|| |:.|...:|:
Mouse   576 HLRTH-QRVHTGERPY 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	9/60 (15%)
		COG5048	198..>508	CDD:227381	96/343 (28%)
		C2H2 Zn finger	221..241	CDD:275368	8/19 (42%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	4/21 (19%)
		C2H2 Zn finger	338..359	CDD:275368	10/22 (45%)
		C2H2 Zn finger	367..384	CDD:275368	6/16 (38%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Zfp53	NP_038871.1	KRAB	53..93	CDD:396083	5/39 (13%)
		COG5048	223..627	CDD:227381	121/402 (30%)
		C2H2 Zn finger	228..248	CDD:275368	8/19 (42%)
		C2H2 Zn finger	256..276	CDD:275368	8/19 (42%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		C2H2 Zn finger	312..332	CDD:275368	4/21 (19%)
		C2H2 Zn finger	340..360	CDD:275368	9/20 (45%)
		C2H2 Zn finger	370..388	CDD:275368	6/17 (35%)
		C2H2 Zn finger	396..416	CDD:275368	3/19 (16%)
		C2H2 Zn finger	424..444	CDD:275368	5/19 (26%)
		C2H2 Zn finger	452..472	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	536..556	CDD:275368	6/19 (32%)
		C2H2 Zn finger	564..584	CDD:275368	7/20 (35%)
		C2H2 Zn finger	592..612	CDD:275368
		C2H2 Zn finger	620..640	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100