DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp994

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001192024.1	Gene:	Zfp994 / 240038	MGIID:	3643318	Length:	661	Species:	Mus musculus

Alignment Length:	617	Identity:	156/617 - (25%)
Similarity:	236/617 - (38%)	Gaps:	143/617 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CDFENGSNNSHFLDLHHPNCWPSEMAQIRLQFANWNLKISPNDGL-------------------- 58
            |.:||           |.||:            |....||.|.|:
Mouse   128 CKYEN-----------HVNCF------------NLCSTISLNQGINIGKKEYNGAKLDKVFDSKE 169

  Fly    59 ------------PQKI--CSDCFTKFCSINAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQEDL 109
                        |.|.  |:.||.|.|   .||      :.:.:|..:|....:..|....|:.
Mouse   170 ILMLKQTKSVKKPYKCSECAKCFAKKC---WFR------KHQTTHTGEKFYKCNECDKSFTQKG- 224

  Fly   110 EPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPI 174
             ....||:..|.|         :|.. .|:..:.|:...|:           ::.|.....|:|
Mouse   225 -SLSIHQKYHTGK---------KPYK-CSECEKCFIQVGDL-----------RRHQRIHTGEKP- 266

  Fly   175 TDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLK 239
                        |.|..|   ::.:..:..|..| ...|..|:||.|.||:..|....|.::||:
Mouse   267 ------------YKCNEC---EKCFSYKSSLRTH-QRIHTGEKPYKCSECDKCFSHKGSLSIHLR 315

  Fly   240 SSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFK 304
            ....||.:.|..|.|.:..:.:|..|...:..|..:.|:.|:|.|..:.||..|...|..::.:|
Mouse   316 IHTGEKPYKCSECDKSFTQKGSLSIHQRIHAGEKPYRCSECDKGFTLKCSLIIHQIIHTGEKAYK 380

  Fly   305 CRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCAN 369
            |  |.|::.|..:..|..|:..|:|   .|...|..|.|.|.....||.| ...|.|||||||:.
Mouse   381 C--SECDKCFSLKSDLSIHQRIHTG---EKLYRCSECDKCFTKKYRLRSH-QTIHTGEKPYKCSE 439

  Fly   370 CTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNK 434
            |.:.|......|||. ..|    |..:..:|..|.:.|:.:..||.|......::|
Mouse   440 CDKSFTLKGHLRIHQ-RIH----TGEKPYKCNECDKCFTQKCSLIIHHRIHAGEKP--------- 490

  Fly   435 RVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKT 499
                          ::|..|.:.:..||.|..|..:|. .::|:.|..|:|.|.....::.|.:.
Mouse   491 --------------YKCSECDKYYTRKSHLIVHQRIHI-GEKPYKCSECNKCFTNKYCLRTHQRI 540

  Fly   500 HEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYK 564
            |...||..|..|.|:|||...|..||:.| ..||.:||:.||:.:..:.||.:|||.|||:..||
Mouse   541 HSANKPYKCSECDKSFALNARLRCHRIIH-TGEKPYKCSKCGKYFTQKGSLIIHQRIHTGEKPYK 604

  Fly   565 CDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            |..|.:.|.....|..| |:.|...:|:...:
Mouse   605 CSECDKYFTRKSSLNVH-QRVHTGEKPYKCSE 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	20/106 (19%)
		COG5048	198..>508	CDD:227381	84/309 (27%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp994	NP_001192024.1	KRAB	13..52	CDD:396083
		C2H2 Zn finger	185..205	CDD:275368	7/28 (25%)
		C2H2 Zn finger	213..233	CDD:275368	4/21 (19%)
		C2H2 Zn finger	241..261	CDD:275368	4/30 (13%)
		COG5048	265..661	CDD:227381	122/425 (29%)
		C2H2 Zn finger	269..289	CDD:275368	4/23 (17%)
		C2H2 Zn finger	297..317	CDD:275368	7/19 (37%)
		C2H2 Zn finger	325..345	CDD:275368	5/19 (26%)
		C2H2 Zn finger	353..373	CDD:275368	7/19 (37%)
		C2H2 Zn finger	381..401	CDD:275368	6/21 (29%)
		C2H2 Zn finger	409..429	CDD:275368	7/20 (35%)
		C2H2 Zn finger	437..457	CDD:275368	6/20 (30%)
		C2H2 Zn finger	465..485	CDD:275368	6/19 (32%)
		C2H2 Zn finger	493..513	CDD:275368	6/19 (32%)
		C2H2 Zn finger	521..541	CDD:275368	5/19 (26%)
		C2H2 Zn finger	549..569	CDD:275368	9/19 (47%)
		C2H2 Zn finger	577..597	CDD:275368	8/19 (42%)
		C2H2 Zn finger	605..625	CDD:275368	6/20 (30%)
		C2H2 Zn finger	633..653	CDD:275368	0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100