DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp867

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_848504.2	Gene:	Zfp867 / 237775	MGIID:	2681848	Length:	473	Species:	Mus musculus

Alignment Length:	475	Identity:	121/475 - (25%)
Similarity:	200/475 - (42%)	Gaps:	69/475 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 EIFVDAVDIDEAEEEE--EEEEQQQQ--------------YDEEVEEPITDESAPPQLTISYACK 190
            |:|.:...|::..|::  |:|::..|              |:.|      :.|..|.....|...
Mouse    43 EVFRNLTSIEKGWEDQNVEDEDKNPQTNLRHIIANSGYNLYESE------ESSEKPYKCTQYRSS 101

  Fly   191 FCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKK 255
            |         :..:.::....:....:||.|..|...|...:...:||::...||.:.|..|||.
Mouse   102 F---------ISLMSIQRHMITDTGSKPYKCMLCGKAFHFPSEFRIHLRTHTGEKPYECKECGKA 157

  Fly   256 YGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHL 320
            :....:.|.|...:..|..:.|..|.|.|....|:..|.:.|..::.:.|:.  |.:.|....:|
Mouse   158 FSHSSSFRKHERTHTGERPYVCKQCGKAFNCSGSIRKHERTHTGEKPYSCKQ--CGKAFNCPSYL 220

  Fly   321 MCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHML 385
            ..||.:|:|   .|...|..|||||....:||.| .|.|.|||||:|..|.:.|:..:..|
Mouse   221 QIHERSHTG---EKPYECKQCGKTFSCSSSLRKH-ERTHTGEKPYECKQCGKAFSCSSSFR---- 277

  Fly   386 ERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQ 450
             :|....|..:..||..|.:.|.|...:..||    ::..|                   :|.|:
Mouse   278 -KHERTHTGEKPYECKQCGKAFFSLTSVRTHM----IKHTG-------------------NGPFK 318

  Fly   451 CGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAF 515
            |..|.:.|...|...||.:.|:.:.:|:.|..|:|.|.....::.|.::|..|:|.....|||||
Mouse   319 CNVCEEVFPFSSVFRRHQSSHAGEKQPYGCKQCNKWFSSNTSLQNHRRSHTGEEPYAYKQCGKAF 383

  Fly   516 ALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKT 580
            :....:.:|..:|.. ||.:.|..||:.:....||:.|:|.|.|:..||.:.....|.....|:.
Mouse   384 SCPSYIRKHERAHSG-EKPYPCKQCGKCFSASSSLQTHERIHAGEKPYKREQGARAFSCSTSLRR 447

  Fly   581 HMQKAHAA--SQPHSADQPL 598
            | ::||:.  :..:|..:||
Mouse   448 H-EQAHSGENAYEYSVGKPL 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	80/309 (26%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	2/16 (13%)
Zfp867	NP_848504.2	KRAB	12..>52	CDD:214630	2/8 (25%)
		KRAB	12..51	CDD:279668	2/7 (29%)
		C2H2 Zn finger	95..115	CDD:275368	2/28 (7%)
		COG5048	119..>431	CDD:227381	98/346 (28%)
		C2H2 Zn finger	123..143	CDD:275368	5/19 (26%)
		zf-H2C2_2	135..160	CDD:290200	8/24 (33%)
		C2H2 Zn finger	151..171	CDD:275368	6/19 (32%)
		zf-H2C2_2	163..188	CDD:290200	7/24 (29%)
		C2H2 Zn finger	179..199	CDD:275368	6/19 (32%)
		zf-H2C2_2	191..216	CDD:290200	6/26 (23%)
		C2H2 Zn finger	207..227	CDD:275368	6/21 (29%)
		zf-H2C2_2	219..244	CDD:290200	12/27 (44%)
		C2H2 Zn finger	235..255	CDD:275368	10/20 (50%)
		zf-H2C2_2	247..272	CDD:290200	13/25 (52%)
		C2H2 Zn finger	263..283	CDD:275368	5/24 (21%)
		zf-H2C2_2	275..298	CDD:290200	6/27 (22%)
		C2H2 Zn finger	291..311	CDD:275368	6/23 (26%)
		C2H2 Zn finger	319..339	CDD:275368	6/19 (32%)
		C2H2 Zn finger	348..368	CDD:275368	5/19 (26%)
		C2H2 Zn finger	376..396	CDD:275368	6/19 (32%)
		zf-H2C2_2	390..412	CDD:290200	7/22 (32%)
		C2H2 Zn finger	404..424	CDD:275368	7/19 (37%)
		C2H2 Zn finger	432..452	CDD:275368	3/20 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100