DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp454

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001369380.1	Gene:	Zfp454 / 237758	MGIID:	2679253	Length:	536	Species:	Mus musculus

Alignment Length:	529	Identity:	147/529 - (27%)
Similarity:	213/529 - (40%)	Gaps:	127/529 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 SDPIEIFVDAVDIDEAEEEEEEEE-QQQQYDE---------EVEEPITDESAPPQLTISYACKF- 191
            |.| ::|....:::|...||..|. .....||         |.:.|:|.|     :|::.:.||
Mouse    59 SQP-DMFFPLEEVEECVSEEAPEGFVLDAADEPHLGPRSACEAQVPVTGE-----ITVAMSKKFL 117

  Fly   192 --------------------------CLRPQENYQLQQLLLEHINA------------SHDPEQ- 217
                                      |...|| .:|||::|...|.            |..|.|
Mouse   118 KADIPEKESDQWIAKERACANLFNWQCQEGQE-VKLQQVVLTQQNTPSKLSEQRVRAESSSPIQS 181

  Fly   218 --------PYNCPECEARFQDAASRTVH-----------LKSSHVEKQHACGVCGKKYGDRHNLR 263
                    .:.|.||...|..:::...|           .||...||::.|..|||.:....:|.
Mouse   182 QRSQASKTAFECSECGKAFSKSSTLKKHQKLHTEKLNPSQKSPMKEKRYKCRECGKAFHQSTHLI 246

  Fly   264 HHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHS 328
            ||...:..|..::|..|.|.|....||:||.|.|..::.|:|  :.|.:.||...||..|...|:
Mouse   247 HHQRVHTGEKPYQCKDCGKAFSVSSSLSYHQKIHTGEKPFEC--NVCGKAFIRNIHLSHHHRMHT 309

  Fly   329 GTSSRKSEHCGFCGKTFI---HLKTLRWHIYRQHGGEKPYKCANCTEVF---ASYAE-KRIHMLE 386
            |   .|...|..|.|.|:   || |...||   |.|:|||||..|.:.|   .|:.: :|||
Mouse   310 G---EKPFQCNLCDKAFVCRAHL-TKHQHI---HSGKKPYKCNECGKAFNQSTSFLQHQRIH--- 364

  Fly   387 RHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQC 451
                  |..:..||..|.:.|.....|..|......::|                       :||
Mouse   365 ------TGEKPFECNECGKAFRVNSSLTEHQRIHTGEKP-----------------------YQC 400

  Fly   452 GSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFA 516
            ..|.:.|...|:..||..:|: .::|:.|..|.|.|:....:..|.:||..|||..|::|.|||:
Mouse   401 IECGKAFRDNSSFARHRKIHT-GEKPYRCGLCEKAFRDQSALAQHQRTHTGEKPYTCNICEKAFS 464

  Fly   517 LKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTH 581
            ....||||:..| ..||.:||..||:|::....|..|||.|||:..|||:.|.:.|.....|..|
Mouse   465 DHSALTQHKRIH-TREKPYKCKTCGKAFIRSTHLIQHQRIHTGEKPYKCNTCGKAFNQTANLAQH 528

  Fly   582 MQKAHAASQ 590
             |:.|...:
Mouse   529 -QRHHTGGK 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	95/348 (27%)
		C2H2 Zn finger	221..241	CDD:275368	6/30 (20%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	9/19 (47%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	9/23 (39%)
		C2H2 Zn finger	367..384	CDD:275368	6/20 (30%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp454	NP_001369380.1	KRAB	14..67	CDD:214630	3/8 (38%)
		C2H2 Zn finger	193..213	CDD:275368	5/19 (26%)
		COG5048	197..532	CDD:227381	116/378 (31%)
		C2H2 Zn finger	232..252	CDD:275368	7/19 (37%)
		C2H2 Zn finger	260..280	CDD:275368	9/19 (47%)
		C2H2 Zn finger	288..308	CDD:275368	7/21 (33%)
		C2H2 Zn finger	316..336	CDD:275368	9/23 (39%)
		C2H2 Zn finger	344..364	CDD:275368	5/19 (26%)
		C2H2 Zn finger	372..392	CDD:275368	5/19 (26%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	428..448	CDD:275368	5/19 (26%)
		C2H2 Zn finger	456..476	CDD:275368	9/19 (47%)
		C2H2 Zn finger	484..504	CDD:275368	8/19 (42%)
		C2H2 Zn finger	512..532	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100