DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZKSCAN5

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001305011.1	Gene:	ZKSCAN5 / 23660	HGNCID:	12867	Length:	839	Species:	Homo sapiens

Alignment Length:	714	Identity:	153/714 - (21%)
Similarity:	268/714 - (37%)	Gaps:	195/714 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 HHPNCWPSEMA-----QIRLQFANWNLKISPNDGLPQKICS-DCFTKFCSINAFRL------ACQ 81
            |||......:|     |..|:.....:...| |.||:|:.: ....:.||.:...:      |.|
Human   113 HHPESGEEAVAVIENIQRELEERRQQIVACP-DVLPRKMATPGAVQESCSPHPLTVDTQPEQAPQ 176

  Fly    82 EAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFV- 145
            :.:|...:....:...||           |.::.||. |....:|.|.:.......:|....|:
Human   177 KPRLLEENALPVLQVPSL-----------PLKDSQEL-TASLLSTGSQKLVKIEEVADVAVSFIL 229

  Fly   146 -DAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHI 209
             :...:|::::....:::::.|..     ||        ::.|         |:....:|:::.|
Human   230 EEWGHLDQSQKSLYRDDRKENYGS-----IT--------SMGY---------ESRDNMELIVKQI 272

  Fly   210 NASHDPEQPYNCPE--------------------------------------CEARFQDAASRTV 236
              |.|.|..:..||                                      .:.|..||.:...
Human   273 --SDDSESHWVAPEHTERSVPQDPDFAEVSDLKGMVQRWQVNPTVGKSRQNPSQKRDLDAITDIS 335

  Fly   237 HLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDR 301
            ..:|:|.|:.|.|..|||.:....|...|...:..|..|:|..|.|.:..|..|..|.:.|..::
Human   336 PKQSTHGERGHRCSDCGKFFLQASNFIQHRRIHTGEKPFKCGECGKSYNQRVHLTQHQRVHTGEK 400

  Fly   302 QFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYK 366
            .:||:  .|.:.|....||:.|.:.|||   .:...|..|||.|.....|..|: ::|..||..:
Human   401 PYKCQ--VCGKAFRVSSHLVQHHSVHSG---ERPYGCNECGKNFGRHSHLIEHL-KRHFREKSQR 459

  Fly   367 CAN-----------------------------------------C--------------TEVFAS 376
            |::                                         |              .|:...
Human   460 CSDKRSKNTKLSVKKKISEYSEADMELSGKTQRNVSQVQDFGEGCEFQGKLDRKQGIPMKEILGQ 524

  Fly   377 YAEKRIHMLE---RHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRP------GAPIIAN 432
            .:.||::..|   .|:::.|.....:|..|.:.|.....||.|......::|      |.   :.
Human   525 PSSKRMNYSEVPYVHKKSSTGERPHKCNECGKSFIQSAHLIQHQRIHTGEKPFRCEECGK---SY 586

  Fly   433 NKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKW 495
            |:||...:.:|.::|  .:.|..|.:.|.::|.|.:|.:||| .:||..|..|.|.|.|...:..
Human   587 NQRVHLTQHQRVHTGEKPYTCPLCGKAFRVRSHLVQHQSVHS-GERPFKCNECGKGFGRRSHLAG 650

  Fly   496 HIKTHEKEKPNVCDVCGKAFALKYV-LTQHRLSH---------------------------EVLE 532
            |::.|.:||.:.|..||:.| .:|| |.:|::.|                           |:.|
Human   651 HLRLHSREKSHQCRECGEIF-FQYVSLIEHQVLHMGQKNEKNGICEEAYSWNLTVIEDKKIELQE 714

  Fly   533 KNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            :.::|::||:|:.:...|..|.||||.:..|:||:|:|........|.| ||.:::::.|...:
Human   715 QPYQCDICGKAFGYSSDLIQHYRTHTAEKPYQCDICRENVGQCSHTKQH-QKIYSSTKSHQCHE 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	16/69 (23%)
		COG5048	198..>508	CDD:227381	90/413 (22%)
		C2H2 Zn finger	221..241	CDD:275368	5/57 (9%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	5/71 (7%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/20 (40%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZKSCAN5	NP_001305011.1	SCAN	46..155	CDD:128708	11/42 (26%)
		SCAN	47..134	CDD:280241	6/20 (30%)
		KRAB	222..257	CDD:279668	6/47 (13%)
		COG5048	318..762	CDD:227381	109/454 (24%)
		C2H2 Zn finger	348..368	CDD:275368	6/19 (32%)
		zf-H2C2_2	360..385	CDD:290200	7/24 (29%)
		C2H2 Zn finger	376..396	CDD:275368	6/19 (32%)
		zf-H2C2_2	388..411	CDD:290200	6/24 (25%)
		C2H2 Zn finger	404..424	CDD:275368	6/21 (29%)
		C2H2 Zn finger	432..452	CDD:275368	7/20 (35%)
		zf-C2H2	549..571	CDD:278523	6/21 (29%)
		C2H2 Zn finger	551..571	CDD:275368	6/19 (32%)
		zf-H2C2_2	563..588	CDD:290200	5/27 (19%)
		C2H2 Zn finger	579..599	CDD:275368	5/22 (23%)
		zf-H2C2_2	591..614	CDD:290200	4/22 (18%)
		C2H2 Zn finger	607..627	CDD:275368	6/19 (32%)
		zf-H2C2_2	619..644	CDD:290200	11/25 (44%)
		C2H2 Zn finger	635..655	CDD:275368	6/19 (32%)
		C2H2 Zn finger	663..683	CDD:275368	8/20 (40%)
		zf-C2H2	717..739	CDD:278523	7/21 (33%)
		C2H2 Zn finger	719..739	CDD:275368	7/19 (37%)
		C2H2 Zn finger	747..795	CDD:275368	9/32 (28%)
		COG5048	758..>823	CDD:227381	5/21 (24%)
		zf-C2H2	773..795	CDD:278523	1/5 (20%)
		zf-H2C2_2	787..811	CDD:290200
		C2H2 Zn finger	803..823	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100