DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp612

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_006530970.1	Gene:	Zfp612 / 234725	MGIID:	2443465	Length:	735	Species:	Mus musculus

Alignment Length:	426	Identity:	122/426 - (28%)
Similarity:	186/426 - (43%)	Gaps:	65/426 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 YACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGV 251
            |.||.|   .:.:.:...|:.| ...|..|:||.|.:|.|.|..:::...|.::...||.:.|..
Mouse   344 YQCKVC---GKAFSVNGSLVRH-QRIHTGEKPYQCKDCGAGFGCSSAYITHQRTHTGEKPYECSD 404

  Fly   252 CGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCR---------- 306
            |||.:.....|..|...:..|..:||.:|.|.|.....|..|...|..::..:|.
Mouse   405 CGKAFNVNAKLIQHQRIHTGEKPYECDVCGKGFRCSTQLRQHQSIHTGEKPHRCSECGKGFTKNA 469

  Fly   307 --------HSG--------CERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHI 355
                    |:|        |.:.|.::..|:.|:..|:|   .:...|..|||:|.....||.|:
Mouse   470 KLIQHQRVHTGEKPYACSDCGKTFSAKGKLIQHQRIHTG---ERPYECSECGKSFRCNSQLRQHL 531

  Fly   356 YRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAE 420
             |.|.|||||||:.|.:.|...|:     |.:||...|..:..||..|.:.|:|:.:|:.|..|.
Mouse   532 -RIHTGEKPYKCSECGKAFNVNAK-----LMQHRRTHTGEKPFECKECGKCFTSKRNLLDHQRAH 590

  Fly   421 HLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSK 485
            ..::|                       :||..|.:.|::.:.|.||..:|: :::|..|..|.|
Mouse   591 TGEKP-----------------------YQCSECGKAFSINAKLTRHQQIHT-REKPFKCMECEK 631

  Fly   486 RFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSL 550
            .|..:.|...|.:.|..|||..|..|||||.:...|.:|:.|| ..||.|:|..||:.:......
Mouse   632 AFSCSSDYIVHQRIHTGEKPFQCGECGKAFHVNAHLIRHQRSH-TGEKPFRCTECGKGFSLSSDC 695

  Fly   551 RLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAH 586
            .:||..||.|..|.|::|.:.|....:|..| |..|
Mouse   696 IIHQTVHTWKKPYVCNVCGKTFRFSFQLSQH-QDVH 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	89/335 (27%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/47 (15%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp612	XP_006530970.1	KRAB	74..134	CDD:214630
		C2H2 Zn finger	290..310	CDD:275368
		COG5048	314..720	CDD:227381	118/413 (29%)
		C2H2 Zn finger	318..338	CDD:275368
		C2H2 Zn finger	346..366	CDD:275368	5/23 (22%)
		C2H2 Zn finger	374..394	CDD:275368	5/19 (26%)
		C2H2 Zn finger	402..422	CDD:275368	6/19 (32%)
		C2H2 Zn finger	430..450	CDD:275368	6/19 (32%)
		C2H2 Zn finger	458..478	CDD:275368	1/19 (5%)
		C2H2 Zn finger	486..506	CDD:275368	4/19 (21%)
		C2H2 Zn finger	514..534	CDD:275368	9/20 (45%)
		C2H2 Zn finger	542..562	CDD:275368	7/24 (29%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..618	CDD:275368	6/19 (32%)
		C2H2 Zn finger	626..646	CDD:275368	6/19 (32%)
		C2H2 Zn finger	654..674	CDD:275368	8/19 (42%)
		C2H2 Zn finger	682..702	CDD:275368	5/19 (26%)
		C2H2 Zn finger	710..730	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100