DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp764

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_666315.3	Gene:	Zfp764 / 233893	MGIID:	2443580	Length:	431	Species:	Mus musculus

Alignment Length:	422	Identity:	105/422 - (24%)
Similarity:	159/422 - (37%)	Gaps:	113/422 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 PEQPYNC--PECEARFQDAASRTVHLKSS-------------HVEKQHACGVCGKKYGDRHNLRH 264
            ||: :.|  |...|.:::....|..|.:|             ..|:....|.|.:
Mouse    33 PEE-WRCLRPAQRALYREVMRETYGLLASLGLGGAKPALICWVEEESEVWGPCAQ---------- 86

  Fly   265 HVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRH-----------SGCERLFISQR 318
                     |.|.|:|....::                 .|||           ...::.|..:.
Mouse    87 ---------DPEVAMCRTEVHS-----------------DCRHEKERKRPREETEAMQKTFSPEP 125

  Fly   319 HLMCHEATHSGTSS---------RKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVF 374
            .....:.:.:|::|         .|...|..|||:|....||..|:| .|.||||::|.:|.:.|
Mouse   126 GQKEPQLSFAGSASGIQATVLRADKRHGCHLCGKSFAQRPTLVEHLY-THTGEKPFQCPDCNKCF 189

  Fly   375 ASYAEKRIHMLERHRENLTAIERSE----CMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKR 435
            .     |...|..||    ||.|.|    |..|.:.|:....|:.||.....::|
Mouse   190 G-----RASSLTMHR----AIHRGERPHQCPDCGKSFTQRSTLVAHMYTHTGEKP---------- 235

  Fly   436 VLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTH 500
                         |.|..|::.|:..|:|..|.|:| ..:|||.||.|.:.|.|...:..|::.|
Mouse   236 -------------FCCPDCNKSFSRSSSLSSHRAIH-RGERPHCCPDCGRAFTRRSGLIAHLRIH 286

  Fly   501 EKEKPNVCDVCGKAFALKYVLTQH-RLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYK 564
            ..|||..|..||:.|:.:....:| |:.|..:.. |.|..||||:...|.||.|.|.|||:..|.
Mouse   287 TGEKPYCCADCGRCFSQRSAFREHQRVVHSGVTP-FTCTHCGRAFADSKYLRRHMRIHTGEKPYS 350

  Fly   565 CDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            |..|...|....::..| ::.|...:|:...|
Mouse   351 CPDCGRCFRQSSEIPAH-RRTHTGERPYPCPQ 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	76/331 (23%)
		C2H2 Zn finger	221..241	CDD:275368	5/21 (24%)
		C2H2 Zn finger	249..269	CDD:275368	2/19 (11%)
		C2H2 Zn finger	277..297	CDD:275368	2/19 (11%)
		C2H2 Zn finger	305..327	CDD:275368	4/32 (13%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	6/20 (30%)
		C2H2 Zn finger	537..557	CDD:275368	10/19 (53%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
Zfp764	NP_666315.3	KRAB	22..81	CDD:214630	9/48 (19%)
		KRAB	22..55	CDD:279668	5/22 (23%)
		C2H2 Zn finger	154..174	CDD:275368	9/20 (45%)
		zf-H2C2_2	167..191	CDD:290200	11/29 (38%)
		COG5048	178..>243	CDD:227381	23/96 (24%)
		C2H2 Zn finger	182..202	CDD:275368	8/28 (29%)
		zf-H2C2_2	194..219	CDD:290200	10/28 (36%)
		C2H2 Zn finger	210..230	CDD:275368	6/19 (32%)
		zf-H2C2_2	223..243	CDD:290200	7/42 (17%)
		COG5048	262..>317	CDD:227381	20/54 (37%)
		C2H2 Zn finger	266..286	CDD:275368	6/19 (32%)
		zf-H2C2_2	282..303	CDD:290200	9/20 (45%)
		zf-C2H2	321..343	CDD:278523	11/21 (52%)
		C2H2 Zn finger	323..343	CDD:275368	10/19 (53%)
		zf-H2C2_2	335..360	CDD:290200	11/24 (46%)
		C2H2 Zn finger	351..371	CDD:275368	4/20 (20%)
		zf-H2C2_2	367..388	CDD:290200	4/16 (25%)
		C2H2 Zn finger	379..399	CDD:275368	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100