DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp420

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001351547.1	Gene:	Zfp420 / 233058	MGIID:	2444666	Length:	578	Species:	Mus musculus

Alignment Length:	467	Identity:	136/467 - (29%)
Similarity:	195/467 - (41%)	Gaps:	71/467 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 YACKFCLRPQENYQLQQLLLEH------------------INAS--------HDPEQPYNCPECE 225
            |.||.|  .:...|..||:|.|                  |.:|        |..|:|:.|.||.
Mouse    85 YTCKEC--GKAFTQSSQLILHHRIHTGEKPYKCEACGKAFIRSSQLSRHQKVHTGEKPFECKECG 147

  Fly   226 ARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSL 290
            ..|...:..|:|.:....||.:.|..|.|.:.....|..|...:..|..:||..|.|.|.....|
Mouse   148 KAFTQNSQLTLHQRLHTGEKLYDCKECRKVFTQLSQLILHRRIHTGEKPYECNECGKAFICGSQL 212

  Fly   291 NYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCG---------------- 339
            :.|.|.||.::.::|:.  |.:.||....||.|:..|:|....|.:.||
Mouse   213 SQHRKIHNGEKPYECKE--CGKAFIRGSLLMQHQRIHTGEKPYKCDECGKAFIRGSQLTQHQRVH 275

  Fly   340 ---------FCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAI 395
                     .|||||.|...|..| .|.|.|||||:|..|.:.|     .|..:|.||:...|..
Mouse   276 TNEKPYECKECGKTFSHGSQLTQH-QRIHTGEKPYQCKECGKAF-----NRGSLLTRHQRIHTGE 334

  Fly   396 ERSECMLCRQPFSSEPDLIHHMSAEHLQRP------GAPIIANNKRVLQQKRERQYSGLFQCGSC 454
            :..:|..|.:.||...:|..|......::|      |...| ...::.|.:|.......::|..|
Mouse   335 KPYKCKECGKNFSRGSELTQHERIHTGEKPYECKECGKSFI-RGSQLTQHQRIHTGEKPYECKEC 398

  Fly   455 SQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKY 519
            ...|...|.|.:|..:|: .::|:.|..|.|.|.|...:..|.:.|..|||..|..|||||....
Mouse   399 RMAFTQSSHLSQHQRLHT-GEKPYVCSECGKAFARGLLLIQHQRIHTGEKPYQCRECGKAFIRSS 462

  Fly   520 VLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQK 584
            .||||:.:| ..||.::|..||:|:.....|.||||.|||:..|:|..|::.|.....|..| |:
Mouse   463 QLTQHQRTH-TGEKPYECRECGKAFGHGSQLTLHQRVHTGEKPYECKECRKAFTQSSHLSRH-QR 525

  Fly   585 AHAASQPHSADQ 596
            .|...:|:...:
Mouse   526 VHTGEKPYQCKE 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	98/366 (27%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	11/45 (24%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp420	NP_001351547.1	COG5048	23..462	CDD:227381	108/388 (28%)
		C2H2 Zn finger	31..51	CDD:275368
		C2H2 Zn finger	59..79	CDD:275368
		C2H2 Zn finger	87..107	CDD:275368	8/21 (38%)
		C2H2 Zn finger	115..135	CDD:275368	2/19 (11%)
		C2H2 Zn finger	143..163	CDD:275368	6/19 (32%)
		C2H2 Zn finger	171..191	CDD:275368	5/19 (26%)
		C2H2 Zn finger	199..219	CDD:275368	7/19 (37%)
		C2H2 Zn finger	227..247	CDD:275368	7/21 (33%)
		C2H2 Zn finger	255..275	CDD:275368	2/19 (11%)
		C2H2 Zn finger	283..303	CDD:275368	9/20 (45%)
		C2H2 Zn finger	311..331	CDD:275368	7/24 (29%)
		C2H2 Zn finger	339..359	CDD:275368	6/19 (32%)
		C2H2 Zn finger	367..387	CDD:275368	4/20 (20%)
		C2H2 Zn finger	395..415	CDD:275368	6/19 (32%)
		C2H2 Zn finger	423..443	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	10/19 (53%)
		zf-H2C2_2	464..488	CDD:372612	11/24 (46%)
		C2H2 Zn finger	479..499	CDD:275368	9/19 (47%)
		zf-H2C2_2	492..516	CDD:372612	12/23 (52%)
		C2H2 Zn finger	507..527	CDD:275368	6/20 (30%)
		zf-H2C2_2	519..544	CDD:372612	5/20 (25%)
		C2H2 Zn finger	535..555	CDD:275368	0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100