DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp940

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_776099.1	Gene:	Zfp940 / 233057	MGIID:	2446235	Length:	566	Species:	Mus musculus

Alignment Length:	575	Identity:	134/575 - (23%)
Similarity:	210/575 - (36%)	Gaps:	141/575 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LQFANWNLKI----SPNDGLPQKICSDCFTK-----FC------SINAFRL-ACQEAQLKLSHIY 91
            :.|::.|.|.    |..:.|.|:...:.|.|     ||      ..|.|:. ..||...:|:..|
Mouse    79 IDFSSQNKKFLGKPSTYEELSQREMKEYFRKRSLEDFCFGDGWDGKNQFQTHQNQEYFKQLAVAY 143

  Fly    92 DKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAE-----TQPNNTASDPIEIFVDAVDID 151
            :|:...:........:.|...|:..|.:..|..|..|..     |.|.|      ::..|....|
Mouse   144 EKVLTVNQGIVFNNHQRLNAGEKATEIQCEKALTVESDRILPQLTPPGN------KVHKDKECGD 202

  Fly   152 EAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPE 216
            .:..|.|....|:.:..:..:...:...|..|           |.....|.|        .|..|
Mouse   203 TSAPESERTHCQRAHCPQTPQQGKESGGPFGL-----------PSGILGLPQ--------GHTGE 248

  Fly   217 QPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCE 281
            :.|:|.||...|...::.|.|.:....|:.:.|..|||.:..:.:|..|.:.:..:..:.|.:|.
Mouse   249 KSYDCKECGKSFTLKSNLTRHRRIHTGERPYTCHGCGKAFTQKSHLMSHQKIHTGKKAYVCGVCG 313

  Fly   282 KRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFI 346
            |.|:...||..|...|                            .|:..:.:|:..|..|||.|.
Mouse   314 KAFHCDSSLTSHQNIH----------------------------YHAADAGKKAYECKKCGKDFD 350

  Fly   347 HLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEP 411
            ....|..| .:.|.||||:||.:|..:|..::..|.|
Mouse   351 CHSGLIDH-QKVHTGEKPFKCKHCGRLFRFHSHLRAH---------------------------- 386

  Fly   412 DLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGL--FQCGSCSQRFNMKSALERHAAVHSEK 474
                                          .|.:||:  :.|..|.:.||::|.|.||..||: .
Mouse   387 ------------------------------TRIHSGVKSYDCKECGKSFNLRSNLMRHHRVHT-G 420

  Fly   475 DRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVL----EKNF 535
            :||:.|..|.|.|.:...:..|.|.|..||..||.||||||:....||.|:..|..:    :|.:
Mouse   421 ERPYTCHGCGKAFSQKSHLTSHQKIHTGEKAYVCGVCGKAFSRGSSLTSHQNIHYYVVNAGKKVY 485

  Fly   536 KCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQ 590
            :|..||:|:....:|..||:.|.|:..:||..|::.|.....|..| |:.|...:
Mouse   486 ECKECGKAFGCHSNLSRHQKIHAGEKPFKCRDCEKAFGQRAHLTKH-QRIHTGEE 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	14/59 (24%)
		COG5048	198..>508	CDD:227381	70/311 (23%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	0/21 (0%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	0/19 (0%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp940	NP_776099.1	KRAB	6..66	CDD:214630
		COG5048	<249..437	CDD:227381	61/275 (22%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	342..357	CDD:275370	6/14 (43%)
		COG5048	<366..524	CDD:227381	58/216 (27%)
		C2H2 Zn finger	370..390	CDD:275368	6/77 (8%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		C2H2 Zn finger	454..474	CDD:275368	10/19 (53%)
		C2H2 Zn finger	487..507	CDD:275368	7/19 (37%)
		C2H2 Zn finger	515..535	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100