DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp418

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_666291.2	Gene:	Zfp418 / 232854	MGIID:	2444763	Length:	652	Species:	Mus musculus

Alignment Length:	460	Identity:	131/460 - (28%)
Similarity:	197/460 - (42%)	Gaps:	42/460 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 EAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQ--ENYQLQQLLLEHINASHD 214
            :|...|:...:..:|         ::|:.||..:....:.|...:  |:...:|.|.::..|...
Mouse   192 KAFHSEKNNSKSDKY---------NKSSSPQHRLHEYPRLCSGKEGFESNSCEQDLNKYSIAPSQ 247

  Fly   215 PEQ----PYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDF 275
            .:|    ||.|.:|...|...|:..:|.:....||.:.||.|||.:....||..|...:..|..|
Mouse   248 TDQTENRPYGCHDCGKWFGQKATLRIHQRRHTGEKPYRCGECGKSFCQSSNLSEHCRVHSGERPF 312

  Fly   276 ECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGF 340
            ||..|.|.|....||..|.:.|..:..::|  ..|.|||.....|:.|:.||   ::.|...||.
Mouse   313 ECLECGKAFGCHSSLLRHQRTHTGEWPYEC--GDCGRLFRQIVSLITHQRTH---TTEKPYECGQ 372

  Fly   341 CGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYA----EKRIHMLERHRENLTAIERSECM 401
            |.|:|.|..||..| .|.|.|||||.|..|.:.|:..|    ..:||..|:      ..:..||.
Mouse   373 CEKSFSHKATLTVH-QRVHTGEKPYHCEACGKSFSQSANLIKHSKIHTGEK------PYKCGECG 430

  Fly   402 LCRQPFSSEPDLIHHMSAEHLQRP-----GAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMK 461
            ||   |.....|:.|......:||     ..........:::..|....:..::||.|.:.:...
Mouse   431 LC---FRQRATLMKHQRTHTSERPYECRECGKFFKQYFYLIEHSRIHTTTEFYECGQCGKSYTQN 492

  Fly   462 SALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRL 526
            :.|.||..||: .:.|:.|..|.|.|:....:..|.:||..|:|..|..|||.|...|.|.:|:.
Mouse   493 ATLIRHQRVHT-GESPYKCKECGKAFEYKSRLNRHQRTHTGERPYECAKCGKFFRESYNLAEHQK 556

  Fly   527 SHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQP 591
            .| ...|.:.|:.||:.:.....|..|||.|||:..|.|..|.:.|.....|..| ::.|...:|
Mouse   557 IH-TKAKPYNCDQCGKCFSRRADLVKHQRVHTGERPYTCGECGKTFSRTTNLVQH-RRIHTGERP 619

  Fly   592 HSADQ 596
            :..||
Mouse   620 YECDQ 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	93/322 (29%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp418	NP_666291.2	KRAB	25..>66	CDD:214630
		KRAB	25..64	CDD:279668
		C2H2 Zn finger	258..278	CDD:275368	5/19 (26%)
		zf-H2C2_2	271..293	CDD:290200	8/21 (38%)
		COG5048	282..639	CDD:227381	111/361 (31%)
		C2H2 Zn finger	286..306	CDD:275368	8/19 (42%)
		zf-H2C2_2	298..321	CDD:290200	9/22 (41%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		C2H2 Zn finger	342..362	CDD:275368	7/21 (33%)
		zf-H2C2_2	354..379	CDD:290200	10/27 (37%)
		C2H2 Zn finger	370..390	CDD:275368	10/20 (50%)
		zf-H2C2_2	383..407	CDD:290200	12/24 (50%)
		C2H2 Zn finger	398..418	CDD:275368	4/19 (21%)
		C2H2 Zn finger	426..446	CDD:275368	7/22 (32%)
		zf-H2C2_2	439..463	CDD:290200	4/23 (17%)
		C2H2 Zn finger	454..474	CDD:275368	1/19 (5%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		zf-H2C2_2	495..519	CDD:290200	10/24 (42%)
		C2H2 Zn finger	510..530	CDD:275368	5/19 (26%)
		zf-H2C2_2	523..545	CDD:290200	9/21 (43%)
		C2H2 Zn finger	538..558	CDD:275368	8/19 (42%)
		C2H2 Zn finger	566..586	CDD:275368	7/19 (37%)
		zf-H2C2_2	578..603	CDD:290200	11/24 (46%)
		C2H2 Zn finger	594..614	CDD:275368	5/20 (25%)
		zf-H2C2_2	606..631	CDD:290200	6/20 (30%)
		C2H2 Zn finger	622..642	CDD:275368	2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100