DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp189

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001276830.1	Gene:	Zfp189 / 230162	MGIID:	2444707	Length:	608	Species:	Mus musculus

Alignment Length:	536	Identity:	141/536 - (26%)
Similarity:	223/536 - (41%)	Gaps:	101/536 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 EDLEPAEEHQETETTKP----TTTVSAETQPNNTASDPIEIFVDAVD------IDEAEEEEEEEE 161
            :|.||..:.:..:..:|    .|.:.:|...:...|:..|: |..:|      :.|...:...||
Mouse    46 KDEEPTVKEELEKDIEPQGVIVTRIKSEIDQDPVGSETFEL-VGRLDKQRGIFLWEIPRDSLSEE 109

  Fly   162 QQ--QQYDEEVEEPITDESAPPQLTISYACKFC----LRPQENYQLQQLLLEHINASHDPEQPYN 220
            |:  :.:....:.|.::|..       :.|:.|    :|.....|.|::        |..|:|:.
Mouse   110 QKLFRGHTNVRKRPTSEEKC-------HKCEECGKRFVRKAHFIQHQRV--------HTGEKPFQ 159

  Fly   221 CPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFY 285
            |.||...|..::....|.:....|:.:.|..|||.:.....|..|...:..|..::|..|::.|.
Mouse   160 CNECGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSSTLIRHQRIHTGERPYQCNQCKQSFS 224

  Fly   286 TRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKT 350
            .|:||..|.:.|..::..||  |.|.:.|..:.||:.|:.||:|   .|..||..|.|:|.....
Mouse   225 QRRSLVKHQRIHTGEKPHKC--SDCGKAFSWKSHLIEHQRTHTG---EKPYHCTKCKKSFSRNSL 284

  Fly   351 LRWHIYRQHGGEKPYKCANCTEVF--ASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDL 413
            |..| .|.|.||:|:||..|.:.|  ::|       |.:|::..|..:...|:.|.:.||....|
Mouse   285 LVEH-QRIHTGERPHKCGECGKAFRLSTY-------LIQHQKIHTGEKPFLCIECGKSFSRSSFL 341

  Fly   414 IHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPH 478
            |.|......:||                       :||..|.:.|:....|.||..:|: .|:||
Mouse   342 IEHQRIHTGERP-----------------------YQCQECGKSFSQLCNLTRHQRIHT-GDKPH 382

  Fly   479 ACPHCSKRFKRAQDMKWHIKTHEKEK------------PNV----------------CDVCGKAF 515
            .|..|.|.|.|:..:..|.:.|.:||            ||.                ||.|||.|
Mouse   383 KCEECGKAFSRSSGLIQHQRIHIREKTSPFSETKESFDPNCSLVIQQEVSPKEKSYKCDDCGKTF 447

  Fly   516 ALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKT 580
            ::...|.||:..| ..||.:.|.|||:::.....|..|||.|||:..|.|..|.:.|.....|..
Mouse   448 SVSAHLVQHQRIH-TGEKPYLCTVCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQLCNLIR 511

  Fly   581 HMQKAHAASQPHSADQ 596
            | |..|..::||..::
Mouse   512 H-QGVHTGNKPHKCEE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	89/339 (26%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	4/18 (22%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp189	NP_001276830.1	KRAB_A-box	<12..39	CDD:143639
		COG5048	116..506	CDD:227381	121/442 (27%)
		C2H2 Zn finger	132..152	CDD:275368	5/27 (19%)
		zf-H2C2_2	144..169	CDD:290200	9/32 (28%)
		C2H2 Zn finger	160..180	CDD:275368	5/19 (26%)
		zf-H2C2_2	175..196	CDD:290200	6/20 (30%)
		C2H2 Zn finger	188..208	CDD:275368	6/19 (32%)
		zf-H2C2_2	201..225	CDD:290200	6/23 (26%)
		C2H2 Zn finger	216..236	CDD:275368	7/19 (37%)
		zf-H2C2_2	228..252	CDD:290200	8/25 (32%)
		C2H2 Zn finger	244..264	CDD:275368	7/21 (33%)
		zf-H2C2_2	256..281	CDD:290200	12/27 (44%)
		C2H2 Zn finger	272..292	CDD:275368	7/20 (35%)
		zf-H2C2_2	285..307	CDD:290200	10/22 (45%)
		C2H2 Zn finger	300..320	CDD:275368	6/26 (23%)
		zf-H2C2_2	312..337	CDD:290200	7/31 (23%)
		C2H2 Zn finger	328..348	CDD:275368	7/19 (37%)
		zf-H2C2_2	341..365	CDD:290200	9/46 (20%)
		C2H2 Zn finger	356..376	CDD:275368	6/19 (32%)
		zf-H2C2_2	368..393	CDD:290200	11/25 (44%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		C2H2 Zn finger	440..460	CDD:275368	9/19 (47%)
		zf-H2C2_2	452..477	CDD:290200	10/25 (40%)
		C2H2 Zn finger	468..488	CDD:275368	8/19 (42%)
		zf-H2C2_2	481..505	CDD:290200	11/23 (48%)
		C2H2 Zn finger	496..516	CDD:275368	6/20 (30%)
		zf-H2C2_2	508..533	CDD:290200	6/20 (30%)
		C2H2 Zn finger	524..544	CDD:275368	0/3 (0%)
		zf-H2C2_2	537..561	CDD:290200
		C2H2 Zn finger	552..572	CDD:275368
		C2H2 Zn finger	583..603	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100