DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp334

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_006499440.1	Gene:	Zfp334 / 228876	MGIID:	2388656	Length:	690	Species:	Mus musculus

Alignment Length:	521	Identity:	137/521 - (26%)
Similarity:	206/521 - (39%)	Gaps:	118/521 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 TQPNNT--ASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCL 193
            ||..||  ||.|.|           ..|.|:|.......||..|...:|              |.
Mouse   211 TQQQNTQSASQPSE-----------HREGEQESAGAARSEEQPERKRNE--------------CA 250

  Fly   194 RPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGD 258
            ..::.:..:..|:.|:.. |..|:||.|..|...|:..||.|.|.:....|:.:.|..|||.:.|
Mouse   251 ECRKTFSKRSTLIVHLRI-HTGERPYACNYCRKTFRIKASLTRHQRIHTGERPYKCKECGKAFID 314

  Fly   259 RHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCH 323
            :..|..|...:..|..:||..|.|.|:.:.:|..|.:.|..::.:||:.  |...|..:.:|:.|
Mouse   315 KSALIVHQRIHGGEKSYECNECGKTFFRKSALAEHFRSHTGEKPYKCKE--CGNAFGKKSYLIVH 377

  Fly   324 EATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERH 388
            :.||.|   .|...|..|||||..|..|..| .|.|.|||||:|..|.:.|...:...:| |..|
Mouse   378 QRTHRG---EKPNECKECGKTFFCLSALTAH-QRIHTGEKPYECKECDKTFFCQSALNVH-LRSH 437

  Fly   389 RENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGS 453
                |..:..:|.||.:...::..|:.|.           :|...|:.            |:|..
Mouse   438 ----TGEKPYKCRLCGKYLCTKSALVAHQ-----------VIHRGKKT------------FECPE 475

  Fly   454 CSQRFNMKSALERHAAVHS-EK------------------------------------------- 474
            |.:.|.:||.|..|...|: ||
Mouse   476 CGKLFYLKSTLTIHQRTHTGEKHGLLSKWSRASAAKPNCSEQKRADAKDNVHECHDHKRPAHKSS 540

  Fly   475 ----------DRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHE 529
                      :||:.|..|.:.:.|...::.|.|||..|:|..|..|||.|..|...|:|:.:|
Mouse   541 RRFAHKRTIWERPYECEECGRTYCRKSALRHHQKTHTGERPYECKECGKTFCQKVSFTEHQRTH- 604

  Fly   530 VLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSA 594
            ..||..||..||:::..:.:..:|:|.|||:..|.|:.|.:.:.....|..| ||.|...:|:..
Mouse   605 TGEKPHKCKECGKSFRHKSAFTVHKRIHTGEKPYACNECGKSYRRLWTLTEH-QKIHTGEKPYEC 668

  Fly   595 D 595
            :
Mouse   669 N 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	92/363 (25%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
Zfp334	XP_006499440.1	KRAB	20..79	CDD:214630
		C2H2 Zn finger	249..269	CDD:275368	3/20 (15%)
		COG5048	273..689	CDD:227381	117/433 (27%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..325	CDD:275368	7/19 (37%)
		C2H2 Zn finger	333..353	CDD:275368	6/19 (32%)
		C2H2 Zn finger	361..381	CDD:275368	5/21 (24%)
		C2H2 Zn finger	389..409	CDD:275368	10/20 (50%)
		C2H2 Zn finger	417..437	CDD:275368	5/20 (25%)
		C2H2 Zn finger	445..465	CDD:275368	5/30 (17%)
		C2H2 Zn finger	473..493	CDD:275368	7/19 (37%)
		C2H2 Zn finger	556..576	CDD:275368	5/19 (26%)
		C2H2 Zn finger	584..604	CDD:275368	8/19 (42%)
		C2H2 Zn finger	612..632	CDD:275368	5/19 (26%)
		C2H2 Zn finger	640..660	CDD:275368	6/20 (30%)
		C2H2 Zn finger	668..688	CDD:275368	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100