DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZFP30

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001307595.1	Gene:	ZFP30 / 22835	HGNCID:	29555	Length:	519	Species:	Homo sapiens

Alignment Length:	514	Identity:	137/514 - (26%)
Similarity:	204/514 - (39%)	Gaps:	103/514 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 EAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEE--HQETETTKPTTTVSAETQPNNTASDPIEIF 144
            |..|....:.::|.:..||:.|      .|.|.  .|.|:||       :|..|.......:.::
Human    97 EMNLSQWKVMERIKSCGLEEQE------SPHEVCFRQVTKTT-------SEKMPTYRKLTSLPLY 148

  Fly   145 VDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHI 209
                                |.....|:|             |.|..|   .:.::::|.|..|
Human   149 --------------------QKSHNREKP-------------YECGEC---GKAFRVRQQLTFH- 176

  Fly   210 NASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETD 274
            ...|..|:||.|.||...|:..|..:.|.:....:|.:.|..|||.:....:||.|...:..|..
Human   177 QRIHTGEKPYECKECGKAFRQCAHLSRHQRIHTSDKLYECKKCGKIFTCGSDLRVHQRIHIGEKP 241

  Fly   275 FECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCG 339
            :||..|.|.|..|..||.|.:.|..::.::|:.  |.:.|....||..|:..:   .:.|...|.
Human   242 YECKECGKAFRVRGQLNLHQRIHTGEKPYECKE--CGKAFRQYAHLTRHQRLN---IAEKCYECK 301

  Fly   340 FCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIER------- 397
            .||:.|:....||.| ::.|.|||||:|..|.:.|            |.|:.||..:|
Human   302 ECGQAFLCSTGLRLH-HKLHTGEKPYECKECGKAF------------RVRQQLTLHQRIHTGEKP 353

  Fly   398 SECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKS 462
            .:|..|.:.||....|..|......::|                       ::|..|.:.|...|
Human   354 YDCKECGKTFSRGYHLTLHQRIHTGEKP-----------------------YECKECQKFFRRYS 395

  Fly   463 ALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLS 527
            .|..|..:|. .::|:.|..|.|.|:....:..|...|..|||..|..|.|.|.|...||||:..
Human   396 ELISHQGIHI-GEKPYECKECGKAFRLFSQLTQHQSIHFGEKPFKCKECEKTFRLLSQLTQHQSI 459

  Fly   528 HEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAH 586
            | ..||.:.|..||:|:....||..|||.|:|:..|||..|::.|..|..| |:.|:.|
Human   460 H-TGEKPYDCKECGKAFRLHSSLIQHQRIHSGEKPYKCKECKKAFRQHSHL-TYHQRIH 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	2/4 (50%)
		COG5048	198..>508	CDD:227381	84/316 (27%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	6/16 (38%)
ZFP30	NP_001307595.1	KRAB	6..67	CDD:214630
		COG5048	156..509	CDD:227381	117/412 (28%)
		C2H2 Zn finger	160..180	CDD:275368	5/23 (22%)
		C2H2 Zn finger	188..208	CDD:275368	6/19 (32%)
		C2H2 Zn finger	216..236	CDD:275368	7/19 (37%)
		C2H2 Zn finger	244..264	CDD:275368	8/19 (42%)
		C2H2 Zn finger	272..291	CDD:275368	6/20 (30%)
		C2H2 Zn finger	300..320	CDD:275368	7/20 (35%)
		C2H2 Zn finger	328..348	CDD:275368	8/31 (26%)
		C2H2 Zn finger	356..376	CDD:275368	6/19 (32%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		C2H2 Zn finger	412..432	CDD:275368	5/19 (26%)
		C2H2 Zn finger	440..460	CDD:275368	9/19 (47%)
		C2H2 Zn finger	468..488	CDD:275368	9/19 (47%)
		C2H2 Zn finger	496..516	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100