DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zim1

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_035899.4	Gene:	Zim1 / 22776	MGIID:	1341879	Length:	579	Species:	Mus musculus

Alignment Length:	482	Identity:	125/482 - (25%)
Similarity:	188/482 - (39%)	Gaps:	93/482 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 ASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEE 160
            :.||..::..:.|..|::..::..:|. ||..|..:.|.|                   :|.|..
Mouse   169 SQSLRAEKTSKSDDRPSQNKEKCASTS-TTEASKTSIPGN-------------------KENESA 213

  Fly   161 EQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQL----QQLLLEHINASHDP----EQ 217
            .......:......|.:|||.:           :|.....:    |.:.....|....|    :.
Mouse   214 IPGTSSGQTSAATTTPQSAPSE-----------KPTSGKDVEGKPQTMRSSSTNPKRKPARQGKN 267

  Fly   218 PYNCPECEARFQDAASRTVHL---KSSHV-EKQHACGVCGKKYGDRHNLRHHVEKYHSET---DF 275
            .:.|.||...|    ::|:||   :..|. ||.|.|..|||.:  || |.:.:..|...|   .:
Mouse   268 HFKCKECGKTF----NQTLHLVEHERIHTGEKPHKCDTCGKSF--RH-LSYFLTHYRIHTGVRPY 325

  Fly   276 ECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGF 340
            :|..|.|.|.:..:||.|.:.|:.::.|||  ..|.:.|.....|..|:..|:|   .|...||.
Mouse   326 KCKECGKAFNSSSTLNNHCRIHSGEKPFKC--DECGKTFKQSTKLTRHQRIHTG---EKPYKCGE 385

  Fly   341 CGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRI--HMLERHRENLTAIERSECMLC 403
            |.|.|....:||.| .|.|.|||||.|..|.:.|      |:  |:.|..|.:| .::..:|..|
Mouse   386 CNKCFGRSSSLREH-KRIHTGEKPYCCQVCGKTF------RVNSHLSEHQRLHL-KVKPYKCDKC 442

  Fly   404 RQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHA 468
            .:.|.:...|..|   :.:..|||.:                    .|..|.:.|..|.||.:|.
Mouse   443 GKHFRNSSYLTEH---KQIHVPGARV--------------------DCPECGKVFACKVALLKHQ 484

  Fly   469 AVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEK 533
            ..|....| :.|..|.|.|:....::.|.:.|..|||.||..|.|.|..|..|..|...|.. ::
Mouse   485 KRHEANSR-YRCKGCGKTFRCKSSIQRHERLHAGEKPFVCHKCDKGFTDKTTLNNHLKIHSG-DR 547

  Fly   534 NFKCNVCGRAYLFEKSLRLHQRTHTGK 560
            ...|..|||.:....:|.:||:.|..|
Mouse   548 PDPCAQCGRTFKKLATLLIHQKKHIKK 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	90/326 (28%)
		C2H2 Zn finger	221..241	CDD:275368	7/22 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/18 (22%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368
Zim1	NP_035899.4	KRAB	50..105	CDD:214630
		PRK13335	137..>269	CDD:139494	20/130 (15%)
		COG5048	<226..427	CDD:227381	66/230 (29%)
		C2H2 Zn finger	271..291	CDD:275368	7/23 (30%)
		C2H2 Zn finger	299..319	CDD:275368	8/22 (36%)
		C2H2 Zn finger	327..347	CDD:275368	7/19 (37%)
		C2H2 Zn finger	355..375	CDD:275368	5/21 (24%)
		C2H2 Zn finger	383..403	CDD:275368	9/20 (45%)
		C2H2 Zn finger	411..431	CDD:275368	7/25 (28%)
		zf-C2H2	437..459	CDD:333835	5/24 (21%)
		C2H2 Zn finger	439..459	CDD:275368	5/22 (23%)
		C2H2 Zn finger	467..487	CDD:275368	7/19 (37%)
		C2H2 Zn finger	495..515	CDD:275368	5/19 (26%)
		zf-C2H2	521..543	CDD:333835	8/21 (38%)
		C2H2 Zn finger	523..543	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100