DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zik1

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_033603.2	Gene:	Zik1 / 22775	MGIID:	108070	Length:	463	Species:	Mus musculus

Alignment Length:	446	Identity:	109/446 - (24%)
Similarity:	184/446 - (41%)	Gaps:	74/446 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 EEHQETETTKPTTTVSAETQP-NNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPIT- 175
            |:.:...:|:.:..:.:||.| .|.....:.|..|.:.:.....::...|...:.|:..:...|
Mouse    60 EDEERRVSTRASKGLRSETTPKTNLCEKCVPILQDILCLPGLPGQKHSTEASSKVDQHQDHNSTG 124

  Fly   176 --------------------------DESAPPQLTI--SYACKFCLRPQENYQLQQLLLEHINAS 212
                                      ::..|..|::  |..|....:.:::.:.::      ..|
Mouse   125 KPLEKNADRSSYLFYLSAKSFPSWDVEKDLPDILSLLKSQVCPKTKKYRKSTEGRK------ETS 183

  Fly   213 HDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFEC 277
            |:.::...|....::.|..|.   |.|:|:.:|.:.|..|||.:..:::|..|...:..|..:||
Mouse   184 HESDKSEECQSLSSQKQTLAH---HPKTSNGKKLYECSKCGKTFRGKYSLDQHQRVHTGERPWEC 245

  Fly   278 ALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCG 342
            ..|.|.|.....||.|.:.|..:|.::|  |.|.:||.....|:.|:.||:|.   :...|..||
Mouse   246 RDCGKFFSQTSHLNDHRRIHTGERPYEC--SECGKLFRQNSSLVDHQKTHTGA---RPYECSQCG 305

  Fly   343 KTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPF 407
            |:|....||..| .|.|.||:||||:.|...|:..|     :|.:||...|.::..||..|.:.|
Mouse   306 KSFSQKATLVKH-KRVHTGERPYKCSECGNSFSQSA-----ILNQHRRIHTGVKPYECRECGKSF 364

  Fly   408 SSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHS 472
            |.:..||.|......:||                       ::|..|.:.|:..|.|.:|..:|:
Mouse   365 SQKATLIKHQRVHTGERP-----------------------YKCSECGKSFSQSSILIQHRRIHT 406

  Fly   473 EKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSH 528
            .. ||:.|..|.|.|.:...:..|...|..|:|..||.||.:|:....|..|:..|
Mouse   407 GA-RPYECSQCGKSFSQKSGLIQHQVVHTGERPYECDTCGNSFSQCSSLIHHQKCH 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	86/309 (28%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368
		C2H2 Zn finger	565..582	CDD:275368
Zik1	NP_033603.2	KRAB	14..52	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	106..128		3/21 (14%)
		COG5048	<112..425	CDD:227381	88/356 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..211		8/48 (17%)
		C2H2 Zn finger	190..209	CDD:275368	5/21 (24%)
		C2H2 Zn finger	217..237	CDD:275368	6/19 (32%)
		zf-H2C2_2	229..254	CDD:290200	8/24 (33%)
		C2H2 Zn finger	245..265	CDD:275368	7/19 (37%)
		zf-H2C2_2	257..282	CDD:290200	10/26 (38%)
		C2H2 Zn finger	273..293	CDD:275368	7/21 (33%)
		zf-H2C2_2	285..310	CDD:290200	10/27 (37%)
		C2H2 Zn finger	301..321	CDD:275368	9/20 (45%)
		zf-H2C2_2	314..338	CDD:290200	12/24 (50%)
		C2H2 Zn finger	329..349	CDD:275368	7/24 (29%)
		zf-H2C2_2	342..366	CDD:290200	8/23 (35%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..394	CDD:290200	8/46 (17%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	398..422	CDD:290200	9/24 (38%)
		C2H2 Zn finger	413..433	CDD:275368	5/19 (26%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100