DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp97

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_035895.3	Gene:	Zfp97 / 22759	MGIID:	105921	Length:	546	Species:	Mus musculus

Alignment Length:	539	Identity:	140/539 - (25%)
Similarity:	224/539 - (41%)	Gaps:	115/539 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 EDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEE---- 160
            |:|.| :||.|        .:.:||..:..: .|:||...|.|    .:..|.|......:
Mouse    57 EEDNI-EEDCE--------NSGRPTRHLQRD-GPSNTGEKPFE----CIQYDGAFARNHHQLHKD 107

  Fly   161 --------EQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQ 217
                    ::|.......||.:.|.:   |...:::|      ..::::::       .::..|:
Mouse   108 TGSFMSYTDRQIHRRPHTEEKVYDGN---QCGKTFSC------HNHFEIRK-------GTYTGEK 156

  Fly   218 PYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFEC----- 277
            ||.|.:|...|...::...|.:....||.:.|..|||.:.....|..|...:..|..::|
Mouse   157 PYECNQCGKAFARNSNLLDHKRIHTGEKPYKCKQCGKDFTHHSTLHIHKRIHTREKTYKCNQCMT 221

  Fly   278 --------------ALCE-----KRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCH 323
                          .|||     |.|...|:|..|.:.|..::.::|..  |.:.|...|.|..|
Mouse   222 IAHLQCHKITHTGEKLCEYNQCWKAFAYHKTLQIHERTHTGEKLYQCNQ--CAKAFPYHRTLQIH 284

  Fly   324 EATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASY----AEKRIHM 384
            |.||:|   .|...|..|||.|..|:.|:.| ...|.|||||:|..|...|..|    ..:|||.
Mouse   285 ERTHTG---EKPYECNQCGKAFACLRNLQNH-KTTHTGEKPYECNQCGRAFRQYVYLQCHERIHT 345

  Fly   385 LERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSG-- 447
            .|:         ..||..|.:.|:      ||.:.                   |:.:|.::|
Mouse   346 REK---------PFECNQCGKAFA------HHSTL-------------------QRHKRTHTGEK 376

  Fly   448 LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCG 512
            .::|..|.:.|.....|:.|...|: .::|:.|..|.|.|...|..:.|.:||..|||..|:.||
Mouse   377 PYECNQCGKAFACPRYLQIHKRTHT-GEKPYECNQCGKAFACYQSFQIHKRTHTGEKPYECNQCG 440

  Fly   513 KAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIK 577
            ||||....|..|:.:| ..|:.::||.||:|:....:|::|:|||||:..|:|:.|.:.|.....
Mouse   441 KAFACNRYLQIHKRTH-TGERPYECNQCGKAFTCRSNLQIHKRTHTGEKPYECNQCGKAFTQFFP 504

  Fly   578 LKTHMQKAHAASQPHSADQ 596
            ||.| :..|...:|:..:|
Mouse   505 LKRH-EITHTKEKPYECNQ 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	86/339 (25%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	9/43 (21%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	6/20 (30%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Zfp97	NP_035895.3	KRAB	13..>54	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	133..152	CDD:275368	2/34 (6%)
		COG5048	156..541	CDD:227381	118/410 (29%)
		C2H2 Zn finger	160..180	CDD:275368	4/19 (21%)
		zf-H2C2_2	172..197	CDD:290200	7/24 (29%)
		C2H2 Zn finger	188..208	CDD:275368	6/19 (32%)
		C2H2 Zn finger	216..232	CDD:275368	1/15 (7%)
		C2H2 Zn finger	241..260	CDD:275368	5/18 (28%)
		C2H2 Zn finger	268..288	CDD:275368	7/21 (33%)
		zf-H2C2_2	281..305	CDD:290200	12/26 (46%)
		C2H2 Zn finger	296..316	CDD:275368	8/20 (40%)
		zf-H2C2_2	308..333	CDD:290200	11/25 (44%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	336..361	CDD:290200	8/39 (21%)
		C2H2 Zn finger	352..372	CDD:275368	7/44 (16%)
		zf-H2C2_2	365..389	CDD:290200	6/42 (14%)
		C2H2 Zn finger	380..400	CDD:275368	5/19 (26%)
		zf-H2C2_2	392..417	CDD:290200	8/25 (32%)
		C2H2 Zn finger	408..428	CDD:275368	6/19 (32%)
		zf-H2C2_2	420..445	CDD:290200	12/24 (50%)
		C2H2 Zn finger	436..456	CDD:275368	9/19 (47%)
		zf-H2C2_2	448..473	CDD:290200	9/25 (36%)
		C2H2 Zn finger	464..484	CDD:275368	8/19 (42%)
		zf-H2C2_2	476..501	CDD:290200	11/24 (46%)
		C2H2 Zn finger	492..512	CDD:275368	6/20 (30%)
		zf-H2C2_2	505..529	CDD:290200	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100