DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zkscan5

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_057892.2	Gene:	Zkscan5 / 22757	MGIID:	107533	Length:	819	Species:	Mus musculus

Alignment Length:	763	Identity:	171/763 - (22%)
Similarity:	258/763 - (33%)	Gaps:	256/763 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 HHPNCWPSEMA-----QIRLQFANWNLKISPNDGLPQKICSDCFTKFCSINAFRLAC-------- 80
            |||......:|     |..|:.....:..|| :.||||:.....|:    .:|...|
Mouse   113 HHPESGEEAVAVIESIQRELEERRQQIATSP-EVLPQKMVPPGATQ----ESFSHQCLPVEAQPE 172

  Fly    81 QEAQ----------LKLSHIYDKIDASSLEDDEI--GQEDLEPAEE------------------- 114
            :|:|          |::|.:..| |:..|.|..:  |.:.|...|:
Mouse   173 RESQNLLEENALPVLQVSSVPLK-DSQELTDSLLSDGPQKLVKTEDVADVAVSFILEEWAHLDQS 236

  Fly   115 ------HQETETTKPTTTVSAETQPNN---------TASDPIEIFVDAVDIDEAEEEEEEEEQQQ 164
                  ....|..:.||.|..|.:..|         .|:||..:         |.|..|:...|:
Mouse   237 QKSLGRDSRKEDCESTTPVDYEPKEGNLEFTVQQVSDAADPHWV---------AAERTEKNGVQR 292

  Fly   165 QYDEEVEE--------PITDESAPPQL------------------TISYAC----KFCLRPQENY 199
            ....||.:        .:...|..|:.                  ...:.|    ||.|:.....
Mouse   293 PESGEVSDLKDMVPRWQVNPTSGNPRQKRPLRSGPDVNRKQKSNGERGHRCGDCGKFFLQASNFI 357

  Fly   200 QLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYG-DRHNLR 263
            |.:::        |..|:|:.|.||...:......|.|.:....||.:.|.||||.:. ..|.::
Mouse   358 QHRRI--------HTGEKPFKCGECGKSYNQRVHLTQHQRVHTGEKPYKCQVCGKAFRVSSHLVQ 414

  Fly   264 HHVEKYHS-ETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCR--------------------- 306
            ||  ..|| |..:.|..|.|.|.....|..|:|.|..::..:|.
Mouse   415 HH--SVHSGERPYGCNECGKSFGRHSHLIEHLKRHFREKSQRCSDRRSKNTKLNIKQIPGLSEAD 477

  Fly   307 ----------------HS-GCERLFISQRHLM-------------CHEAT--HSGTSSRKSEH-C 338
                            || |||.....|..:|             |:|.:  |..:|..:..| |
Mouse   478 LELSGEVQRNACQAEGHSEGCEHQDGQQGVVMKETLGQSSSKRTDCNEFSYVHKKSSPGERPHQC 542

  Fly   339 GFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLC 403
            ..|||:||....|..| .|.|.||||::|..|.:   || .:|:|:.:.||.: |..:...|.||
Mouse   543 NECGKSFIQSAHLIQH-RRIHTGEKPFRCEECGK---SY-NQRVHLTQHHRVH-TGEKPYACHLC 601

  Fly   404 RQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHA 468
            .:.|.....|:.|.|....:||                       |:|..|.:.|..:|.|..|.
Mouse   602 GKAFRVRSHLVQHQSVHSRERP-----------------------FKCNECGKGFGRRSHLAGHL 643

  Fly   469 AVHSEKDRPHACPHCSKRFKR----------------------AQDMKWHI------KTHEKEKP 505
            .:|| :|:.|.|..|.:.|.:                      .:...|::      |...:|:|
Mouse   644 RLHS-RDKSHQCHECGEIFFQYVSLLEHQVLHVGQKSEKNGICEEAYSWNLTVIKDKKLELQEQP 707

  Fly   506 NVCDVCGKAFALKYVLTQHRLSHEVLE---------------------------KNFKCNVCGRA 543
            ..||.|||||:....|.||..:|...:                           |:.:||.|||.
Mouse   708 YQCDSCGKAFSYSSDLIQHYRTHSAEKPQKCDACRDSTCQCPHIKQQQKSCPSGKSHQCNECGRG 772

  Fly   544 YLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQP 591
            :..:..|..|||.|||:...:|..|...|.....|..|: ::|..:.|
Mouse   773 FSLKSHLSQHQRIHTGEKPLQCKECGMSFSWSCSLFKHL-RSHERTDP 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	18/80 (23%)
		COG5048	198..>508	CDD:227381	93/393 (24%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	8/20 (40%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	10/74 (14%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/47 (11%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zkscan5	NP_057892.2	SCAN	47..155	CDD:128708	12/42 (29%)
		SCAN	47..134	CDD:280241	6/20 (30%)
		KRAB	220..251	CDD:279668	1/30 (3%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..263		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	283..340		7/56 (13%)
		COG5048	323..744	CDD:227381	108/460 (23%)
		C2H2 Zn finger	343..363	CDD:275368	5/27 (19%)
		zf-H2C2_2	355..380	CDD:290200	7/32 (22%)
		C2H2 Zn finger	371..391	CDD:275368	5/19 (26%)
		zf-H2C2_2	383..406	CDD:290200	9/22 (41%)
		C2H2 Zn finger	399..419	CDD:275368	8/21 (38%)
		C2H2 Zn finger	427..447	CDD:275368	7/19 (37%)
		zf-C2H2	540..562	CDD:278523	10/22 (45%)
		C2H2 Zn finger	542..562	CDD:275368	9/20 (45%)
		zf-H2C2_2	554..579	CDD:290200	12/29 (41%)
		C2H2 Zn finger	570..590	CDD:275368	8/23 (35%)
		zf-H2C2_2	582..605	CDD:290200	7/23 (30%)
		C2H2 Zn finger	598..618	CDD:275368	7/19 (37%)
		C2H2 Zn finger	626..646	CDD:275368	6/19 (32%)
		C2H2 Zn finger	654..674	CDD:275368	3/19 (16%)
		C2H2 Zn finger	710..730	CDD:275368	10/19 (53%)
		C2H2 Zn finger	766..786	CDD:275368	9/19 (47%)
		zf-H2C2_2	778..802	CDD:290200	9/23 (39%)
		C2H2 Zn finger	794..814	CDD:275368	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100