DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp85

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_036013928.1	Gene:	Zfp85 / 22746	MGIID:	107767	Length:	481	Species:	Mus musculus

Alignment Length:	480	Identity:	132/480 - (27%)
Similarity:	195/480 - (40%)	Gaps:	78/480 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 FVD-AVDIDEAEEEEEEEEQQQQYDEEVEEPITD----ESAPPQLTISYACKFCLRPQENYQLQQ 203
            |.| |:|....|.|..:..|...|.|.:.|..::    .|.|      :.||.|   .:.:....
Mouse    47 FTDVAIDFSADECECLDSAQWNLYKEVMLENYSNLVFLGSKP------HKCKEC---GKAFDRNS 102

  Fly   204 LLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEK 268
            :|::| ...|..|:.|.|.||...|..::|...|.:....||.:.|.||||.:.....|..|...
Mouse   103 VLIQH-QRIHTGERSYKCEECGKSFNYSSSFKQHQRIHTGEKPYKCEVCGKAFNCSSYLGKHQRI 166

  Fly   269 YHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSR 333
            :..|..::|..|.|.|.....|..|.:.|..::.:||..  |.:.|.....|..|:..|:|....
Mouse   167 HTGEKRYKCEECGKPFTNCSGLIVHRRVHTGEKPYKCEE--CGKAFSVGTTLSNHQRIHTGEKPY 229

  Fly   334 KSEHCGF-------------------------CGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEV 373
            |.|.||.                         |||.|....:|..| .:.|.|||.|||.:|.:.
Mouse   230 KCEECGMAFNVRFLLSKHQQTHTGEKPYKCKECGKAFNCSSSLHQH-QQIHRGEKLYKCDDCGQA 293

  Fly   374 F--ASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRV 436
            |  :||       |.:||...|.::.|:|..|.:.|....:||:|......::|
Mouse   294 FSCSSY-------LYKHRRIHTGMKPSKCKECGKTFYCSVNLIYHQRIHTGEKP----------- 340

  Fly   437 LQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHE 501
                        ::|..|.:.|::.|...:|..:|| .::|:.|..|.|.|....::..|.:.|.
Mouse   341 ------------YKCNECGKAFSIYSRFMKHQRIHS-GEKPYKCKECEKAFNNCYNLIQHQRIHT 392

  Fly   502 KEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCD 566
            .|||..|..|||||.....|.||...| ..||.:||..||:|:....:|:.|.|.|||:..|||:
Mouse   393 GEKPYKCKDCGKAFHYTSSLAQHERIH-TGEKPYKCEECGKAFNSSSNLKNHWRLHTGEKPYKCE 456

  Fly   567 LCQERFVTHIKLKTHMQKAHAASQP 591
            .|.:.|........| .:.|....|
Mouse   457 QCGKAFKDCSSFTRH-YRIHTRENP 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	86/336 (26%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	8/45 (18%)
		C2H2 Zn finger	367..384	CDD:275368	5/18 (28%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
Zfp85	XP_036013928.1	KRAB	45..>90	CDD:214630	12/48 (25%)
		C2H2 Zn finger	91..111	CDD:275368	5/23 (22%)
		COG5048	115..480	CDD:227381	112/400 (28%)
		C2H2 Zn finger	119..139	CDD:275368	6/19 (32%)
		C2H2 Zn finger	147..167	CDD:275368	7/19 (37%)
		C2H2 Zn finger	175..195	CDD:275368	6/19 (32%)
		C2H2 Zn finger	203..223	CDD:275368	5/21 (24%)
		C2H2 Zn finger	231..251	CDD:275368	3/19 (16%)
		C2H2 Zn finger	259..279	CDD:275368	6/20 (30%)
		C2H2 Zn finger	287..307	CDD:275368	8/26 (31%)
		C2H2 Zn finger	315..335	CDD:275368	6/19 (32%)
		C2H2 Zn finger	343..363	CDD:275368	5/19 (26%)
		C2H2 Zn finger	371..391	CDD:275368	5/19 (26%)
		C2H2 Zn finger	399..419	CDD:275368	9/19 (47%)
		C2H2 Zn finger	427..447	CDD:275368	7/19 (37%)
		C2H2 Zn finger	455..475	CDD:275368	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100