DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp59

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_035892.2	Gene:	Zfp59 / 22717	MGIID:	99206	Length:	653	Species:	Mus musculus

Alignment Length:	475	Identity:	133/475 - (28%)
Similarity:	201/475 - (42%)	Gaps:	57/475 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 EEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCP 222
            :.:..||..::|...|.|.::........|.||.|   .:.:..:..|.:| .:.|..|:||.|.
Mouse   143 QSDAGQQITNKEGVPPHTCQTLAHNTEKPYECKEC---GKCFGCRSTLTQH-QSVHTGEKPYECK 203

  Fly   223 ECEARFQDAASRTVHLKSSHVEK-----------QH-----------------ACGVCGKKYGDR 259
            ||...|:.....|.|.|....||           ||                 ||..|||.:...
Mouse   204 ECGKAFRLPQQLTRHQKCHSGEKPFSHNEGRQAFQHPNLLKYPKAIHTGAKAFACRECGKSFNRV 268

  Fly   260 HNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHE 324
            .:|..|...:.....:||..|.|.|...:|...|.|.|:.:|.|:|:  .|.:.||...||..|:
Mouse   269 SSLVEHGLIHADVKPYECNECGKAFKRHRSFVRHQKIHSGERPFQCK--DCGKGFIVLAHLTRHQ 331

  Fly   325 ATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHM-LERH 388
            ::|   |..|...|..|||.|...:.|..| .|.|.||||::|..|...|      |:.: |..|
Mouse   332 SSH---SEEKPFECEECGKKFRTARHLVKH-QRIHSGEKPFECNVCGSAF------RLQLYLSEH 386

  Fly   389 RENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRP------GAPIIANNKRVLQQKRERQYSG 447
            ::.....:..||.:|.:.|..:..|..|:.....:.|      |:..  .||..|.:.......|
Mouse   387 QKTHMEEKYLECNVCGKAFRLQVYLSEHLKTHTEENPFKCKLCGSAF--PNKYQLNKHLTVHTDG 449

  Fly   448 L-FQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVC 511
            . :||..|.:.|..:|.|..|.::|:.| :|..|..|.|.|:....:..|.|:|..|:|..|..|
Mouse   450 KPYQCKECGKCFRQRSKLTEHESIHTGK-KPFQCEECGKFFRLNTLLIHHQKSHSGERPFECKEC 513

  Fly   512 GKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHI 576
            ||||.|...|..|::.| ..::.|:|.|||:::..|.:|..|...|.|...|:|..|.:.|: |.
Mouse   514 GKAFLLPSQLNSHKIVH-TSKRPFECKVCGKSFKRESNLIQHGAVHAGVKSYECSECGKGFI-HR 576

  Fly   577 KLKTHMQKAHAASQPHSADQ 596
            ....|.:|.|:..:|....:
Mouse   577 SSLFHHRKIHSDEKPFKCQE 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	95/345 (28%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp59	NP_035892.2	KRAB	14..75	CDD:214630
		COG5048	167..554	CDD:227381	116/406 (29%)
		C2H2 Zn finger	174..194	CDD:275368	5/23 (22%)
		C2H2 Zn finger	202..222	CDD:275368	7/19 (37%)
		C2H2 Zn finger	258..278	CDD:275368	6/19 (32%)
		C2H2 Zn finger	286..306	CDD:275368	7/19 (37%)
		C2H2 Zn finger	314..334	CDD:275368	7/21 (33%)
		C2H2 Zn finger	342..362	CDD:275368	8/20 (40%)
		C2H2 Zn finger	370..390	CDD:275368	6/25 (24%)
		C2H2 Zn finger	398..418	CDD:275368	5/19 (26%)
		C2H2 Zn finger	426..446	CDD:275368	4/21 (19%)
		C2H2 Zn finger	454..474	CDD:275368	6/19 (32%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		C2H2 Zn finger	510..530	CDD:275368	9/19 (47%)
		C2H2 Zn finger	538..558	CDD:275368	7/19 (37%)
		C2H2 Zn finger	566..586	CDD:275368	6/20 (30%)
		C2H2 Zn finger	594..614	CDD:275368	0/3 (0%)
		C2H2 Zn finger	622..642	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100