DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp54

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001366288.1	Gene:	Zfp54 / 22712	MGIID:	99201	Length:	625	Species:	Mus musculus

Alignment Length:	594	Identity:	150/594 - (25%)
Similarity:	231/594 - (38%)	Gaps:	99/594 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 IRLQFANW-NLKISPNDGLPQKICSDCFTKFCSINAFRLACQEAQLKLSH-----IYDKIDASSL 99
            |.:...|: ||....|..:...:|....|:       :.:|.|....|..     :|::.|.:..
Mouse    79 IEVMLENYSNLVYVENYCICDTVCQHVKTE-------KESCNELGEMLHEPSNCALYNRSDTTEA 136

  Fly   100 EDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQ 164
            .::....:|.:.:.:....:..|.|.|.....:..:.|..  .....::..|:......:|::|:
Mouse   137 SNNYRCCKDQDASLDSSNPDRLKSTHTGKERCESKDCAKS--SSLCSSIAQDQRTNSTNKEQRQE 199

  Fly   165 QYDEEV--------------EEP--------------------ITDESAPPQLTISYACKFCLRP 195
            :||:..              |.|                    .||....|     |.|..|
Mouse   200 KYDDHFISTHSLMQQAIYIGENPHQCMKYGKCFSSASSLGVQQRTDTGNKP-----YKCNIC--- 256

  Fly   196 QENYQLQQLLLEHINASHD----PEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKY 256
            .:::.....|.|| ..:|.    ...||.|.:|...|...::...|.|....||::.|..|||.|
Mouse   257 DKSFTECSSLKEH-RKTHQRLRAGTNPYKCNDCGKSFSYLSALQSHHKRHTGEKRYKCKECGKSY 320

  Fly   257 GDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLM 321
            ..|..|:.|.:.:.:|..:.|..|.|.|:.......|...|..::.:||..  |.|.|.......
Mouse   321 AYRTGLKRHQKIHTAEECYSCQYCGKVFHQLSHFKSHFTLHTGEKPYKCNE--CHRSFPHYVFFR 383

  Fly   322 CHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLE 386
            .|:..|   |.:||..|..|||:|..|..|:.| ||.|.|||||||..|.::|..|:.     |.
Mouse   384 RHKKNH---SLQKSHKCKECGKSFFILSHLKTH-YRIHTGEKPYKCTKCDKLFTQYSH-----LR 439

  Fly   387 RHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQC 451
            ||:...|..:...|.:|.:.|:....|..|                      ||...: :..::|
Mouse   440 RHQRIYTGKKLYRCEVCDKWFTLSSSLSRH----------------------QKIHTE-AKTYKC 481

  Fly   452 GSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFA 516
            ..|...||..|:|.||..||: .:|.:.|..|.|.|.|...::.|.:.|..|||..|..|.|:|.
Mouse   482 KDCDIFFNHYSSLRRHQKVHT-GERHYTCKQCGKSFTRGSTLRVHQRIHTGEKPYKCSECDKSFT 545

  Fly   517 LKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTH 581
            ....|..|:..| ..||.:.|..||::......||.||:.|||:..|||..|...::.:..||.|
Mouse   546 QASQLRTHQRVH-TGEKPYVCKECGKSLTTCAILRAHQKIHTGEKPYKCMECDRSYIQYSHLKRH 609

  Fly   582 MQKAHAASQ 590
             ||.|...:
Mouse   610 -QKVHTGEK 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	9/46 (20%)
		COG5048	198..>508	CDD:227381	91/313 (29%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp54	NP_001366288.1	KRAB	52..92	CDD:396083	4/12 (33%)
		COG5048	138..544	CDD:227381	112/451 (25%)
		C2H2 Zn finger	225..245	CDD:275368	0/19 (0%)
		C2H2 Zn finger	253..273	CDD:275368	5/23 (22%)
		C2H2 Zn finger	285..305	CDD:275368	5/19 (26%)
		C2H2 Zn finger	313..333	CDD:275368	8/19 (42%)
		C2H2 Zn finger	341..361	CDD:275368	5/19 (26%)
		C2H2 Zn finger	397..417	CDD:275368	10/20 (50%)
		C2H2 Zn finger	425..445	CDD:275368	7/24 (29%)
		C2H2 Zn finger	453..473	CDD:275368	7/41 (17%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		SFP1	<531..611	CDD:227516	29/81 (36%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..585	CDD:275368	7/19 (37%)
		C2H2 Zn finger	593..613	CDD:275368	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100