DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp39

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_035888.2	Gene:	Zfp39 / 22698	MGIID:	99183	Length:	718	Species:	Mus musculus

Alignment Length:	572	Identity:	146/572 - (25%)
Similarity:	232/572 - (40%)	Gaps:	133/572 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 TKPTTTVSAE--TQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQY-------DEEVEEPI-- 174
            |||......|  .:|......|.:...|...|.|..|..::.|::..:       ::..||.:
Mouse   103 TKPEVIFKLEQGAEPWRAEDVPKQSRADVQKITELNETSQDNEERHLWHHAITYSNKSTEEKVKL 167

  Fly   175 -----TDESAPPQLTISYACKFCLRPQENYQLQQLLL----------EHINASHDPEQPYN---- 220
                 ...:....||:.......:||......|.:|.          |.::||...|.|.:
Mouse   168 GNIVNVSSNCVSNLTVKNGNSSGMRPVALTVWQSVLPPNKPDDTRIGEELDASLTSEPPIHAEHP 232

  Fly   221 -----CPECEARFQDAASR-TVHLKSSHVEKQH-ACGVCGKKYGDRHNLRHHVEKY-------HS 271
                 .|....:||..... |.:.|:...::.| |.|  ..|:|:...:...|..:       .:
Mouse   233 GLYSRAPGTGQQFQCCMQEVTCNTKALWTKRFHIAHG--SSKFGESEKVPDEVALHAQDVSWVRA 295

  Fly   272 ETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCH--EATHSGTSSRK 334
            || |||::|:|.|.|:..|..|.|.|...:.:.||  .||:.||.:.:   |  :..|:|..|.:
Mouse   296 ET-FECSICKKTFCTKCELMKHKKIHKGQQYYTCR--DCEKTFIKESY---HTDQRVHAGVGSHR 354

  Fly   335 SEHCGFC----GKTFIHLKTLR----WHIY----------------RQHGGEKPYKCANCTEVFA 375
            .:.|..|    .:..:|.:..|    |.:|                |...|.|||.|..|.:.|.
Mouse   355 CKQCEKCFHQKNQQNVHERVPREARLWEVYQSENSFGEKPNLRRYQRTRAGYKPYGCNLCGKAFY 419

  Fly   376 SYA----EKRIHMLER------------HRENLTAIERS-------ECMLCRQPFSSEPDL-IHH 416
            ..:    .::||..|:            |:.:||..:|:       ||..||:.|..:.|| :||
Mouse   420 RKSHLGRHQKIHTGEKPYGCEECKKTFYHKSSLTIHQRTHTGEKPYECKKCRKTFYCKSDLNVHH 484

  Fly   417 MSAEHLQRPGAPIIANNKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHA 479
                                      |.::|  .::|..|.:.|..||.|..|..||: .|:|:.
Mouse   485 --------------------------RTHTGEKPYECDECRKTFYSKSHLVIHQKVHT-GDKPYE 522

  Fly   480 CPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAY 544
            |..|.|.|.|..::..|.|||..|||..|:||||.|..:..|..|:.:| ..:|.::|..||:|:
Mouse   523 CEECQKAFSRKSNLTVHQKTHTGEKPYECNVCGKTFHRQSHLNMHQGTH-TGQKPYQCEECGKAF 586

  Fly   545 LFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            ..:.|||.|||.|||...|.|:.|::.|:....|..| |::|...:|:|.::
Mouse   587 YQKSSLRRHQRNHTGSRPYACEECRKTFLHKSSLTVH-QRSHTGYKPYSCEE 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	96/389 (25%)
		C2H2 Zn finger	221..241	CDD:275368	5/20 (25%)
		C2H2 Zn finger	249..269	CDD:275368	4/19 (21%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	7/23 (30%)
		C2H2 Zn finger	338..359	CDD:275368	7/44 (16%)
		C2H2 Zn finger	367..384	CDD:275368	4/20 (20%)
		C2H2 Zn finger	400..420	CDD:275368	8/20 (40%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	10/19 (53%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp39	NP_035888.2	KRAB	59..118	CDD:214630	4/14 (29%)
		KRAB	59..98	CDD:279668
		C2H2 Zn finger	300..320	CDD:275368	8/19 (42%)
		C2H2 Zn finger	328..347	CDD:275368	7/23 (30%)
		C2H2 Zn finger	355..374	CDD:275370	3/18 (17%)
		COG5048	407..699	CDD:227381	80/260 (31%)
		C2H2 Zn finger	411..431	CDD:275368	3/19 (16%)
		C2H2 Zn finger	439..459	CDD:275368	4/19 (21%)
		zf-H2C2_2	451..474	CDD:290200	7/22 (32%)
		C2H2 Zn finger	467..487	CDD:275368	9/45 (20%)
		zf-H2C2_2	479..502	CDD:290200	8/48 (17%)
		C2H2 Zn finger	495..515	CDD:275368	7/19 (37%)
		zf-H2C2_2	507..532	CDD:290200	10/25 (40%)
		C2H2 Zn finger	523..543	CDD:275368	7/19 (37%)
		zf-H2C2_2	535..560	CDD:290200	13/24 (54%)
		C2H2 Zn finger	551..571	CDD:275368	8/19 (42%)
		zf-H2C2_2	563..586	CDD:290200	7/23 (30%)
		C2H2 Zn finger	579..599	CDD:275368	10/19 (53%)
		zf-H2C2_2	591..616	CDD:290200	13/24 (54%)
		C2H2 Zn finger	607..627	CDD:275368	6/20 (30%)
		C2H2 Zn finger	635..655	CDD:275368	0/3 (0%)
		zf-H2C2_2	647..672	CDD:290200
		C2H2 Zn finger	663..683	CDD:275368
		C2H2 Zn finger	691..711	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100