DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zbtb41

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_766231.2	Gene:	Zbtb41 / 226470	MGIID:	2444487	Length:	908	Species:	Mus musculus

Alignment Length:	645	Identity:	156/645 - (24%)
Similarity:	241/645 - (37%)	Gaps:	187/645 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KISPNDGLPQ---KICSDCFTKFCSINAFRLACQEAQLKLSHIYDKIDASSL------------- 99
            |.||.:.|.:   ::.|....||||    |..|.:..|: :|: .|...|.|
Mouse   190 KSSPEETLNELTGRLSSSHQCKFCS----RHFCYKKSLE-NHL-AKTHRSLLLGKKHGLKMLERS 248

  Fly   100 -------------------EDDEIGQEDLEPAEE-HQETETTKPTTTVSAETQPNNTASDP-IEI 143
                               .|||  ||..:.::. |||:.        ..|....|.:.|| .|.
Mouse   249 FSTRRSKRNRKCPVKFEDTSDDE--QESGDGSDNLHQESS--------EKERSDRNDSEDPGSEY 303

  Fly   144 FVDAVDIDEAEEEEEEEEQQQQYDEEV-EEPITDESA-------PPQLTISYACKFCLRPQENYQ 200
            ..:..:::|...:|:.:.:|...|.:. |||...:||       .|.:..:...|....|:.:..
Mouse   304 NAEDEELEEEVSDEDSDTEQSDKDNDAEEEPEAGDSAGSIHEGLAPVIIQNSNKKILQCPKCDKT 368

  Fly   201 LQQL-LLEHINASHDPEQPYNCPECEARFQDAASRTVHLK--SSHVE---KQHACGVCGKKYGDR 259
            ..:: ..|.....|..|:|:.|..|..|:...::.|||.|  |:.||   |:|.|..|.|.:..:
Mouse   369 FDRIGKYESHTRVHTGEKPFECDICHQRYSTKSNLTVHRKKHSNEVEFHRKEHKCPYCNKLHASK 433

  Fly   260 HNLRHHVEKYHSET-------------DFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCE 311
            ..|..||:::|.|.             .::|.:|:|.|..|..|..||..|:.|:.|||.:  ||
Mouse   434 KTLAKHVKRFHPENAQEFISIKKTKSESWKCDICKKSFTRRPHLEEHMILHSQDKPFKCTY--CE 496

  Fly   312 RLFIS-------------------------------QRHLMCHEATHSGTSSRKSEHCGFCGKTF 345
            ..|.|                               :||:.|   ||.|   ::...|..|||:.
Mouse   497 EHFKSRFARLKHQEKFHLGPFPCDICGRQFNDTGNLKRHIEC---THGG---KRKWTCFICGKSV 555

  Fly   346 IHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSE 410
            ....||:.|: |.|.||||:.|:.|.:.|...:..|:|:
Mouse   556 RERTTLKEHL-RIHSGEKPHLCSICGQSFRHGSSYRLHL-------------------------- 593

  Fly   411 PDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKD 475
              .:||               ::||             ::|..|.:.|.....|.:|..:|| .:
Mouse   594 --RVHH---------------DDKR-------------YECDECGKTFIRHDHLTKHKKIHS-GE 627

  Fly   476 RPHACPHCSKRFKRAQDMKWHIKT-HEKEKP--------NVCDVCGKAFALKYVLTQHRLSHEVL 531
            :.|.|..|.|.|.|...:..|.|: |..||.        :.||||.|.|..|..|..|..:|..
Mouse   628 KAHQCEECGKCFGRRDHLTVHYKSVHLGEKVWQKYKATFHQCDVCKKIFKGKSSLEMHFRTHSG- 691

  Fly   532 EKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQP 591
            ||.:||.:|.:::..:|:|..|...|:....:.|..|...|....|||.|:...|....|
Mouse   692 EKPYKCQICNQSFRIKKTLTKHLVIHSDARPFNCQHCNATFKRKDKLKYHIDHVHGIKSP 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	12/38 (32%)
		COG5048	198..>508	CDD:227381	87/368 (24%)
		C2H2 Zn finger	221..241	CDD:275368	7/21 (33%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	8/52 (15%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	2/19 (11%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	7/20 (35%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	6/16 (38%)
Zbtb41	NP_766231.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..59
		BTB_POZ_ZBTB41	67..180	CDD:349535
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..344		22/101 (22%)
		CobT	<270..>339	CDD:130712	19/78 (24%)
		C2H2 Zn finger	362..382	CDD:275368	2/19 (11%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	423..441	CDD:275368	5/17 (29%)
		C2H2 Zn finger	464..484	CDD:275368	8/19 (42%)
		C2H2 Zn finger	492..509	CDD:275368	5/18 (28%)
		C2H2 Zn finger	519..540	CDD:275368	3/23 (13%)
		C2H2 Zn finger	548..568	CDD:275368	8/20 (40%)
		zf-H2C2_2	561..585	CDD:372612	11/24 (46%)
		C2H2 Zn finger	576..596	CDD:275368	5/47 (11%)
		zf-C2H2	602..624	CDD:333835	5/21 (24%)
		C2H2 Zn finger	604..624	CDD:275368	5/19 (26%)
		zf-H2C2_2	616..641	CDD:372612	9/25 (36%)
		C2H2 Zn finger	632..650	CDD:275368	6/17 (35%)
		C2H2 Zn finger	669..686	CDD:275368	8/16 (50%)
		C2H2 Zn finger	697..717	CDD:275368	5/19 (26%)
		C2H2 Zn finger	725..742	CDD:275368	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4053
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950