DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp472

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_694703.2	Gene:	Zfp472 / 224691	MGIID:	2385049	Length:	534	Species:	Mus musculus

Alignment Length:	528	Identity:	134/528 - (25%)
Similarity:	203/528 - (38%)	Gaps:	123/528 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 EIFVDAVDIDEAEEEEEEEEQQQ--------------QYD---------EEVEEPITDESAPPQL 183
            |.|::.:.|.:.|||:.|||.|.              :||         ::..|.:.:|..||.:
Mouse    41 ETFLNLISIGKTEEEDTEEEYQNPKGNLRTLMVERLCKYDYGNQYGETHQQSPEHVANEKMPPAI 105

  Fly   184 TI--------------------SYACKF------CLRPQ---ENYQLQQLLLEH----------- 208
            |.                    ..:|::      .|:.:   :::...:||..|
Mouse   106 TECERDICTHLPSDMHFKGQTGKKSCQYQEHTEKALKHKNCWKDFTYSELLWMHKSPPMRQKPYE 170

  Fly   209 ----------INASHD------PEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYG 257
                      ....||      .|:.|.|.:|...:.|:.|...|.:|...||:|.|..|||.:.
Mouse   171 DKQGTEASRSFTTDHDYEGAYTEEKSYICKQCGKAWSDSCSLLWHERSHIQEKRHTCKQCGKAFS 235

  Fly   258 DRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMC 322
            ....|..|...:..|..:.|..|.|.|..|::.:.|.:.|...:.|.|:.  |.:.|:....|:.
Mouse   236 RPSQLHKHERIHTGEKPYVCTHCGKAFIDRRTCHNHERTHTGVKPFACKQ--CGKAFLRSCQLLI 298

  Fly   323 HEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLER 387
            ||..|:|   .:...|..|||.|.:.....:| .|.|.||||..|..|.:.|...|...||
Mouse   299 HERIHTG---ERPFVCKHCGKAFTYSSACYYH-ERIHTGEKPCVCKQCGKAFKCSAYLHIH---- 355

  Fly   388 HRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSG--LFQ 450
                    |||..       ..:|.:..|.........|.           .|.||.::|  .:.
Mouse   356 --------ERSHS-------GEKPYVCKHCGKAFAYATGC-----------HKHERIHTGEKPYM 394

  Fly   451 CGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAF 515
            |..|.:.|....:|..|...|| .::|:.|..|.|.|.:...::.|.:.|..|||.||..|||||
Mouse   395 CVQCGKLFTFPRSLHIHERSHS-GEKPYVCKQCGKSFTQGTSLRRHERIHTGEKPYVCKQCGKAF 458

  Fly   516 ALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKL-- 578
            ..:.....|..:| ..||.|.|..||:.:.|.|||::|::.|||:..|.|..|.:.|.....|
Mouse   459 IQRDDCYSHERTH-TGEKPFMCVQCGKTFTFSKSLQIHEKNHTGEKPYICKQCGKAFTCSTYLLR 522

  Fly   579 --KTHMQK 584
              :||.:|
Mouse   523 HERTHSEK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	84/338 (25%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	2/19 (11%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	5/20 (25%)
Zfp472	NP_694703.2	KRAB	10..>50	CDD:214630	2/8 (25%)
		KRAB	10..49	CDD:279668	2/7 (29%)
		COG5048	195..>492	CDD:227381	95/334 (28%)
		C2H2 Zn finger	199..219	CDD:275368	5/19 (26%)
		C2H2 Zn finger	227..247	CDD:275368	6/19 (32%)
		C2H2 Zn finger	255..275	CDD:275368	6/19 (32%)
		C2H2 Zn finger	283..303	CDD:275368	6/21 (29%)
		zf-H2C2_2	296..320	CDD:290200	10/26 (38%)
		C2H2 Zn finger	311..331	CDD:275368	7/20 (35%)
		C2H2 Zn finger	339..359	CDD:275368	8/31 (26%)
		C2H2 Zn finger	367..387	CDD:275368	5/30 (17%)
		C2H2 Zn finger	395..415	CDD:275368	5/19 (26%)
		C2H2 Zn finger	423..443	CDD:275368	5/19 (26%)
		zf-H2C2_2	435..460	CDD:290200	12/24 (50%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	479..499	CDD:275368	8/19 (42%)
		zf-H2C2_2	491..516	CDD:290200	10/24 (42%)
		C2H2 Zn finger	507..527	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100