DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp7

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001345745.1	Gene:	Zfp7 / 223669	MGIID:	99208	Length:	685	Species:	Mus musculus

Alignment Length:	542	Identity:	155/542 - (28%)
Similarity:	221/542 - (40%)	Gaps:	91/542 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 EIGQE----DLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQ 163
            |.|||    ||:.||   .||..:...|.|                  |:..|..:..|.....|
Mouse    58 EQGQEPWVLDLQGAE---GTEAPRICQTDS------------------AIRTDRKQTCEYTSLLQ 101

  Fly   164 QQ---YDEEVEEPITDESAPPQLTISYACKF---------CLRP--------QENYQLQQLLL-- 206
            :|   :.:.::..:..|:.|..|.:|.:...         .:.|        ||..:||...:
Mouse   102 RQIPGFGDNLDSKVWSENCPRSLGLSVSGSLFQKHRLNSEAVMPKNSTKDAVQERKELQATDVGY 166

  Fly   207 ------EHINAS-------HDPEQPYNCPECEARFQDAASRTVHLKSSHV-EKQHACGVCGKKYG 257
                  :|:::.       ...|..|.|.||...|:..:....| |.||. ||.:.|..|.|.:.
Mouse   167 RPDDQRDHLSSKLIRRQSVPTGENRYPCEECGKAFRWRSRLNQH-KLSHTGEKSYQCNKCTKVFA 230

  Fly   258 DRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMC 322
            ....|..|...:..|..|:|..|.|||.....|..|.:.|..:|.|||  :.|.:.|.....|:.
Mouse   231 SSSRLIRHQRAHTGEKPFKCDQCGKRFVLASVLTQHQRIHTGERPFKC--AECGKGFHLSAKLVQ 293

  Fly   323 HEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLER 387
            |:..|:|   .|...|..|||||....:|..| .|.|.||:|:.|..|.:.|...::     |.|
Mouse   294 HQRIHTG---EKPYRCEECGKTFGQSSSLVHH-QRIHTGERPFICQECGKAFCQRSQ-----LSR 349

  Fly   388 HRENLTAIERSECMLCRQPFSSEPDLIHHM----SAEHLQRPGA----PIIANNKRVLQQKRERQ 444
            ||...|......|..|.:.|.....|..|.    :||..|.|.|    .:||......::|.
Mouse   350 HRRTHTGERPYSCQECGKAFCQRATLAQHQKMMHTAEKSQMPRASESPSLIACQGNTTEEKP--- 411

  Fly   445 YSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCD 509
                |:|..|.:.|...|.|.:|..||| .::|:.|..|||.|.....:..|.:||..|||..||
Mouse   412 ----FKCEQCGKAFRWLSRLNQHQVVHS-GEKPYQCNKCSKAFGCTSRLIRHQRTHTGEKPFKCD 471

  Fly   510 VCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVT 574
            .|||.|.....|.||:..| ..||.:.|:.||||:....||..|||.|.|:..|||..|.:.|..
Mouse   472 ECGKRFVQSSHLIQHQRIH-TGEKPYVCDDCGRAFTQSSSLIYHQRIHKGEKPYKCSQCGKAFSM 535

  Fly   575 HIKLKTHMQKAHAASQPHSADQ 596
            ..:|.:| |:.|...:|::.::
Mouse   536 STQLTSH-QRTHTGERPYTCNE 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	97/333 (29%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	5/23 (22%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	10/19 (53%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp7	NP_001345745.1	KRAB	4..65	CDD:214630	4/6 (67%)
		C2H2 Zn finger	194..214	CDD:275368	6/20 (30%)
		C2H2 Zn finger	222..242	CDD:275368	5/19 (26%)
		COG5048	246..668	CDD:227381	110/332 (33%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		C2H2 Zn finger	278..298	CDD:275368	5/21 (24%)
		C2H2 Zn finger	306..326	CDD:275368	9/20 (45%)
		C2H2 Zn finger	334..354	CDD:275368	7/24 (29%)
		C2H2 Zn finger	362..380	CDD:275368	5/17 (29%)
		C2H2 Zn finger	414..434	CDD:275368	6/19 (32%)
		C2H2 Zn finger	442..462	CDD:275368	6/19 (32%)
		C2H2 Zn finger	470..490	CDD:275368	9/19 (47%)
		C2H2 Zn finger	498..518	CDD:275368	10/19 (53%)
		C2H2 Zn finger	526..546	CDD:275368	6/20 (30%)
		C2H2 Zn finger	554..574	CDD:275368	0/3 (0%)
		C2H2 Zn finger	582..602	CDD:275368
		C2H2 Zn finger	635..655	CDD:275368
		C2H2 Zn finger	663..683	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100