DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp583

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_030098197.1	Gene:	Zfp583 / 213011	MGIID:	2682297	Length:	608	Species:	Mus musculus

Alignment Length:	525	Identity:	138/525 - (26%)
Similarity:	216/525 - (41%)	Gaps:	94/525 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 SHIYDKIDASSLEDD---------EIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPI-- 141
            ||....:|...|::|         .:|::::   ..||...|.|...  .:|.:..|.:...:
Mouse   147 SHFSSSLDCPDLKEDHENEDWFKNRLGRQEV---HSHQLFITHKEVP--ESEIRGCNPSCQAVHQ 206

  Fly   142 EIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLL 206
            ...:|.......:|..::.|.|::                    ||..|......:..|:::.:|
Mouse   207 NAILDVPQCSSTKERIDQSEPQKR--------------------SYRKKSVEMKHKKVQVEKRIL 251

  Fly   207 EHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHS 271
            :             |.|||..|...:|.|:|.:....||.:||..|||.:....||..|...:..
Mouse   252 K-------------CSECEKVFNQTSSLTLHQRIHTGEKPYACVECGKAFSQSANLAQHKRIHTG 303

  Fly   272 ETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSE 336
            |..:||..|.|.|.....|..|.:.|..::.::|:.  |::.|....||..|:..|:|   .:..
Mouse   304 EKPYECKECRKAFSQNAHLAQHQRVHTGEKPYQCKE--CKKAFSQIAHLTQHQRIHTG---ERPF 363

  Fly   337 HCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFAS----YAEKRIHMLERHRENLTAIER 397
            .|..|||.|.:...|..| .|.|.|||||.|..|.:.|:.    ...:|||..||         .
Mouse   364 ECIECGKAFSNGSFLAQH-QRIHTGEKPYVCHVCGKAFSHRGYLIVHQRIHTGER---------P 418

  Fly   398 SECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKS 462
            .||..||:.||....|..|......::|                       ::|..|.:.|:..:
Mouse   419 YECKECRKSFSQYAHLSQHQRVHTGEKP-----------------------YECKVCRKAFSQVA 460

  Fly   463 ALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLS 527
            .|::|..||: .::|:.|..|.|.|..:..:..|.::|..|||.:|..|.|.|:....|.||:..
Mouse   461 YLDQHQRVHT-GEKPYECAECRKAFSNSSSLAQHQRSHTGEKPYICKECRKTFSQNAGLAQHQRI 524

  Fly   528 HEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592
            | ..||.::||:||:|:.:..||.||||.|||:..|:|..|::.|.....| .|.:|.|......
Mouse   525 H-TGEKPYECNICGKAFSYSGSLTLHQRIHTGERPYECKDCRKSFRQRAHL-AHHEKVHTMESFL 587

  Fly   593 SADQP 597
            |...|
Mouse   588 SLSSP 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	85/313 (27%)
		C2H2 Zn finger	221..241	CDD:275368	8/19 (42%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	11/19 (58%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp583	XP_030098197.1	KRAB	45..106	CDD:214630
		COG5048	240..581	CDD:227381	116/394 (29%)
		C2H2 Zn finger	253..273	CDD:275368	8/19 (42%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		C2H2 Zn finger	309..329	CDD:275368	6/19 (32%)
		C2H2 Zn finger	337..357	CDD:275368	6/21 (29%)
		C2H2 Zn finger	365..385	CDD:275368	8/20 (40%)
		C2H2 Zn finger	393..413	CDD:275368	4/19 (21%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		C2H2 Zn finger	449..469	CDD:275368	5/19 (26%)
		C2H2 Zn finger	477..497	CDD:275368	5/19 (26%)
		C2H2 Zn finger	505..525	CDD:275368	7/19 (37%)
		C2H2 Zn finger	533..553	CDD:275368	11/19 (58%)
		C2H2 Zn finger	561..581	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100