DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Gm4767

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_011241947.1	Gene:	Gm4767 / 210583	MGIID:	3644409	Length:	578	Species:	Mus musculus

Alignment Length:	606	Identity:	162/606 - (26%)
Similarity:	247/606 - (40%)	Gaps:	98/606 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 IRLQFANWNLKISPNDG---LPQKICSDCFTKFCSINAFRLACQEAQLKLSHIYDKIDASSLEDD 102
            :|...||.:|:...:.|   .|..:..||.::..|..:..|.|           |::..:.....
Mouse    20 LRASLANQSLEAHFSGGGNIRPAILRFDCESEGSSSVSRALRC-----------DRLLGAVRRAG 73

  Fly   103 EIG--------QEDLEPAEEHQETETTKPT-----TTVSAETQPNNTASDPIEIFVDAVDIDEAE 154
            |:|        .||:.....|:|.....|:     ..|..||..|.||     |.....| |..|
Mouse    74 ELGIRAMDAVTYEDVYVKFTHEEWALLDPSQKSLYKDVMLETCRNLTA-----IGYKLQD-DNIE 132

  Fly   155 EEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPY 219
            |.........:|:....:|...:        .|..|.|...|:.:      |:........|:||
Mouse   133 EHCPSSRGCGRYNIYGYKPCEHK--------GYGKKQCTFAQKRF------LQTYERICSEEKPY 183

  Fly   220 NCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRF 284
            .|.:|...|.:..|...|.|:...||.:.|..|||.:..|..|:.|...:..|..|:|:.|.|.|
Mouse   184 ECNQCSKAFANFRSLQKHEKNHTREKPYECNHCGKAFPSRSALQIHQRTHTGEKPFDCSECGKAF 248

  Fly   285 YTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLK 349
            ....:|:.|.:.|..::.:.|..  |.:.|.::.||..||..|:|   .|...|..|||.|.:..
Mouse   249 ARHSNLDIHKRTHTGEKPYDCNE--CGKAFSTRSHLQIHEIIHTG---EKPYVCNQCGKAFAYRS 308

  Fly   350 TLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLI 414
            .|..| .:.|.|||||:|..|..|:||.:..|.|  |:|.   |..:...|..|.:.|:....|.
Mouse   309 NLEAH-EKTHTGEKPYECNQCGNVYASRSSLRNH--EKHH---TGEKLYGCNQCGKAFARRSSLE 367

  Fly   415 HHMSAEHLQRPGAPIIANN------KRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVH 471
            .|   |.......|.:.|.      :|...|..||.::|  .::|..|.:.|..:::|:.|.. |
Mouse   368 IH---ERTHTGEKPYVCNQCCKAFARRSSLQIHERSHTGEKPYECNQCGKAFASRTSLQNHEK-H 428

  Fly   472 SEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSH--EVL--- 531
            ...::|:.|..|.|.|:...|::.|.:.|..|||.||:.|||||..:..|..|...|  |.|
Mouse   429 HTGEKPYGCNQCDKAFELKCDLQIHERIHTGEKPYVCNQCGKAFVSRRYLRNHEKHHTLEKLYDC 493

  Fly   532 ----------------------EKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVT 574
                                  ||.:||..||:|:.:..:|..|:|:|||:..|:|:.|.:.|..
Mouse   494 SQCGKSFAIFRYLQKHKKTHTGEKPYKCTHCGKAFAYRSNLYRHERSHTGEKLYECNECGKAFAY 558

  Fly   575 HIKLKTHMQKAHAASQPHSAD 595
            |..|..| :|.|....|:..:
Mouse   559 HTSLHNH-KKCHIGENPYECN 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	11/48 (23%)
		COG5048	198..>508	CDD:227381	91/317 (29%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	6/16 (38%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Gm4767	XP_011241947.1	KRAB	83..123	CDD:366587	11/44 (25%)
		COG5048	181..537	CDD:227381	109/370 (29%)
		C2H2 Zn finger	185..205	CDD:275368	6/19 (32%)
		C2H2 Zn finger	213..233	CDD:275368	7/19 (37%)
		C2H2 Zn finger	241..261	CDD:275368	6/19 (32%)
		C2H2 Zn finger	269..289	CDD:275368	7/21 (33%)
		C2H2 Zn finger	297..317	CDD:275368	7/20 (35%)
		C2H2 Zn finger	325..345	CDD:275368	8/21 (38%)
		C2H2 Zn finger	353..373	CDD:275368	6/22 (27%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		C2H2 Zn finger	409..429	CDD:275368	5/20 (25%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		C2H2 Zn finger	465..485	CDD:275368	8/19 (42%)
		C2H2 Zn finger	493..513	CDD:275368	0/19 (0%)
		C2H2 Zn finger	521..541	CDD:275368	7/19 (37%)
		zf-H2C2_2	533..558	CDD:372612	10/24 (42%)
		C2H2 Zn finger	549..569	CDD:275368	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100