DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp871

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_766046.3	Gene:	Zfp871 / 208292	MGIID:	1921793	Length:	615	Species:	Mus musculus

Alignment Length:	659	Identity:	157/659 - (23%)
Similarity:	245/659 - (37%)	Gaps:	175/659 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ETCRTCAISMFVCDFENGSN-NSHFLDLHHPNCWPSEMAQIRLQFANWNLKISPNDGLPQKICSD 65
            ||.|..|        ..||: ..|.::..:.|.|.....|:             .:||..  |.|
Mouse    35 ETLRNLA--------SIGSSLEHHIIENIYRNSWKKLSGQV-------------VEGLYD--CKD 76

  Fly    66 ---C-----FTKFCSINAFRL----ACQE---AQLKLSHIYDKI------DASSLEDDEIGQE-- 107
               |     ||....:|...|    .|:.   |.:.:.|:...:      ...|.||.|.|:|
Mouse    77 DHQCAEIFDFTTHSIVNQNSLPGVYICENSGCATVVIGHLSLSVLLKPDPKHESCEDQEYGKELY 141

  Fly   108 DLE---PAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEE 169
            ::|   |:......|..:.|.||                        |...:.|..::..:|.:.
Mouse   142 NMEYGAPSSSLTSFENYESTYTV------------------------ERIYKTERCDEDYRYGQN 182

  Fly   170 VEEPITDESAPPQLTISYACKFC----------------LRPQENYQLQQ--------LLLEHIN 210
            ||:..|:|.       .:.||.|                .|.::.|..:|        ..|:...
Mouse   183 VEKTFTEEK-------PFECKQCGKCFSSSRYFRRHERRHRAKKCYICKQCGKAFAFPTYLQTHE 240

  Fly   211 ASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDF 275
            ..|..|:||.|.:|...|..:.|...|.::..|.....|..|||......:|:.|...:..|..:
Mouse   241 RIHTGEKPYVCLQCGKTFAHSRSLKTHKRTHSVRDLFVCNYCGKTLRHYSSLQIHTRIHTGEKPY 305

  Fly   276 ECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGF 340
            .|..|.|.|.|.:|...|.:.|..:..::|:.  |...|:....|..||..|||.   |...|..
Mouse   306 VCKPCGKAFITYRSFRIHERIHTGETPYECKQ--CGNTFMRWIQLRKHEIIHSGV---KPYACKL 365

  Fly   341 CGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQ 405
            |||:|....:||.| .|.|.||:||.|..|     .|:..|::.|.||:
Mouse   366 CGKSFTCSGSLRTH-ERIHTGERPYVCDQC-----GYSFTRLNSLLRHK---------------- 408

  Fly   406 PFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAV 470
                    |.|..    ::|                       :.|..|.:.|...::|:||..:
Mouse   409 --------ITHTG----EKP-----------------------YVCNHCGKTFPRSASLQRHVKI 438

  Fly   471 HSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNF 535
            |:| ::|:.|..|...|..:.|:..|.:||..|||.:|:.||.||.|.....:|:..|.| ..::
Mouse   439 HTE-EKPYVCKQCGVAFPSSADLLEHEQTHIDEKPYICEQCGNAFVLWSQFQKHKALHAV-PVSY 501

  Fly   536 KCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ---- 596
            .|..||:::...:||:.|:|.|||:..|:|..|.:.|:....|:.| :|.|...:.|...|
Mouse   502 VCKQCGKSFTSSRSLKTHERIHTGEKPYECKQCGKTFLWSYSLQRH-EKTHTDGKVHVCKQCGET 565

  Fly   597 -PLDDLINI 604
             |.|..:.:
Mouse   566 FPYDSHLQV 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	20/99 (20%)
		COG5048	198..>508	CDD:227381	81/317 (26%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	2/19 (11%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp871	NP_766046.3	KRAB	4..>44	CDD:214630	4/16 (25%)
		KRAB	4..43	CDD:279668	4/15 (27%)
		C2H2 Zn finger	195..215	CDD:275368	3/19 (16%)
		COG5048	217..>553	CDD:227381	108/400 (27%)
		C2H2 Zn finger	223..243	CDD:275368	2/19 (11%)
		zf-H2C2_2	235..260	CDD:290200	8/24 (33%)
		C2H2 Zn finger	251..271	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		zf-H2C2_2	291..316	CDD:290200	7/24 (29%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	6/21 (29%)
		C2H2 Zn finger	363..383	CDD:275368	9/20 (45%)
		zf-H2C2_2	375..400	CDD:290200	12/30 (40%)
		C2H2 Zn finger	391..411	CDD:275368	8/48 (17%)
		zf-H2C2_2	403..426	CDD:290200	8/73 (11%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		zf-H2C2_2	431..454	CDD:290200	8/23 (35%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		zf-H2C2_2	515..538	CDD:290200	10/22 (45%)
		C2H2 Zn finger	531..551	CDD:275368	6/20 (30%)
		C2H2 Zn finger	559..579	CDD:275368	3/16 (19%)
		C2H2 Zn finger	587..607	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100