DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp976

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_017177564.1	Gene:	Zfp976 / 208111	MGIID:	3036263	Length:	673	Species:	Mus musculus

Alignment Length:	414	Identity:	132/414 - (31%)
Similarity:	199/414 - (48%)	Gaps:	49/414 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 YACKFCLR--PQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHAC 249
            |.||.|.:  ||::|     |.:| ..:|...:||.|..|:..:...::..:|..:...||.:.|
Mouse   280 YICKQCNKAYPQQSY-----LRKH-ERTHTGGKPYICNLCDKAYSHQSNLRIHEITHTGEKPYIC 338

  Fly   250 GVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLF 314
            .:|.|.|..:.|||.|...:..|..:.|.||:|.:..:|.|..|.|.|..::.:||..  |::.|
Mouse   339 NLCDKAYSHQSNLRIHERTHTGEKPYICNLCDKAYSHQKYLQIHEKTHTGEKPYKCNQ--CDKGF 401

  Fly   315 ISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAE 379
            ...|:|..||.||   :..|:..|..|||.|..|..||.| .|:|.|||||||..|.:.|.....
Mouse   402 AQLRYLRAHERTH---TQEKTYKCNQCGKAFAQLTYLRVH-ERRHSGEKPYKCNECDKAFLQLKY 462

  Fly   380 KRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQ 444
            .|:|. .||    :..:..||..|.:.|.....|..|                         ||.
Mouse   463 LRLHE-RRH----SGEKPYECNQCGKAFLHPSYLRMH-------------------------ERT 497

  Fly   445 YSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNV 507
            ::|  .:||..|.:.|...|.|..|...|| .::|:.|..|.|.|.::..::.|.:||..|||..
Mouse   498 HTGEKPYQCNECDKAFLHPSYLRMHERRHS-GEKPYECNQCGKAFLQSHYLRMHERTHTGEKPYE 561

  Fly   508 CDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERF 572
            |:.|||||.....|..|...|.. ||.::||.||:|:|:...||:|:|||:|:..|:|:.|.:.|
Mouse   562 CNQCGKAFLHLSYLRMHERRHSG-EKPYECNQCGKAFLYPSYLRMHERTHSGEKPYECNQCGKAF 625

  Fly   573 VTHIKLKTHMQKAHAASQPHSADQ 596
            :....|:.| ::.|:..:|:..:|
Mouse   626 LHSSYLQMH-ERTHSGEKPYECNQ 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	93/311 (30%)
		C2H2 Zn finger	221..241	CDD:275368	3/19 (16%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	10/19 (53%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp976	XP_017177564.1	KRAB	69..109	CDD:366587
		C2H2 Zn finger	174..190	CDD:275368
		C2H2 Zn finger	198..218	CDD:275368
		COG5048	221..595	CDD:227381	113/358 (32%)
		C2H2 Zn finger	226..246	CDD:275368
		C2H2 Zn finger	254..274	CDD:275368
		C2H2 Zn finger	282..302	CDD:275368	8/25 (32%)
		C2H2 Zn finger	310..330	CDD:275368	3/19 (16%)
		C2H2 Zn finger	338..358	CDD:275368	8/19 (42%)
		C2H2 Zn finger	366..386	CDD:275368	8/19 (42%)
		C2H2 Zn finger	394..414	CDD:275368	7/21 (33%)
		C2H2 Zn finger	422..442	CDD:275368	10/20 (50%)
		C2H2 Zn finger	450..470	CDD:275368	5/20 (25%)
		C2H2 Zn finger	478..498	CDD:275368	7/44 (16%)
		C2H2 Zn finger	506..526	CDD:275368	6/19 (32%)
		C2H2 Zn finger	534..554	CDD:275368	5/19 (26%)
		C2H2 Zn finger	562..582	CDD:275368	8/19 (42%)
		C2H2 Zn finger	590..610	CDD:275368	10/19 (53%)
		zf-H2C2_2	602..627	CDD:372612	11/24 (46%)
		C2H2 Zn finger	618..638	CDD:275368	5/20 (25%)
		zf-H2C2_2	630..655	CDD:372612	5/20 (25%)
		C2H2 Zn finger	646..666	CDD:275368	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100