DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp286

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_006532606.3	Gene:	Zfp286 / 192651	MGIID:	2384758	Length:	539	Species:	Mus musculus

Alignment Length:	518	Identity:	134/518 - (25%)
Similarity:	209/518 - (40%)	Gaps:	112/518 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 RLACQEAQLKLSHI-------YDKIDASSL----EDDEIGQEDLEPAEEHQETETTKPTTTVSAE 130
            |..|.|...::..:       |:..|...|    :..:....|:|...|.:|:.:....:...:.
Mouse    94 RRGCSETHCQIPGLPISKPDNYNSEDGKELSKLEKSPKCSDSDMETRPESKESTSVLDFSKEESN 158

  Fly   131 TQPNNTASDPIEIFVDAVDIDEAEE----EEEEEEQQQQYDEEVEE-----PITDESAPPQLTIS 186
            ....|||||.        ||:.|.|    .|..:..:::|..::..     |..::........|
Mouse   159 RLTENTASDS--------DIETALECERWLEHRQRNRERYPRQMSAHRNSLPAQEDGERDVYWKS 215

  Fly   187 YACKFCLR-----PQENYQL--------QQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHL 238
            ::.|..|.     |:.::.:        |:..|......:..::|:.|.||...|   ..|:|.:
Mouse   216 FSQKPLLTTDDRDPKGSWDVHTLGKRLKQKSKLMTKQRPYKEKKPHKCDECGELF---TYRSVLI 277

  Fly   239 KSSHV---EKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPD 300
            :...|   ||.:.|..|||.:..|.||..| ::.|:...|||..|:|.|....||..|.:.|..:
Mouse   278 RHQRVHTGEKPYTCSECGKSFSHRANLTKH-QRTHTRILFECGECKKTFIESSSLEVHQRIHIGE 341

  Fly   301 RQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPY 365
            |.::|  :.|.:.|....||..|:..|:|.   |...|..|.|.|||...|..| .|.|.|||||
Mouse   342 RPYEC--AECGKGFNRSTHLAQHQLIHTGV---KPYECNECDKAFIHSSALIKH-QRTHTGEKPY 400

  Fly   366 KCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPII 430
            ||.:|.:.|:            |..:||..:|                :|
Mouse   401 KCQDCGKAFS------------HCSSLTKHQR----------------VH--------------- 422

  Fly   431 ANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKW 495
                     ..||.|    :|..|.:.|:..:.|.:|..:|: .::|:.|..|.|.|.|:.:...
Mouse   423 ---------TGERPY----ECSECGKTFSQSTHLVQHQRIHT-GEKPYECNECGKTFSRSSNFAK 473

  Fly   496 HIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHT 558
            |.:.|..:||..|..|||||.....|.||:.:| ..||.|:|..||:::....||..||||||
Mouse   474 HQRIHMGKKPYKCGECGKAFVHSSALIQHQRTH-TGEKPFRCTECGKSFKSSPSLIRHQRTHT 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	3/9 (33%)
		COG5048	198..>508	CDD:227381	84/320 (26%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	1/19 (5%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368
Zfp286	XP_006532606.3	zf-H2C2_2	330..355	CDD:372612	8/26 (31%)
		C2H2 Zn finger	346..366	CDD:275368	6/21 (29%)
		COG5048	<370..530	CDD:227381	62/218 (28%)
		C2H2 Zn finger	374..394	CDD:275368	9/20 (45%)
		C2H2 Zn finger	402..422	CDD:275368	7/47 (15%)
		C2H2 Zn finger	430..450	CDD:275368	5/19 (26%)
		C2H2 Zn finger	458..478	CDD:275368	6/19 (32%)
		C2H2 Zn finger	486..506	CDD:275368	9/19 (47%)
		C2H2 Zn finger	514..534	CDD:275368	8/19 (42%)
		C2H2 Zn finger	239..255	CDD:275368	2/15 (13%)
		C2H2 Zn finger	263..283	CDD:275368	6/22 (27%)
		zf-H2C2_2	276..300	CDD:372612	7/23 (30%)
		zf-C2H2	289..311	CDD:333835	8/22 (36%)
		C2H2 Zn finger	291..311	CDD:275368	8/20 (40%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100