DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Giot1

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_598247.1	Gene:	Giot1 / 171090	RGDID:	620184	Length:	654	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	151/556 - (27%)
Similarity:	235/556 - (42%)	Gaps:	115/556 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 PQKICSDCFTKFCSIN-----AFRLA-CQEAQLKLSHIYDKIDASSLEDDE-----IGQEDLEPA 112
            |..:|      .||:|     .::.. |.:|            .|||:..|     .|.:..||.
  Rat   141 PSSLC------ICSVNHTVRKCYKCTQCSKA------------LSSLQRHEKTHLGRGIDKCEPC 187

  Fly   113 EEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDE 177
            ..|.        |...|..:.||                        ||...:|:      :.|:
  Rat   188 TNHH--------TYFQAHKRTNN------------------------EEDTYEYN------LCDK 214

  Fly   178 SAPPQLTISYACKFCLRPQENYQLQQ------LLLEHINASHDPEQPYNCPECEARFQDAASRTV 236
            :.....::.......:.|.:.||.::      .|.||  .:|..|:||.|.:|...|....:..:
  Rat   215 AFRSDSSLHQRPHLEVAPYKYYQYEKDFAHHSCLQEH--RTHTGEKPYKCNQCGKAFASRHNLKM 277

  Fly   237 HLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHS-ETDFECALCEKRFYTRKSLNYHMKWHNPD 300
            |.:....||.:.|..|||.:....|||.| ||.|: |..:||:.|.|.|..|..|..|.:.|..:
  Rat   278 HERIHTGEKPYTCNQCGKAFTLYTNLRKH-EKIHTGEKPYECSQCGKAFARRNELQVHERIHTGE 341

  Fly   301 RQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPY 365
            :.::|  |.|.:.|.|:.:|..||.||:|   .|...|..|||.|...:.|:.| .|.|.|||||
  Rat   342 KPYEC--SQCGKAFASRSNLQTHERTHTG---EKPYLCNQCGKAFAWRRLLQIH-ERIHTGEKPY 400

  Fly   366 KCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPII 430
            .|..|.:.|..:..     |..|::..|..:...|..|.:.|:       |:::.|
  Rat   401 ACNQCGKAFTHFPS-----LHNHKKIHTGEKPYTCNECGKAFA-------HLTSFH--------- 444

  Fly   431 ANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKW 495
             |:|::  ...|:.|.    |..|.:.|:.:|.|:.|...| :.::||.|..|.|.|.....::.
  Rat   445 -NHKKI--HTGEKPYG----CKQCGKAFSFRSNLQIHETAH-KGEKPHECNQCGKAFAHIVYLQR 501

  Fly   496 HIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGK 560
            |.::| .:||..|:.|||.|.....|..|..|| ..||.::||.||:.:.:..:|:.|:|||||:
  Rat   502 HERSH-GDKPYECNQCGKGFTHFGRLKNHLKSH-TGEKPYECNQCGKVFAYRNNLQKHERTHTGE 564

  Fly   561 TYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            ..|.||.|.:.|.:...|:.| :|.|...:|:..:|
  Rat   565 KPYVCDQCGKAFASRCNLQKH-EKIHTQEKPYVCNQ 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	7/33 (21%)
		COG5048	198..>508	CDD:227381	94/316 (30%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	9/19 (47%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	8/21 (38%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Giot1	NP_598247.1	KRAB	4..>46	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	131..151	CDD:275368	4/15 (27%)
		C2H2 Zn finger	159..176	CDD:275368	6/28 (21%)
		C2H2 Zn finger	182..201	CDD:275368	5/26 (19%)
		COG5048	258..654	CDD:227381	120/381 (31%)
		C2H2 Zn finger	262..282	CDD:275368	4/19 (21%)
		zf-H2C2_2	274..298	CDD:290200	7/23 (30%)
		C2H2 Zn finger	290..310	CDD:275368	10/20 (50%)
		zf-H2C2_2	302..327	CDD:290200	13/25 (52%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
		zf-H2C2_2	330..355	CDD:290200	7/26 (27%)
		C2H2 Zn finger	346..366	CDD:275368	8/21 (38%)
		zf-H2C2_2	358..382	CDD:290200	11/26 (42%)
		C2H2 Zn finger	374..394	CDD:275368	8/20 (40%)
		zf-H2C2_2	387..411	CDD:290200	12/24 (50%)
		C2H2 Zn finger	402..422	CDD:275368	5/24 (21%)
		zf-H2C2_2	417..439	CDD:290200	5/28 (18%)
		C2H2 Zn finger	430..450	CDD:275368	7/38 (18%)
		C2H2 Zn finger	458..478	CDD:275368	6/19 (32%)
		C2H2 Zn finger	486..506	CDD:275368	5/19 (26%)
		zf-C2HE	<508..533	CDD:292895	9/24 (38%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	526..550	CDD:290200	10/24 (42%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		zf-H2C2_2	553..578	CDD:290200	12/24 (50%)
		C2H2 Zn finger	569..589	CDD:275368	7/20 (35%)
		zf-H2C2_2	581..606	CDD:290200	6/20 (30%)
		C2H2 Zn finger	597..617	CDD:275368	1/3 (33%)
		C2H2 Zn finger	625..645	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100