DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp87

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_573491.2	Gene:	Zfp87 / 170763	MGIID:	107768	Length:	540	Species:	Mus musculus

Alignment Length:	475	Identity:	132/475 - (27%)
Similarity:	207/475 - (43%)	Gaps:	70/475 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 QQQQYDEEVEEPITDESAP---PQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPE 223
            :|:|....|:.|......|   |     |.|:   ...:.:....|||:. ...|..|:||.|.|
Mouse    58 EQRQEPSVVKRPAAATVHPGGKP-----YKCQ---EFDKTFDWNSLLLQR-QRVHPVEKPYKCEE 113

  Fly   224 CEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRK 288
            |...|...::.::|.:....||.:.|..|||.:..|..|..|.:.:..:..::|..|.|.||...
Mouse   114 CGKVFSAHSALSIHQRIHTGEKPYKCEECGKAFSTRSALYIHKKIHSGDKPYKCEECAKAFYFPS 178

  Fly   289 SLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRW 353
            .|..|.:.|:.:...||..  |.:.|.....|..|:..||..:..:   |..|||.|.:..||:.
Mouse   179 LLKQHQRTHSAENLCKCEE--CGKAFYLPSFLKQHQRIHSAENPYR---CEECGKAFSYPSTLKQ 238

  Fly   354 HIYRQHGGEKPYKCANCTEVFAS----YAEKRIHMLER------------HRENL-------TAI 395
            | .|.|.|||||:|..|.:.|..    :..:|||..|:            :|.||       :.:
Mouse   239 H-QRIHSGEKPYRCEECGKAFRRSTYFHQHQRIHTGEKPYQCEECGKTFYYRSNLKGHQIIHSGV 302

  Fly   396 ERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPI-----------IANNKRVLQQK----RERQY 445
            :..:|.:|...|.:..||..|      ||..|.:           .:.:..:::.|    ||:.|
Mouse   303 KPYKCEVCGSMFRTSSDLSKH------QRIHAEVKLYSCEECGKAFSTHSYLIRHKLGHSREKPY 361

  Fly   446 SGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDV 510
                :|..|.:.|...|.|:.|..:||.. :|:.|..|...|:...::..|.:.|.:.|...|:.
Mouse   362 ----KCEECGKTFCYPSILKEHQRIHSGV-KPYNCEICGSMFRTRSELSKHQRIHAEVKLYNCEE 421

  Fly   511 CGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTH 575
            |||||:....|.:|||.|.. ||.:||..||::|.:...|:.|||.|: :..||||:|.:.|.|.
Mouse   422 CGKAFSTHSYLMRHRLGHSG-EKPYKCEECGKSYSYPSLLKEHQRIHS-QNPYKCDVCGKVFCTR 484

  Fly   576 IKLKTHMQKAHAASQPHSAD 595
            .....| |:.|...:|:..:
Mouse   485 SGRSKH-QRIHTGEKPYKCE 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	90/347 (26%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	4/19 (21%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Zfp87	NP_573491.2	KRAB	5..65	CDD:214630	2/6 (33%)
		KRAB	5..44	CDD:279668
		C2H2 Zn finger	83..103	CDD:275368	4/23 (17%)
		COG5048	107..472	CDD:227381	108/383 (28%)
		C2H2 Zn finger	111..131	CDD:275368	5/19 (26%)
		zf-H2C2_2	123..148	CDD:290200	7/24 (29%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		C2H2 Zn finger	195..215	CDD:275368	5/21 (24%)
		zf-H2C2_2	208..232	CDD:290200	9/26 (35%)
		C2H2 Zn finger	223..243	CDD:275368	9/20 (45%)
		zf-H2C2_2	236..260	CDD:290200	12/24 (50%)
		C2H2 Zn finger	251..271	CDD:275368	4/19 (21%)
		zf-H2C2_2	266..288	CDD:290200	4/21 (19%)
		C2H2 Zn finger	279..299	CDD:275368	3/19 (16%)
		C2H2 Zn finger	307..327	CDD:275368	8/25 (32%)
		C2H2 Zn finger	335..355	CDD:275368	1/19 (5%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		C2H2 Zn finger	419..439	CDD:275368	10/19 (53%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..494	CDD:275368	7/20 (35%)
		zf-H2C2_2	489..511	CDD:290200	4/16 (25%)
		C2H2 Zn finger	502..522	CDD:275368	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100