DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF467

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_011514159.1	Gene:	ZNF467 / 168544	HGNCID:	23154	Length:	809	Species:	Homo sapiens

Alignment Length:	581	Identity:	150/581 - (25%)
Similarity:	233/581 - (40%)	Gaps:	101/581 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 DKIDASSLEDDEIGQEDLEPAEEHQE-TETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEE 155
            :.::|.|.....:||.::.|..|.:| :...:...:.|.|.:.....|.. |..:..|.:::.::
Human   254 ETLEALSSLGFSVGQPEMAPQSEPREGSHNAQEQMSSSREERALGVCSGE-EWMIRKVKVEDEDQ 317

  Fly   156 EEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYN 220
            |.|||.:..|:...:..|.   .||....::.|.|  |.|.....|..|.|......  ||:||.
Human   318 EAEEEVEWPQHLSLLPSPF---PAPDLGHLAAAYK--LEPGAPGALSGLALSGWGPM--PEKPYG 375

  Fly   221 CPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFY 285
            |.|||.||:|..:..:|.:....|...||..||:.:..|.::..|...:..|..|.|:.|:|||.
Human   376 CGECERRFRDQLTLRLHQRLHRGEGPCACPDCGRSFTQRAHMLLHQRSHRGERPFPCSECDKRFS 440

  Fly   286 TRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKT 350
            .:..|..|::.|..:|.:.|  :.|.:.|..:.||..|:.||:|   .:...|..|.|.| ..||
Human   441 KKAHLTRHLRTHTGERPYPC--AECGKRFSQKIHLGSHQKTHTG---ERPFPCTECEKRF-RKKT 499

  Fly   351 LRWHIYRQ---HGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTA------------------ 394
               |:.|.   |.||:||:||.|..   |:..|: |::...|.:.||
Human   500 ---HLIRHQRIHTGERPYQCAQCAR---SFTHKQ-HLVRHQRVHQTAGPARPSPDSSASPHSTAP 557

  Fly   395 --------IERSECMLCRQPFSSEPDLIHHM------------------------SAEHL-QRPG 426
                    .:...|..|...|..:.:|..|.                        :|:.| ..||
Human   558 SPTPSFPGPKPFACSDCGLSFGWKKNLATHQCLHRSEGRPFGCDECALGATVDAPAAKPLASAPG 622

  Fly   427 APIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQ 491
            .|........:..:|.......|.|..|.:.|:....|.||..||: .:||.||..|.:||....
Human   623 GPGCGPGSDPVVPQRAPSGERSFFCPDCGRGFSHGQHLARHPRVHT-GERPFACTQCDRRFGSRP 686

  Fly   492 DMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRT 556
            ::..|.:.|...:|..|..||:.|:.|..|.:|:..| ...:...|.||.|::..:.:|..||..
Human   687 NLVAHSRAHSGARPFACAQCGRRFSRKSHLGRHQAVH-TGSRPHACAVCARSFSSKTNLVRHQAI 750

  Fly   557 HTGKTYYKCDLCQERFVTHIKLKTHM--------QKAHAA-----------SQPHSADQPL 598
            |||...:.|..|.:.|    ..|||:        :.||||           :.|..|..||
Human   751 HTGSRPFSCPQCGKSF----SRKTHLVRHQLIHGEAAHAAPDAALAAPAWSAPPEVAPPPL 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	94/363 (26%)
		C2H2 Zn finger	221..241	CDD:275368	8/19 (42%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/23 (35%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	5/43 (12%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF467	XP_011514159.1	C2H2 Zn finger	376..396	CDD:275368	8/19 (42%)
		zf-H2C2_2	389..413	CDD:290200	6/23 (26%)
		COG5048	404..779	CDD:227381	101/393 (26%)
		C2H2 Zn finger	404..424	CDD:275368	5/19 (26%)
		zf-H2C2_2	416..440	CDD:290200	7/23 (30%)
		zf-C2H2	430..452	CDD:278523	8/21 (38%)
		C2H2 Zn finger	432..452	CDD:275368	7/19 (37%)
		zf-H2C2_2	444..469	CDD:290200	7/26 (27%)
		C2H2 Zn finger	460..480	CDD:275368	6/21 (29%)
		zf-H2C2_2	472..495	CDD:290200	9/25 (36%)
		C2H2 Zn finger	488..508	CDD:275368	8/23 (35%)
		zf-H2C2_2	500..525	CDD:290200	11/27 (41%)
		C2H2 Zn finger	516..536	CDD:275368	7/23 (30%)
		C2H2 Zn finger	571..591	CDD:275368	5/19 (26%)
		C2H2 Zn finger	647..667	CDD:275368	6/19 (32%)
		zf-H2C2_2	659..682	CDD:290200	10/23 (43%)
		C2H2 Zn finger	675..695	CDD:275368	5/19 (26%)
		C2H2 Zn finger	703..723	CDD:275368	7/19 (37%)
		C2H2 Zn finger	731..751	CDD:275368	7/19 (37%)
		zf-H2C2_2	743..768	CDD:290200	9/28 (32%)
		C2H2 Zn finger	759..779	CDD:275368	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100