DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF540

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001165696.1	Gene:	ZNF540 / 163255	HGNCID:	25331	Length:	660	Species:	Homo sapiens

Alignment Length:	481	Identity:	132/481 - (27%)
Similarity:	206/481 - (42%)	Gaps:	87/481 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 EEEEEEEQQQQYDEE-------VEEPITDESAPPQLTISYAC----KFCLRPQENYQLQQLLLEH 208
            :.:.|.|.||...|.       |.:.::.:...|..|::...    |.|         ...|::|
Human   123 QNKSEFEGQQGLKERSISQKKIVSKKMSTDRKRPSFTLNQRIHNSEKSC---------DSHLVQH 178

  Fly   209 INASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHS-E 272
              ...|.:..::|.||.:.|.:....|:|.|....||...|..|||.:...:.|..| :::|: |
Human   179 --GKIDSDVKHDCKECGSTFNNVYQLTLHQKIHTGEKSCKCEKCGKVFSHSYQLTLH-QRFHTGE 240

  Fly   273 TDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEH 337
            ..:||..|.|.|.....||.|.|.|...:.:.|:.  |::.|.|:..|..|:..|:|   :||..
Human   241 KPYECQECGKTFTLYPQLNRHQKIHTGKKPYMCKK--CDKGFFSRLELTQHKRIHTG---KKSYE 300

  Fly   338 CGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECML 402
            |..|||.|..:...:.| .|.|.|:|||:|..|.:.|:...:     |.||::..|.::..||..
Human   301 CKECGKVFQLIFYFKEH-ERIHTGKKPYECKECGKAFSVCGQ-----LTRHQKIHTGVKPYECKE 359

  Fly   403 CRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERH 467
            |.:.|.....|..|......::|                       ::|..|.:.||::..|.||
Human   360 CGKTFRLSFYLTEHRRTHAGKKP-----------------------YECKECGKSFNVRGQLNRH 401

  Fly   468 AAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLE 532
            ..:|: ..:|.||..|.|.|..:.|::.|.:.|..|||..|..|||||.|:.|||:|:..|..::
Human   402 KTIHT-GIKPFACKVCEKAFSYSGDLRVHSRIHTGEKPYECKECGKAFMLRSVLTEHQRLHTGVK 465

  Fly   533 ---------------------------KNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQE 570
                                       |.:||..||:.:.|...|..|||.|||:..|||..|.:
Human   466 PYECKECGKTFRVRSQISLHKKIHTDVKPYKCVRCGKTFRFGFYLTEHQRIHTGEKPYKCKECGK 530

  Fly   571 RFVTHIKLKTHMQKAHAASQPHSADQ 596
            .|:....||.|: |.|:..:|:...:
Human   531 AFIRRGNLKEHL-KIHSGLKPYDCKE 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	86/310 (28%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	11/19 (58%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF540	NP_001165696.1	KRAB	6..66	CDD:214630
		C2H2 Zn finger	189..209	CDD:275368	7/19 (37%)
		C2H2 Zn finger	217..237	CDD:275368	6/20 (30%)
		COG5048	241..620	CDD:227381	102/351 (29%)
		C2H2 Zn finger	245..265	CDD:275368	8/19 (42%)
		C2H2 Zn finger	273..293	CDD:275368	6/21 (29%)
		C2H2 Zn finger	301..321	CDD:275368	7/20 (35%)
		C2H2 Zn finger	329..349	CDD:275368	6/24 (25%)
		C2H2 Zn finger	357..377	CDD:275368	5/19 (26%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		C2H2 Zn finger	413..433	CDD:275368	6/19 (32%)
		C2H2 Zn finger	441..461	CDD:275368	11/19 (58%)
		C2H2 Zn finger	469..489	CDD:275368	0/19 (0%)
		C2H2 Zn finger	497..517	CDD:275368	8/19 (42%)
		C2H2 Zn finger	525..545	CDD:275368	7/20 (35%)
		C2H2 Zn finger	553..573	CDD:275368	0/3 (0%)
		C2H2 Zn finger	581..601	CDD:275368
		C2H2 Zn finger	609..629	CDD:275368
		zf-H2C2_2	621..646	CDD:316026
		C2H2 Zn finger	637..657	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100