DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF497

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001193938.1	Gene:	ZNF497 / 162968	HGNCID:	23714	Length:	498	Species:	Homo sapiens

Alignment Length:	425	Identity:	124/425 - (29%)
Similarity:	185/425 - (43%)	Gaps:	39/425 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 EPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTV 236
            ||......|..|.....|: |....:.:.....||:| ...|..|:||.||||...|..:::.:.
Human    89 EPADRALRPSPLPEEPGCR-CGECGKAFSQGSYLLQH-RRVHTGEKPYTCPECGKAFAWSSNLSQ 151

  Fly   237 HLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDR 301
            |.:....||.:||..|||.:.....|.||.|.:.....|.|..|.|.|....:|..|.:.|..::
Human   152 HQRIHSGEKPYACRECGKAFRAHSQLIHHQETHSGLKPFRCPDCGKSFGRSTTLVQHRRTHTGEK 216

  Fly   302 QFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYK 366
            .::|..  |.:.|....:.:.|...|:|.   :...|..|||.|.....|..|: :.|.|.:|:.
Human   217 PYECPE--CGKAFSWNSNFLEHRRVHTGA---RPHACRDCGKAFSQSSNLAEHL-KIHAGARPHA 275

  Fly   367 CANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIA 431
            |.:|.:.|.     |:..|.:||...::.:...|..|.:.|.....|:.|......:||
Human   276 CPDCGKAFV-----RVAGLRQHRRTHSSEKPFPCAECGKAFRESSQLLQHQRTHTGERP------ 329

  Fly   432 NNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWH 496
                             |:|..|.|.|.|.|.|..|..||: .::||||..|.|.|.:..::..|
Human   330 -----------------FECAECGQAFVMGSYLAEHRRVHT-GEKPHACAQCGKAFSQRSNLLSH 376

  Fly   497 IKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKT 561
            .:||...||..|..|||||.....|..||||| ..|:.|.|..||:|:.....||.|||.|:|:.
Human   377 RRTHSGAKPFACADCGKAFRGSSGLAHHRLSH-TGERPFACAECGKAFRGSSELRQHQRLHSGER 440

  Fly   562 YYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            .:.|..|.:.||...:|.:| ::.|...:|::..:
Human   441 PFVCAHCSKAFVRKSELLSH-RRTHTGERPYACGE 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	85/309 (28%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	4/21 (19%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF497	NP_001193938.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..104		4/14 (29%)
		COG5048	107..492	CDD:227381	119/407 (29%)
		C2H2 Zn finger	108..128	CDD:275368	4/20 (20%)
		zf-H2C2_2	120..144	CDD:290200	11/24 (46%)
		C2H2 Zn finger	136..156	CDD:275368	6/19 (32%)
		zf-H2C2_2	148..171	CDD:290200	8/22 (36%)
		C2H2 Zn finger	164..184	CDD:275368	8/19 (42%)
		zf-C2H2	190..212	CDD:278523	7/21 (33%)
		C2H2 Zn finger	192..212	CDD:275368	6/19 (32%)
		zf-H2C2_2	205..228	CDD:290200	5/24 (21%)
		C2H2 Zn finger	220..240	CDD:275368	4/21 (19%)
		C2H2 Zn finger	248..268	CDD:275368	7/20 (35%)
		C2H2 Zn finger	276..296	CDD:275368	7/24 (29%)
		zf-H2C2_2	289..311	CDD:290200	5/21 (24%)
		C2H2 Zn finger	304..324	CDD:275368	5/19 (26%)
		zf-H2C2_2	317..340	CDD:290200	8/45 (18%)
		C2H2 Zn finger	332..352	CDD:275368	8/19 (42%)
		zf-H2C2_2	344..369	CDD:290200	11/25 (44%)
		C2H2 Zn finger	360..380	CDD:275368	5/19 (26%)
		C2H2 Zn finger	388..408	CDD:275368	10/19 (53%)
		C2H2 Zn finger	416..436	CDD:275368	9/19 (47%)
		zf-H2C2_2	428..453	CDD:290200	10/24 (42%)
		C2H2 Zn finger	444..464	CDD:275368	6/20 (30%)
		zf-H2C2_2	456..481	CDD:290200	4/20 (20%)
		C2H2 Zn finger	472..492	CDD:275368	0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910