DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF320

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001338702.1	Gene:	ZNF320 / 162967	HGNCID:	13842	Length:	509	Species:	Homo sapiens

Alignment Length:	482	Identity:	131/482 - (27%)
Similarity:	199/482 - (41%)	Gaps:	76/482 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 TVSAETQPN------NTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDE--EVEEPITDESAPPQ 182
            |:|:..|.|      .|........:.|....|.|::..:...|.|.||  :.|.|:|:......
Human    57 TLSSTGQGNTEVIHTGTLQRQASYHIGAFCSQEIEKDIHDFVFQWQEDETNDHEAPMTEIKKLTS 121

  Fly   183 LTISYACKFCLRPQENYQLQQLLLEHINAS---HDPEQPYNCPECEARFQDAASRTVHLKSSHVE 244
            .|..|..:.........||:.....|:...   |..|:||.|.||                   |
Human   122 STDRYDQRHAGNKPIKGQLESRFHLHLRRHRRIHTGEKPYKCEEC-------------------E 167

  Fly   245 KQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSG 309
            |..:|    |.:.:.|.:.|..||     .::|.:|:|.|.....|..|.:.|..|:.:.|..
Human   168 KVFSC----KSHLEIHRIIHTGEK-----PYKCKVCDKAFKHDSHLAKHTRIHRGDKHYTCNE-- 221

  Fly   310 CERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVF 374
            |.::|..:..|.||..:|:|   .|...|..|||||.....|.:| :|.|.|||||||..|.:.|
Human   222 CGKVFDQKATLACHHRSHTG---EKPYKCNECGKTFSQTSHLVYH-HRLHTGEKPYKCNECGKTF 282

  Fly   375 ASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQ 439
            |     |..:|..|:...||.:..:|..|.:.|.....|..|......::|
Human   283 A-----RNSVLVIHKAVHTAEKPYKCNECGKVFKQRATLAGHRRVHTGEKP-------------- 328

  Fly   440 KRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEK 504
                     ::|..|.:.|:.||.||||..:|: .::|:.|..|.|.|:....:..|.:.|..|:
Human   329 ---------YRCEECDKVFSRKSHLERHRRIHT-GEKPYKCKVCDKAFRSDSRLAEHQRVHTGER 383

  Fly   505 PNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQ 569
            |..|:.|||.|:.|..|..|:..| ..||.::|..|.:.|:.:..|..|:|.|||:..:||..|.
Human   384 PYTCNECGKVFSTKAYLACHQKLH-TGEKLYECEECDKVYIRKSHLERHRRIHTGEKPHKCGDCG 447

  Fly   570 ERFVTHIKLKTHMQKAHAASQPHSADQ 596
            :.|.:...|..| |:.|...:.:...|
Human   448 KAFNSPSHLIRH-QRIHTGQKSYKCHQ 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	85/312 (27%)
		C2H2 Zn finger	221..241	CDD:275368	3/19 (16%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	9/19 (47%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF320	NP_001338702.1	KRAB	7..48	CDD:396083
		SFP1	<25..216	CDD:227516	43/186 (23%)
		COG5048	147..483	CDD:227381	112/392 (29%)
		C2H2 Zn finger	163..183	CDD:275368	8/42 (19%)
		C2H2 Zn finger	191..211	CDD:275368	6/19 (32%)
		C2H2 Zn finger	219..239	CDD:275368	6/21 (29%)
		C2H2 Zn finger	247..267	CDD:275368	9/20 (45%)
		C2H2 Zn finger	275..295	CDD:275368	7/24 (29%)
		C2H2 Zn finger	303..323	CDD:275368	5/19 (26%)
		C2H2 Zn finger	331..351	CDD:275368	9/19 (47%)
		C2H2 Zn finger	359..379	CDD:275368	5/19 (26%)
		C2H2 Zn finger	387..407	CDD:275368	8/19 (42%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		C2H2 Zn finger	443..463	CDD:275368	6/20 (30%)
		C2H2 Zn finger	471..490	CDD:275368	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100