DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF782

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001001662.1	Gene:	ZNF782 / 158431	HGNCID:	33110	Length:	699	Species:	Homo sapiens

Alignment Length:	407	Identity:	131/407 - (32%)
Similarity:	192/407 - (47%)	Gaps:	60/407 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 TISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHL---KSSHV-E 244
            |.||        |..:.:.|.:  ||.|     :||...||    ..:.|...||   :.||. |
Human   346 TFSY--------QSTFSVHQKV--HIRA-----KPYEYNEC----GKSCSMNSHLIWPQKSHTGE 391

  Fly   245 KQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSG 309
            |.:.|..|||.:.::..||.|...:..|..::|..|:|.|..:..|..|.:.|..::.|:|..
Human   392 KPYECPECGKAFSEKSRLRKHQRTHTGEKPYKCDGCDKAFSAKSGLRIHQRTHTGEKPFECHE-- 454

  Fly   310 CERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVF 374
            |.:.|..:..|:.|:.||:|   .|...|..|||:|.|:..||.| .|.|.||:||||..|.:.|
Human   455 CGKSFNYKSILIVHQRTHTG---EKPFECNECGKSFSHMSGLRNH-RRTHTGERPYKCDECGKAF 515

  Fly   375 ASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQ 439
                 |....|.:|....|..:..:|..|.:.|..:..|..|......::|
Human   516 -----KLKSGLRKHHRTHTGEKPYKCNQCGKAFGQKSQLRGHHRIHTGEKP-------------- 561

  Fly   440 KRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEK 504
                     ::|..|.:.|:.||.|..|...|: .::|:.|..|.|.|::..:::.|.:||..||
Human   562 ---------YKCNHCGEAFSQKSNLRVHHRTHT-GEKPYQCEECGKTFRQKSNLRGHQRTHTGEK 616

  Fly   505 PNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQ 569
            |..|:.|||||:.|.||.:|:.:| ..||.:.||.||.|:..:.:||:|||||||:..||||.|.
Human   617 PYECNECGKAFSEKSVLRKHQRTH-TGEKPYNCNQCGEAFSQKSNLRVHQRTHTGEKPYKCDKCG 680

  Fly   570 ERFVTHIKLKTHMQKAH 586
            ..|.....|:.| ||||
Human   681 RTFSQKSSLREH-QKAH 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	88/313 (28%)
		C2H2 Zn finger	221..241	CDD:275368	5/22 (23%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	10/19 (53%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF782	NP_001001662.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..95
		C2H2 Zn finger	291..307	CDD:275368
		C2H2 Zn finger	314..332	CDD:275368
		C2H2 Zn finger	343..360	CDD:275368	5/23 (22%)
		C2H2 Zn finger	369..388	CDD:275368	5/22 (23%)
		COG5048	392..697	CDD:227381	113/342 (33%)
		C2H2 Zn finger	396..416	CDD:275368	7/19 (37%)
		zf-H2C2_2	409..432	CDD:290200	7/22 (32%)
		C2H2 Zn finger	424..444	CDD:275368	6/19 (32%)
		zf-H2C2_2	437..461	CDD:290200	7/25 (28%)
		C2H2 Zn finger	452..472	CDD:275368	5/21 (24%)
		zf-H2C2_2	465..489	CDD:290200	11/26 (42%)
		C2H2 Zn finger	480..500	CDD:275368	10/20 (50%)
		zf-H2C2_2	493..516	CDD:290200	13/28 (46%)
		C2H2 Zn finger	508..528	CDD:275368	6/24 (25%)
		zf-H2C2_2	521..543	CDD:290200	5/21 (24%)
		C2H2 Zn finger	536..556	CDD:275368	5/19 (26%)
		zf-H2C2_2	549..573	CDD:290200	6/46 (13%)
		C2H2 Zn finger	564..584	CDD:275368	7/19 (37%)
		zf-H2C2_2	576..601	CDD:290200	8/25 (32%)
		C2H2 Zn finger	592..612	CDD:275368	5/19 (26%)
		zf-H2C2_2	604..628	CDD:290200	11/23 (48%)
		C2H2 Zn finger	620..640	CDD:275368	10/19 (53%)
		zf-H2C2_2	633..657	CDD:290200	10/24 (42%)
		C2H2 Zn finger	648..668	CDD:275368	10/19 (53%)
		zf-H2C2_2	660..685	CDD:290200	15/24 (63%)
		C2H2 Zn finger	676..696	CDD:275368	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910