DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF483

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_597721.2	Gene:	ZNF483 / 158399	HGNCID:	23384	Length:	744	Species:	Homo sapiens

Alignment Length:	393	Identity:	103/393 - (26%)
Similarity:	159/393 - (40%)	Gaps:	68/393 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 CKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCG 253
            |:.|.:.    ..|:..|.....:...|:.:.|.:|...|..:||.|.|.:....||.:.|..||
Human   413 CEKCRKD----SCQEAALNKDEGNESGEKTHKCSKCGKAFGYSASLTKHRRIHTGEKPYMCNECG 473

  Fly   254 KKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQR 318
            |.:.|..:|..|...:..|..|:|..|.|.|.....|..|.:.|..::.:||:  .|.|.|....
Human   474 KAFSDSSSLTPHHRTHSGEKPFKCDDCGKGFTLSAHLIKHQRIHTGEKPYKCK--DCGRPFSDSS 536

  Fly   319 HLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIH 383
            .|:.|:..|:|   .|...|..|||:|.|..:|..| .|.|.|||||||..|.:.|     ::..
Human   537 SLIQHQRIHTG---EKPYTCSNCGKSFSHSSSLSKH-QRIHTGEKPYKCGECGKAF-----RQNS 592

  Fly   384 MLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGL 448
            .|.||:...|..:...|..|...||....:|:|......::|
Human   593 CLTRHQRIHTGEKPYLCNDCGMTFSHFTSVIYHQRLHSGEKP----------------------- 634

  Fly   449 FQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGK 513
            ::|..|.:.|...|.|.||..:|:.. :|:.|..|.|.|.::..:..|.:.|..|||..|:.||.
Human   635 YKCNQCEKAFPTHSLLSRHQRIHTGV-KPYKCKECGKSFSQSSSLNEHHRIHTGEKPYECNYCGA 698

  Fly   514 AFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKL 578
            .|:...:|.:                             |.:.|||:..|:|:.|::.|.::..|
Human   699 TFSRSSILVE-----------------------------HLKIHTGRREYECNECEKTFKSNSGL 734

  Fly   579 KTH 581
            ..|
Human   735 IRH 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	86/309 (28%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	5/19 (26%)
		C2H2 Zn finger	537..557	CDD:275368	1/19 (5%)
		C2H2 Zn finger	565..582	CDD:275368	5/17 (29%)
ZNF483	NP_597721.2	SCAN	49..152	CDD:128708
		SCAN	49..136	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..156
		KRAB	171..229	CDD:214630
		KRAB	171..209	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..308
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..385
		C2H2 Zn finger	361..384	CDD:275368
		C2H2 Zn finger	413..433	CDD:275368	4/23 (17%)
		COG5048	437..>735	CDD:227381	96/361 (27%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		zf-H2C2_2	453..477	CDD:290200	9/23 (39%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		zf-H2C2_2	485..505	CDD:290200	6/19 (32%)
		C2H2 Zn finger	497..517	CDD:275368	6/19 (32%)
		zf-H2C2_2	509..533	CDD:290200	7/25 (28%)
		zf-C2H2	523..545	CDD:278523	7/23 (30%)
		C2H2 Zn finger	525..545	CDD:275368	6/21 (29%)
		zf-C2H2	579..601	CDD:278523	8/26 (31%)
		C2H2 Zn finger	581..601	CDD:275368	6/24 (25%)
		zf-H2C2_2	594..618	CDD:290200	7/23 (30%)
		C2H2 Zn finger	609..629	CDD:275368	6/19 (32%)
		zf-H2C2_2	625..644	CDD:290200	4/41 (10%)
		C2H2 Zn finger	637..657	CDD:275368	7/19 (37%)
		zf-H2C2_2	650..674	CDD:290200	9/24 (38%)
		C2H2 Zn finger	665..685	CDD:275368	5/19 (26%)
		zf-H2C2_2	677..702	CDD:290200	9/24 (38%)
		C2H2 Zn finger	693..713	CDD:275368	6/48 (13%)
		zf-H2C2_2	706..730	CDD:290200	9/52 (17%)
		C2H2 Zn finger	721..741	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100