DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF569

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_006723109.1	Gene:	ZNF569 / 148266	HGNCID:	24737	Length:	710	Species:	Homo sapiens

Alignment Length:	487	Identity:	139/487 - (28%)
Similarity:	207/487 - (42%)	Gaps:	73/487 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 EVEEPITD--ESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDA 231
            |..||:..  .|:...:...:.|..|   .:.:.....|:.|:.. |..|:||.|..|...|...
Human   190 EYNEPVKSYGNSSSHFVITPFKCNHC---GKGFNQTLDLIRHLRI-HTGEKPYECSNCRKAFSHK 250

  Fly   232 ASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKW 296
            .....|.|....|:.:.|..|||.:....||..|...:..|..:.|..|||.|..:.:|..|.|.
Human   251 EKLIKHYKIHSREQSYKCNECGKAFIKMSNLIRHQRIHTGEKPYACKECEKSFSQKSNLIDHEKI 315

  Fly   297 HNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGG 361
            |..::.::|..  |.:.|..::.|:.|:..|:|   .|...|..|||.|..:.:|..|: |.|.|
Human   316 HTGEKPYECNE--CGKAFSQKQSLIAHQKVHTG---EKPYACNECGKAFPRIASLALHM-RSHTG 374

  Fly   362 EKPYKCANCTEVFASYA----EKRIHMLER-------------------HRENLTAIERSECMLC 403
            ||||||..|.:.|:.::    ..|||..|:                   |..:.|..:..||..|
Human   375 EKPYKCDKCGKAFSQFSMLIIHVRIHTGEKPYECNECGKAFSQSSALTVHMRSHTGEKPYECKEC 439

  Fly   404 RQPFSSEPDLIHHMSAEHLQRP------GAPIIANNKRVLQQK---RERQYSGLFQCGSCSQRFN 459
            |:.||.:.:.|.|......::|      |...|..:..|..|:   .|:.|.    |..|.:.|:
Human   440 RKAFSHKKNFITHQKIHTREKPYECNECGKAFIQMSNLVRHQRIHTGEKPYI----CKECGKAFS 500

  Fly   460 MKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQH 524
            .||.|..|..:|| .::|:.|..|.|.|.:.|:...|.|.|..|||..|:.|||||:....||.|
Human   501 QKSNLIAHEKIHS-GEKPYECNECGKAFSQKQNFITHQKVHTGEKPYDCNECGKAFSQIASLTLH 564

  Fly   525 RLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAAS 589
            ..|| ..||.::|:.||:|:.....|.||.|:|||:..|.|:.|.:.|.....|..|| :.|...
Human   565 LRSH-TGEKPYECDKCGKAFSQCSLLNLHMRSHTGEKPYVCNECGKAFSQRTSLIVHM-RGHTGE 627

  Fly   590 QP----------------------HSADQPLD 599
            :|                      |:.::|.|
Human   628 KPYECNKCGKAFSQSSSLTIHIRGHTGEKPFD 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	97/341 (28%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF569	XP_006723109.1	KRAB	32..86	CDD:214630
		COG5048	<200..368	CDD:227381	46/176 (26%)
		C2H2 Zn finger	212..232	CDD:275368	4/23 (17%)
		C2H2 Zn finger	240..260	CDD:275368	5/19 (26%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		COG5048	292..704	CDD:227381	113/381 (30%)
		C2H2 Zn finger	296..316	CDD:275368	8/19 (42%)
		C2H2 Zn finger	324..344	CDD:275368	5/21 (24%)
		C2H2 Zn finger	352..372	CDD:275368	8/20 (40%)
		C2H2 Zn finger	380..400	CDD:275368	4/19 (21%)
		C2H2 Zn finger	408..428	CDD:275368	1/19 (5%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	464..484	CDD:275368	4/19 (21%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	548..568	CDD:275368	9/19 (47%)
		C2H2 Zn finger	576..596	CDD:275368	8/19 (42%)
		C2H2 Zn finger	604..624	CDD:275368	6/20 (30%)
		C2H2 Zn finger	632..652	CDD:275368	0/19 (0%)
		C2H2 Zn finger	660..680	CDD:275368	139/487 (29%)
		C2H2 Zn finger	688..708	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010