DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF583

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_005258615.1	Gene:	ZNF583 / 147949	HGNCID:	26427	Length:	570	Species:	Homo sapiens

Alignment Length:	527	Identity:	140/527 - (26%)
Similarity:	218/527 - (41%)	Gaps:	125/527 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 HIYDKIDASSLEDD---------EIGQEDL----------EPAEEHQETETTKPTTTVSAETQPN 134
            |:...:|..||.:|         ::|.:::          |...|.|..|..|...|...:|
Human   109 HLSYSLDYPSLREDCQSEDWYKNQLGSQEVHLSQLIITHKEILPEVQNKEYNKSWQTFHQDT--- 170

  Fly   135 NTASDPIEIFVDAVDIDEA----EEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRP 195
                    ||    ||.::    |:..:.|.|::.|.::..|                    ::.
Human   171 --------IF----DIQQSFPTKEKAHKHEPQKKSYRKKSVE--------------------MKH 203

  Fly   196 QENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRH 260
            ::.|..::||              .|.:||..|..::|.|:|.:....||.:||..|||.:....
Human   204 RKVYVEKKLL--------------KCNDCEKVFNQSSSLTLHQRIHTGEKPYACVECGKTFSQSA 254

  Fly   261 NLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEA 325
            ||..|...:..|..:||..|.|.|.....|..|.:.|..::.::|:.  |::.|....||..|:.
Human   255 NLAQHKRIHTGEKPYECKECRKAFSQNAHLAQHQRVHTGEKPYQCKE--CKKAFSQIAHLTQHQR 317

  Fly   326 THSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFAS----YAEKRIHMLE 386
            .|:|   .:...|..|||.|.:...|..| .|.|.|||||.|..|.:.|:.    ...:|||..|
Human   318 VHTG---ERPFECIECGKAFSNGSFLAQH-QRIHTGEKPYVCNVCGKAFSHRGYLIVHQRIHTGE 378

  Fly   387 RHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQC 451
            |         ..||..||:.||....|..|......::|                       ::|
Human   379 R---------PYECKECRKAFSQYAHLAQHQRVHTGEKP-----------------------YEC 411

  Fly   452 GSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFA 516
            ..|.:.|:..:.|::|..||: .::|:.|..|.|.|..:..:..|.::|..|||.:|..|.|.|:
Human   412 KVCRKAFSQIAYLDQHQRVHT-GEKPYECIECGKAFSNSSSLAQHQRSHTGEKPYMCKECRKTFS 475

  Fly   517 LKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTH 581
            ....|.||:..| ..||.::|||||:|:.:..||.||||.|||:..|:|..|::.|
Human   476 QNAGLAQHQRIH-TGEKPYECNVCGKAFSYSGSLTLHQRIHTGERPYECKDCRKSF--------- 530

  Fly   582 MQKAHAA 588
            .|:||.|
Human   531 RQRAHLA 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	85/313 (27%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	12/19 (63%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
ZNF583	XP_005258615.1	C2H2 Zn finger	355..375	CDD:275368	4/19 (21%)
		zf-H2C2_2	367..392	CDD:290200	10/33 (30%)
		C2H2 Zn finger	383..403	CDD:275368	7/19 (37%)
		zf-H2C2_2	395..420	CDD:290200	6/47 (13%)
		C2H2 Zn finger	411..431	CDD:275368	5/19 (26%)
		zf-H2C2_2	423..448	CDD:290200	9/25 (36%)
		C2H2 Zn finger	439..459	CDD:275368	5/19 (26%)
		zf-H2C2_2	451..476	CDD:290200	9/24 (38%)
		C2H2 Zn finger	467..487	CDD:275368	7/19 (37%)
		zf-H2C2_2	480..504	CDD:290200	12/24 (50%)
		C2H2 Zn finger	495..515	CDD:275368	12/19 (63%)
		zf-H2C2_2	507..532	CDD:290200	13/33 (39%)
		C2H2 Zn finger	523..543	CDD:275368	7/24 (29%)
		KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		COG5048	210..543	CDD:227381	117/391 (30%)
		C2H2 Zn finger	215..235	CDD:275368	7/19 (37%)
		zf-H2C2_2	227..252	CDD:290200	10/24 (42%)
		C2H2 Zn finger	243..263	CDD:275368	7/19 (37%)
		zf-H2C2_2	255..280	CDD:290200	9/24 (38%)
		C2H2 Zn finger	271..291	CDD:275368	6/19 (32%)
		zf-H2C2_2	283..308	CDD:290200	6/26 (23%)
		C2H2 Zn finger	299..319	CDD:275368	6/21 (29%)
		zf-H2C2_2	311..336	CDD:290200	10/27 (37%)
		C2H2 Zn finger	327..347	CDD:275368	8/20 (40%)
		zf-H2C2_2	340..364	CDD:290200	12/24 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100