DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8301 and ZNF420

DIOPT Version :9

Sequence 1:NP_649915.1 Gene:CG8301 / 41160 FlyBaseID:FBgn0037717 Length:607 Species:Drosophila melanogaster
Sequence 2:NP_001316444.1 Gene:ZNF420 / 147923 HGNCID:20649 Length:704 Species:Homo sapiens


Alignment Length:618 Identity:164/618 - (26%)
Similarity:230/618 - (37%) Gaps:168/618 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   107 EDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEE---------EEEEEQ 162
            :||.|.:...|||.::            ...||.:|    ..|::|:...         |:::|.
Human    54 KDLSPEKNTYETELSQ------------WEMSDRLE----NCDLEESNSRDYLEAKGKMEKQQEN 102

  Fly   163 QQQYDEE-------------------------VEEPI----------------------TDE--- 177
            |::|..:                         .|:|.                      |.|   
Human   103 QKEYFRQGMIIYDKMSIFNQHTYLSQHSRCHSTEKPYKCKECGKAFRRASHLTQHQSIHTGEKPY 167

  Fly   178 ---------SAPPQLTI---------SYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPEC 224
                     |...||::         .||||.|  .:...|..||:|.|  ..|..|:||.|.||
Human   168 ECKQCGKAFSRDSQLSLHQRLHTGEKPYACKEC--GKAFTQSSQLILHH--RIHTGEKPYKCEEC 228

  Fly   225 EARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDR-----HNLRHHVEKYH-------------- 270
            ...|..::..|.|.|....||.:.|..|||.:...     |...|..||.:              
Human   229 GKAFIRSSQLTRHQKVHTGEKPYECKECGKAFTQNSQLTLHQRLHTGEKLYECKECRKVFTQLSQ 293

  Fly   271 ---------SETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEAT 326
                     .|..:||..|.|.|.....|:.|.|.||.::.::|:.  |.|.||....||.|:..
Human   294 LILHKRIHTGEKPYECKECGKAFICGSQLSQHQKIHNGEKPYECKE--CGRAFIRGSLLMQHQRI 356

  Fly   327 HSGTSSRKSEHCG-------------------------FCGKTFIHLKTLRWHIYRQHGGEKPYK 366
            |:|....|.|.||                         .|||.|.|...|..| .|.|.|||||:
Human   357 HTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGKMFSHGSQLTQH-QRIHTGEKPYQ 420

  Fly   367 CANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRP------ 425
            |..|.:.|     .|..:|.||:...|..:..||..|.:.||...:|..|......::|      
Human   421 CKECGKAF-----NRGSLLTRHQRIHTGEKPYECKECGKTFSRGSELTQHERIHTGEKPYECKEC 480

  Fly   426 GAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRA 490
            |...| ...::.|.:|.......::|..|...|...|.|.:|..:|: .::|:.|..|.|.|.|.
Human   481 GKSFI-RGSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHT-GEKPYVCNECGKAFARG 543

  Fly   491 QDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQR 555
            ..:..|.:.|..|||..|..|||||.....||||:..| ..||.::|..||:|:.....|.||||
Human   544 LLLIQHQRIHTGEKPYQCKECGKAFIRGSQLTQHQRIH-TGEKPYECKECGKAFSHGSQLTLHQR 607

  Fly   556 THTGKTYYKCDLCQERFVTHIKLKTHMQKAHAA 588
            .|||:..|:|..|::.|.....|..| |:.|.|
Human   608 IHTGEKPYECRECRKAFTQSSHLSRH-QRIHTA 639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8301NP_649915.1 zf-AD 3..87 CDD:285071
COG5048 198..>508 CDD:227381 103/368 (28%)
C2H2 Zn finger 221..241 CDD:275368 7/19 (37%)
C2H2 Zn finger 249..269 CDD:275368 7/24 (29%)
C2H2 Zn finger 277..297 CDD:275368 7/19 (37%)
C2H2 Zn finger 305..327 CDD:275368 8/21 (38%)
C2H2 Zn finger 338..359 CDD:275368 10/45 (22%)
C2H2 Zn finger 367..384 CDD:275368 4/16 (25%)
C2H2 Zn finger 400..420 CDD:275368 6/19 (32%)
C2H2 Zn finger 451..471 CDD:275368 6/19 (32%)
C2H2 Zn finger 480..500 CDD:275368 6/19 (32%)
C2H2 Zn finger 508..528 CDD:275368 10/19 (53%)
C2H2 Zn finger 537..557 CDD:275368 9/19 (47%)
C2H2 Zn finger 565..582 CDD:275368 4/16 (25%)
ZNF420NP_001316444.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR24377
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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