DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF417

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_011524775.1	Gene:	ZNF417 / 147687	HGNCID:	20646	Length:	643	Species:	Homo sapiens

Alignment Length:	378	Identity:	104/378 - (27%)
Similarity:	166/378 - (43%)	Gaps:	73/378 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 YNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKR 283
            |.|.:|...|....|.:.|.:....:..:.||.|||.|..:.:|..|...:..:|.:.|..|.|.
Human   308 YVCSDCGKSFSRYVSFSNHQRDHTAKGPYDCGECGKSYSRKSSLIQHQRVHTGKTAYPCEECGKS 372

  Fly   284 FYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHL 348
            |..:.||..|.:.|..:|.::||..|  :.|..:.:|:.|:..|:|   .::.|||.|||:| ..
Human   373 FSQKGSLISHQRVHTGERPYECREYG--KSFGQKGNLIQHQQGHTG---ERAYHCGECGKSF-RQ 431

  Fly   349 KTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDL 413
            |....:..|.|.||:||||..                                 |.:.|..:.:|
Human   432 KFCFINHQRVHTGERPYKCGE---------------------------------CGKSFGQKGNL 463

  Fly   414 IHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPH 478
            :.|......:||                       ::|..|.:.|..:|.|..|..:|: .:||:
Human   464 VQHQRGHTGERP-----------------------YECKECGKSFRYRSHLTEHQRLHT-GERPY 504

  Fly   479 ACPHCSKRFKRAQDMKWHIKTHEK----EKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNV 539
            .|..|.|.|.|    |:|:..||:    |:|..|:||||.|..|..:|.|:..| ..|:.::||.
Human   505 NCRECGKLFNR----KYHLLVHERVHTGERPYACEVCGKLFGNKNCVTIHQRIH-TGERPYECNE 564

  Fly   540 CGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592
            ||:::|...:|.:|:|.|:|:..|||..|.:.|.....|..| ::.|...:|:
Human   565 CGKSFLSSSALHVHKRVHSGQKPYKCSECGKSFAECSSLIKH-RRIHTGERPY 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	74/292 (25%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	1/16 (6%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF417	XP_011524775.1	KRAB	83..138	CDD:214630
		KRAB	83..122	CDD:279668
		C2H2 Zn finger	162..182	CDD:275368
		C2H2 Zn finger	190..210	CDD:275368
		C2H2 Zn finger	282..302	CDD:275368
		C2H2 Zn finger	310..330	CDD:275368	5/19 (26%)
		C2H2 Zn finger	338..358	CDD:275368	8/19 (42%)
		COG5048	<341..636	CDD:227381	96/345 (28%)
		zf-C2H2	364..386	CDD:278523	7/21 (33%)
		C2H2 Zn finger	366..386	CDD:275368	7/19 (37%)
		C2H2 Zn finger	394..411	CDD:275368	5/18 (28%)
		C2H2 Zn finger	422..442	CDD:275368	8/20 (40%)
		zf-H2C2_2	437..457	CDD:290200	9/52 (17%)
		C2H2 Zn finger	450..470	CDD:275368	5/52 (10%)
		zf-H2C2_2	462..487	CDD:290200	7/47 (15%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		zf-H2C2_2	490..515	CDD:290200	9/25 (36%)
		C2H2 Zn finger	506..526	CDD:275368	9/23 (39%)
		zf-H2C2_2	518..541	CDD:290200	10/22 (45%)
		C2H2 Zn finger	534..554	CDD:275368	9/19 (47%)
		zf-H2C2_2	550..571	CDD:290200	7/21 (33%)
		C2H2 Zn finger	562..582	CDD:275368	8/19 (42%)
		zf-H2C2_2	577..598	CDD:290200	8/20 (40%)
		C2H2 Zn finger	590..610	CDD:275368	5/20 (25%)
		zf-H2C2_2	602..625	CDD:290200	4/16 (25%)
		C2H2 Zn finger	618..638	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100