DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF418

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001303956.1	Gene:	ZNF418 / 147686	HGNCID:	20647	Length:	697	Species:	Homo sapiens

Alignment Length:	376	Identity:	116/376 - (30%)
Similarity:	171/376 - (45%)	Gaps:	46/376 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 CKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCG 253
            |..|...:.|      |::| ...|..|:||.|.||...|....:.|.|.:....|:.:.||.||
Human   368 CGKCFTQKGN------LIQH-QRGHTSERPYECEECGKCFSQKGTLTEHHRVHTRERPYECGECG 425

  Fly   254 KKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQR 318
            |.:..:.:||:|...:..|..:||..|.|.|..:.:|..|.:.|..:|.::||.  |.:||..:.
Human   426 KSFSRKGHLRNHQRGHTGERPYECGECGKSFSRKGNLIQHQRSHTGERPYECRE--CRKLFRGKS 488

  Fly   319 HLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIH 383
            ||:.|:..|:|   .:...|..|||:|......|.| .|.|.||||::|:.|.:.|.....
Human   489 HLIEHQRVHTG---ERPYECNECGKSFQDSSGFRVH-QRVHTGEKPFECSECGKSFPQSCS---- 545

  Fly   384 MLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGL 448
             |.|||...|.....||..|.:.|.....|:.|......:||
Human   546 -LLRHRRVHTGERPYECGECGKSFHQSSSLLRHQKTHTAERP----------------------- 586

  Fly   449 FQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGK 513
            ::|..|.:.|   |:|..|..||: .:||:.|..|.|.|.|......|.:.|.:.||..|..|||
Human   587 YECRECGKFF---SSLLEHRRVHT-GERPYECRECGKTFTRRSAHFKHQRLHTRGKPYECSECGK 647

  Fly   514 AFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYK 564
            :||..:.||:||..| ..|:.::|:.||:::....||..|||.||.::.||
Human   648 SFAETFSLTEHRRVH-TGERPYECSECGKSFHRSSSLLRHQRVHTERSPYK 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	90/309 (29%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	8/21 (38%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	116/376 (31%)
ZNF418	NP_001303956.1	KRAB	26..>67	CDD:214630
		KRAB	26..65	CDD:279668
		C2H2 Zn finger	105..125	CDD:275368
		C2H2 Zn finger	253..273	CDD:275368
		C2H2 Zn finger	281..301	CDD:275368
		zf-H2C2_2	293..318	CDD:290200
		COG5048	304..692	CDD:227381	113/369 (31%)
		C2H2 Zn finger	309..329	CDD:275368
		zf-H2C2_2	321..346	CDD:290200
		C2H2 Zn finger	337..357	CDD:275368
		zf-H2C2_2	350..374	CDD:290200	2/5 (40%)
		C2H2 Zn finger	365..385	CDD:275368	5/23 (22%)
		C2H2 Zn finger	393..413	CDD:275368	6/19 (32%)
		C2H2 Zn finger	421..441	CDD:275368	8/19 (42%)
		zf-H2C2_2	433..458	CDD:290200	9/24 (38%)
		C2H2 Zn finger	449..469	CDD:275368	6/19 (32%)
		C2H2 Zn finger	477..497	CDD:275368	8/21 (38%)
		zf-H2C2_2	489..512	CDD:290200	9/25 (36%)
		C2H2 Zn finger	505..525	CDD:275368	8/20 (40%)
		zf-H2C2_2	518..540	CDD:290200	10/22 (45%)
		C2H2 Zn finger	533..553	CDD:275368	7/24 (29%)
		zf-H2C2_2	545..570	CDD:290200	9/29 (31%)
		C2H2 Zn finger	561..581	CDD:275368	5/19 (26%)
		zf-H2C2_2	573..598	CDD:290200	7/50 (14%)
		C2H2 Zn finger	589..606	CDD:275368	6/19 (32%)
		zf-H2C2_2	598..623	CDD:290200	10/25 (40%)
		C2H2 Zn finger	614..634	CDD:275368	6/19 (32%)
		C2H2 Zn finger	642..662	CDD:275368	10/19 (53%)
		zf-H2C2_2	654..679	CDD:290200	9/25 (36%)
		C2H2 Zn finger	670..690	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100