DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF534

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001137411.1	Gene:	ZNF534 / 147658	HGNCID:	26337	Length:	674	Species:	Homo sapiens

Alignment Length:	417	Identity:	121/417 - (29%)
Similarity:	182/417 - (43%)	Gaps:	60/417 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 RPQENYQLQQLLLEHINAS-----HDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCG 253
            :|..|.:..::...|...:     |..|:||.|.||...|...:|.|.||.....||.:.|..||
Human   281 KPYNNKECGKVFSHHAYLAQHRKIHTGEKPYKCSECGKAFSVCSSLTAHLVIHTGEKPYDCKECG 345

  Fly   254 KKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQR 318
            |.:..:.:|..|...:..|..::|..|.|.|.....|..|.|.|..::.:||..  |.::||...
Human   346 KVFRHKSSLTTHQTVHTGERPYKCNECGKGFSRIAFLARHRKVHTGEKPYKCNE--CGKVFIGNS 408

  Fly   319 HLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIH 383
            .|..|...|:|....|   |..|||.|.....|..|:. .|.|||||:|.:|.:||
Human   409 RLARHRKIHTGGRRYK---CNECGKAFRTCSDLTAHLL-IHTGEKPYECIDCGKVF--------- 460

  Fly   384 MLERHRENLT---AIERSE----CMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKR 441
               ||:.:||   .|...|    |..|.:.||...:|                         |:.
Human   461 ---RHKSSLTYHCRIHTGEKPYKCNECGKVFSQNSNL-------------------------QRH 497

  Fly   442 ERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEK 504
            .:.::|  |::|..|.:.|...|.|.:|..:|: .::|::|..|.|.|:|...:..|...|..||
Human   498 RKIHTGEKLYKCNECGKVFRQNSHLAQHRDIHT-GEKPYSCNECGKVFRRNSHLVRHRNVHTGEK 561

  Fly   505 PNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQ 569
            |..|:.|||.|:....|.:||..| ..||...||.||:.:.....|..|::.|||:..|||:.|.
Human   562 PYSCNECGKVFSRNSHLARHRNIH-TGEKPHSCNECGKVFSRNSHLARHRKIHTGEKLYKCNECS 625

  Fly   570 ERFVTHIKLKTHMQKAHAASQPHSADQ 596
            :.|..:.:|..| :..|...:|:|.::
Human   626 KVFSRNSRLAQH-RNIHTGVKPYSCNE 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	90/323 (28%)
		C2H2 Zn finger	221..241	CDD:275368	8/19 (42%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF534	NP_001137411.1	KRAB	8..81	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	201..221	CDD:275368
		COG5048	211..609	CDD:227381	107/372 (29%)
		C2H2 Zn finger	229..249	CDD:275368
		zf-H2C2_2	241..266	CDD:290200
		C2H2 Zn finger	258..277	CDD:275368
		C2H2 Zn finger	286..305	CDD:275368	1/18 (6%)
		zf-H2C2_2	297..321	CDD:290200	7/23 (30%)
		C2H2 Zn finger	313..333	CDD:275368	8/19 (42%)
		C2H2 Zn finger	341..361	CDD:275368	6/19 (32%)
		zf-H2C2_2	353..378	CDD:290200	7/24 (29%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		zf-H2C2_2	382..404	CDD:290200	7/23 (30%)
		C2H2 Zn finger	397..417	CDD:275368	6/21 (29%)
		C2H2 Zn finger	425..445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	453..473	CDD:275368	8/31 (26%)
		zf-H2C2_2	465..490	CDD:290200	7/24 (29%)
		C2H2 Zn finger	481..501	CDD:275368	6/44 (14%)
		zf-H2C2_2	493..518	CDD:290200	7/49 (14%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		zf-H2C2_2	521..546	CDD:290200	8/25 (32%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		zf-H2C2_2	549..574	CDD:290200	10/24 (42%)
		C2H2 Zn finger	565..585	CDD:275368	8/19 (42%)
		zf-H2C2_2	577..602	CDD:290200	10/25 (40%)
		C2H2 Zn finger	593..613	CDD:275368	6/19 (32%)
		zf-H2C2_2	605..630	CDD:290200	10/24 (42%)
		C2H2 Zn finger	621..641	CDD:275368	5/20 (25%)
		C2H2 Zn finger	649..669	CDD:275368	0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100