DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF480

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_653285.2	Gene:	ZNF480 / 147657	HGNCID:	23305	Length:	535	Species:	Homo sapiens

Alignment Length:	496	Identity:	134/496 - (27%)
Similarity:	203/496 - (40%)	Gaps:	91/496 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 GQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPI---------------EIFVDAVDIDEAE 154
            |:.:::.|:.....|..|...|.|:....:|....||               |:|.|...|:...
Human    88 GESEVKIAKNSDGRECIKGVNTGSSYALGSNAEDKPIKKQLGVSFHLHLSELELFPDERVINGCN 152

  Fly   155 EEEEEEEQQ------QQYDEEVEEPI-----TDESAPPQLTISYACKFCLRPQENYQLQQLLLEH 208
            :.|......      |:....|:.||     .|:|:             ..|||    |::
Human   153 QVENFINHSSSVSCLQEMSSSVKTPIFNRNDFDDSS-------------FLPQE----QKV---- 196

  Fly   209 INASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSET 273
                |..|:||.|.|....|:.::|.|.|.....|||.:.|..|||.:....:|..|...:..|.
Human   197 ----HLREKPYECNEHSKVFRVSSSLTKHQVIHTVEKPYKCNSCGKVFSRNSHLAEHCRIHTGEK 257

  Fly   274 DFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHC 338
            .::|.:|.|.|....:...|.:.|..::.::|..  |.::|.:..:|..|:..|   :..|...|
Human   258 PYKCNVCGKVFSYNSNFARHQRIHTREKPYECNE--CGKVFSNNSYLARHQRIH---AEEKPYKC 317

  Fly   339 GFCGKTFIHLKTL--RWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECM 401
            ..|||.|.|..:|  .|.||.   |||||||..|.:.|     .||.:|.||::..|..:..:|.
Human   318 NECGKGFSHKSSLANHWRIYT---GEKPYKCDECGKAF-----YRIALLVRHQKIHTGEKPYKCN 374

  Fly   402 LCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALER 466
            .|.:.|.....|..|......::|                       ::|..|.:.||..|.|.|
Human   375 ECGKVFIQNSHLAQHWRIHTGEKP-----------------------YKCNECGKVFNQLSNLAR 416

  Fly   467 HAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVL 531
            |..:|: .::|:.|..|.|.|.....:..|:..|..|||..|..|||||..|..||.|:..| ..
Human   417 HRRIHT-GEKPYKCNECGKAFSEYSGLSAHLVIHTGEKPYKCSECGKAFRHKLSLTNHQRIH-TG 479

  Fly   532 EKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERF 572
            |:.:|||.||:.:.....|..|::.|||:..|||:.|.:.|
Human   480 ERPYKCNECGKVFNRIAHLARHRKIHTGEKPYKCNECGKAF 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	84/311 (27%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	10/22 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	3/8 (38%)
ZNF480	NP_653285.2	KRAB	27..87	CDD:214630
		KRAB	27..66	CDD:279668
		COG5048	<158..501	CDD:227381	111/405 (27%)
		C2H2 Zn finger	205..225	CDD:275368	6/19 (32%)
		zf-H2C2_2	217..242	CDD:290200	10/24 (42%)
		C2H2 Zn finger	233..253	CDD:275368	6/19 (32%)
		zf-H2C2_2	245..270	CDD:290200	7/24 (29%)
		C2H2 Zn finger	261..281	CDD:275368	5/19 (26%)
		zf-H2C2_2	273..298	CDD:290200	5/26 (19%)
		C2H2 Zn finger	289..309	CDD:275368	5/21 (24%)
		zf-H2C2_2	301..326	CDD:290200	9/27 (33%)
		C2H2 Zn finger	317..336	CDD:275368	8/18 (44%)
		C2H2 Zn finger	345..365	CDD:275368	8/24 (33%)
		zf-H2C2_2	358..382	CDD:290200	7/23 (30%)
		C2H2 Zn finger	373..393	CDD:275368	5/19 (26%)
		zf-H2C2_2	385..410	CDD:290200	6/47 (13%)
		zf-C2H2	399..421	CDD:278523	8/21 (38%)
		C2H2 Zn finger	401..421	CDD:275368	8/19 (42%)
		zf-H2C2_2	413..437	CDD:290200	8/24 (33%)
		C2H2 Zn finger	429..449	CDD:275368	5/19 (26%)
		zf-H2C2_2	442..466	CDD:290200	11/23 (48%)
		C2H2 Zn finger	457..477	CDD:275368	10/19 (53%)
		zf-H2C2_2	469..494	CDD:290200	10/25 (40%)
		COG5048	481..>529	CDD:227381	15/40 (38%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		zf-H2C2_2	497..522	CDD:290200	10/24 (42%)
		C2H2 Zn finger	513..533	CDD:275368	3/8 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100