DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZFP28

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_065879.1	Gene:	ZFP28 / 140612	HGNCID:	17801	Length:	868	Species:	Homo sapiens

Alignment Length:	544	Identity:	145/544 - (26%)
Similarity:	222/544 - (40%)	Gaps:	101/544 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 KIDASSLEDD-----------EIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVD 146
            |:|.||..::           .:|||    .:..||..|...|.:...|...|.:.    ..|.
Human   329 KLDCSSFRENWDSDYVFGRKLAVGQE----TQFRQEPITHNKTLSKERERTYNKSG----RWFY- 384

  Fly   147 AVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYA------CKFCLRPQENYQLQQLL 205
               :|::||:....:..:.:.:        .|...:.|..||      |..|   ::.:.....|
Human   385 ---LDDSEEKVHNRDSIKNFQK--------SSVVIKQTGIYAGKKLFKCNEC---KKTFTQSSSL 435

  Fly   206 LEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYH 270
            ..| ...|..|:||.|.||...|.|.:|...|.:....:|.:.|..|||.:....:|..|...||
Human   436 TVH-QRIHTGEKPYKCNECGKAFSDGSSFARHQRCHTGKKPYECIECGKAFIQNTSLIRHWRYYH 499

  Fly   271 S-ETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRK 334
            : |..|:|..|.|.|.....||.|.:.|..::.:||  ..|.:.|.....|..|:..|:|   .|
Human   500 TGEKPFDCIDCGKAFSDHIGLNQHRRIHTGEKPYKC--DVCHKSFRYGSSLTVHQRIHTG---EK 559

  Fly   335 SEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVF------ASYAEKRIH---------- 383
            ...|..|.|.|.|..:|..| .|.|.||||:||..|.:.|      ||:.  |||
Human   560 PYECDVCRKAFSHHASLTQH-QRVHSGEKPFKCKECGKAFRQNIHLASHL--RIHTGEKPFECAE 621

  Fly   384 ---------MLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQ 439
                     .|..|:...|..:..||.:|.:.|:.:..|..|......::|
Human   622 CGKSFSISSQLATHQRIHTGEKPYECKVCSKAFTQKAHLAQHQKTHTGEKP-------------- 672

  Fly   440 KRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEK 504
                     ::|..|.:.|:..:.|.:|..||: .::|:.|..|.|.|........|.:.|..::
Human   673 ---------YECKECGKAFSQTTHLIQHQRVHT-GEKPYKCMECGKAFGDNSSCTQHQRLHTGQR 727

  Fly   505 PNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQ 569
            |..|..|||||..|..|..||.|| ..||.::|:|||:|:...:||.:|||.|:||..|:|..|:
Human   728 PYECIECGKAFKTKSSLICHRRSH-TGEKPYECSVCGKAFSHRQSLSVHQRIHSGKKPYECKECR 791

  Fly   570 ERFVTHIKLKTHMQKAHAASQPHS 593
            :.|:....|..| ::.|...:.::
Human   792 KTFIQIGHLNQH-KRVHTGERSYN 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	88/335 (26%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	8/41 (20%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	10/19 (53%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZFP28	NP_065879.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..82
		KRAB	103..163	CDD:214630
		KRAB	103..142	CDD:279668
		KRAB	232..288	CDD:214630
		KRAB	232..266	CDD:279668
		COG5048	417..806	CDD:227381	123/426 (29%)
		zf-C2H2	420..442	CDD:278523	4/25 (16%)
		C2H2 Zn finger	422..442	CDD:275368	4/23 (17%)
		zf-H2C2_2	434..458	CDD:290200	9/24 (38%)
		C2H2 Zn finger	450..470	CDD:275368	7/19 (37%)
		zf-H2C2_2	462..487	CDD:290200	7/24 (29%)
		C2H2 Zn finger	478..496	CDD:275368	6/17 (35%)
		C2H2 Zn finger	507..527	CDD:275368	7/19 (37%)
		zf-H2C2_2	520..544	CDD:290200	8/25 (32%)
		C2H2 Zn finger	535..555	CDD:275368	5/21 (24%)
		zf-H2C2_2	547..572	CDD:290200	9/27 (33%)
		C2H2 Zn finger	563..583	CDD:275368	8/20 (40%)
		zf-H2C2_2	575..600	CDD:290200	12/25 (48%)
		C2H2 Zn finger	591..611	CDD:275368	6/21 (29%)
		zf-H2C2_2	603..627	CDD:290200	5/25 (20%)
		C2H2 Zn finger	619..639	CDD:275368	2/19 (11%)
		zf-H2C2_2	632..656	CDD:290200	7/23 (30%)
		C2H2 Zn finger	647..667	CDD:275368	5/19 (26%)
		zf-H2C2_2	659..684	CDD:290200	6/47 (13%)
		C2H2 Zn finger	675..695	CDD:275368	5/19 (26%)
		zf-H2C2_2	687..710	CDD:290200	8/23 (35%)
		C2H2 Zn finger	703..723	CDD:275368	5/19 (26%)
		zf-H2C2_2	718..740	CDD:290200	9/21 (43%)
		C2H2 Zn finger	731..751	CDD:275368	10/19 (53%)
		zf-H2C2_2	743..768	CDD:290200	12/25 (48%)
		C2H2 Zn finger	759..779	CDD:275368	10/19 (53%)
		zf-H2C2_2	771..796	CDD:290200	12/24 (50%)
		C2H2 Zn finger	787..807	CDD:275368	5/20 (25%)
		C2H2 Zn finger	815..835	CDD:275368	145/544 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100