DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and AgaP_AGAP011403

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_317913.2	Gene:	AgaP_AGAP011403 / 1278284	VectorBaseID:	AGAP011403	Length:	435	Species:	Anopheles gambiae

Alignment Length:	567	Identity:	113/567 - (19%)
Similarity:	181/567 - (31%)	Gaps:	246/567 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LKISPNDGLPQKICSDCFTKFCSINAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEE 114
            :||:....:...||..|..|......||..|    |....:::.:....:...| |.:.:|...|
Mosquito    41 IKINVKGNISYAICFACTQKLTVSAKFRQCC----LNNDALFEVLSGVLIASTE-GLQSVEAVGE 100

  Fly   115 HQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEE---------EQQQQYDEEV 170
            ..:::        .|.|..::...|        .:.::..|||:|.         :|:..|..:.
Mosquito   101 KSDSQ--------QAATDDDDDDDD--------YEYEQVYEEEDESVFKRADGTGQQEYSYTHQE 149

  Fly   171 EEPITDES---------------------------APPQL-------------------TISYAC 189
            ||..:|.|                           |.|.|                   :.|.|.
Mosquito   150 EESDSDTSYVEPADYSANYIDPGTQSDSDECGNPGAGPILYKWSVVQRAAAASTVEHDDSSSQAS 214

  Fly   190 KFC-LRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVE-KQHACGVC 252
            :.| :|.:::|:.|||                |..|.   :...|.:||..|.|.: :.|||..|
Mosquito   215 EICTMRTRKSYKQQQL----------------CTICG---KLVTSLSVHTNSVHKQARVHACPHC 260

  Fly   253 GKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQ 317
            .....::.||..||...|.:
Mosquito   261 PIAMTNKGNLVKHVRAVHLK--------------------------------------------- 280

  Fly   318 RHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHG-GEKPYKCANCTEVFASYAEKR 381
              |:|             |.|..|||.:.:..:|:.|:..||| |
Mosquito   281 --LLC-------------ERCKLCGKGYTNRNSLKSHMLAQHGIG-------------------- 310

  Fly   382 IHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYS 446
                          ||::|.||.:.|:.:..|..||...|          :|.|.|
Mosquito   311 --------------ERAKCKLCPKQFNQKSALHDHMKRIH----------SNVRPL--------- 342

  Fly   447 GLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVC 511
               :|..|.::|.::.||..|.:|||: ::|:||..|.||||.......|.:||.
Mosquito   343 ---ECDICGKQFKVRRALRVHKSVHSD-EQPYACGKCPKRFKSRHACNIHERTHS---------- 393

  Fly   512 GKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLH-QRTH 557
                             .||   |||::|||:|.::..|.:| ::||
Mosquito   394 -----------------GVL---FKCDLCGRSYRYKSLLNMHLRKTH 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	10/36 (28%)
		COG5048	198..>508	CDD:227381	66/311 (21%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	0/19 (0%)
		C2H2 Zn finger	305..327	CDD:275368	2/21 (10%)
		C2H2 Zn finger	338..359	CDD:275368	6/20 (30%)
		C2H2 Zn finger	367..384	CDD:275368	0/16 (0%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	0/19 (0%)
		C2H2 Zn finger	537..557	CDD:275368	7/20 (35%)
		C2H2 Zn finger	565..582	CDD:275368
AgaP_AGAP011403	XP_317913.2	zf-AD	7..79	CDD:214871	10/41 (24%)
		C2H2 Zn finger	231..249	CDD:275368	6/20 (30%)
		C2H2 Zn finger	257..278	CDD:275368	6/20 (30%)
		C2H2 Zn finger	286..307	CDD:275368	6/20 (30%)
		C2H2 Zn finger	315..336	CDD:275368	7/20 (35%)
		C2H2 Zn finger	344..364	CDD:275368	6/19 (32%)
		C2H2 Zn finger	372..392	CDD:275368	7/19 (37%)
		C2H2 Zn finger	399..420	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000098
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000