DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and AgaP_AGAP012768

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_307326.4	Gene:	AgaP_AGAP012768 / 1268757	VectorBaseID:	AGAP012768	Length:	419	Species:	Anopheles gambiae

Alignment Length:	479	Identity:	117/479 - (24%)
Similarity:	187/479 - (39%)	Gaps:	122/479 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 EPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEE-----EEEEQQQQYDEE 169
            |.|.||.|.|..:....|.|..:.........::.::..::...|:||     |.|:..|:..|.
Mosquito    11 EEAVEHHEEEIVEEFALVEASERLEQLIEQAEDVEIETQELSGEEDEETASSDEMEDGSQENAES 75

  Fly   170 VEEP----ITDESA------PPQLTISYACKFCLRPQEN------------YQ-------LQQLL 205
            .:|.    :.|||.      ||..|...:.:.....|.|            ||       :...|
Mosquito    76 GDESGTNNLLDESTDSVENNPPARTRRLSSRSARSAQTNDATRSRRKADHHYQHCDACGKMVSDL 140

  Fly   206 LEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHV-EKQHACGVCGKKYGDRHNLRHHVEKY 269
            ..|: .||..|:.::||.|.......::..:|:|:.|: |...:|.:||:.:.:.::.::|:...
Mosquito   141 KSHM-LSHTKEKRFSCPYCAVTMTFKSNLNIHIKTVHLKEISKSCELCGQGFVNYNSYKNHMASQ 204

  Fly   270 HSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRK 334
            |...::.|..|.|||...::.|.|::.|                         |:|  ..|..:|
Mosquito   205 HGTGEYSCETCAKRFTHLRTYNMHVRRH-------------------------HKA--DATYKKK 242

  Fly   335 SEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERS- 398
            .:.||.||....|:.|   |:. .|..||.|.|.:|.          |.|::  |.||....||
Mosquito   243 KQLCGTCGAMVTHIAT---HML-THTQEKRYACPHCP----------IEMVD--RGNLMRHVRSL 291

  Fly   399 ---------ECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSC 454
                     :|.:|.:.|:....|..|::..|          :|:|            .|:|.:|
Mosquito   292 RVHGIGKTFDCHMCAKKFNHNSGLKSHIARVH----------SNER------------KFECETC 334

  Fly   455 SQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNV---CDVCGKAFA 516
            ...|.:|.||.:|..||| .::|:||..|.||||.......|..||.    .:   |..|.|::.
Mosquito   335 GMLFKVKVALTKHQLVHS-TEQPYACNQCPKRFKSRHGRNSHQLTHS----GIVFPCPHCEKSYR 394

  Fly   517 LKYVLTQH-RLSHEVL--EKNFKC 537
            .|.||..| |.:|...  ||:..|
Mosquito   395 YKDVLGIHIRQNHPEAKEEKSIAC 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	82/342 (24%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	4/19 (21%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	2/21 (10%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	8/20 (40%)
		C2H2 Zn finger	537..557	CDD:275368	1/1 (100%)
		C2H2 Zn finger	565..582	CDD:275368
AgaP_AGAP012768	XP_307326.4	PRK02224	<26..>78	CDD:179385	9/51 (18%)
		C2H2 Zn finger	130..147	CDD:275368	2/17 (12%)
		C2H2 Zn finger	155..176	CDD:275368	5/20 (25%)
		C2H2 Zn finger	184..201	CDD:275368	3/16 (19%)
		C2H2 Zn finger	212..263	CDD:275368	19/81 (23%)
		C2H2 Zn finger	271..289	CDD:275368	7/29 (24%)
		SFP1	<289..380	CDD:227516	31/113 (27%)
		C2H2 Zn finger	302..323	CDD:275368	5/20 (25%)
		C2H2 Zn finger	331..351	CDD:275368	7/19 (37%)
		C2H2 Zn finger	359..379	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..404	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000098
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000