DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF573

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001166161.1	Gene:	ZNF573 / 126231	HGNCID:	26420	Length:	665	Species:	Homo sapiens

Alignment Length:	537	Identity:	150/537 - (27%)
Similarity:	229/537 - (42%)	Gaps:	95/537 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 NTASDPIEIFVDAVDIDEAEEEE----EEEEQQQQYDEE------VEEPI--TDESAPPQLTI-- 185
            ::.|.|:     .||:.|..:|.    .||.|....|.:      :|.|.  ||.|:....:|
Human    70 HSISKPV-----VVDLLERGKEPWMILREETQFTDLDLQCEIISYIEVPTYETDISSTQLQSIYK 129

  Fly   186 ---SYACKFCLRPQENYQL-QQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQ 246
               .|.||.|   |:.:.. .||:|.|  ..|..|:||.|.||...|:.....|:|.:....||.
Human   130 REKLYECKKC---QKKFSSGYQLILHH--RFHVIERPYECKECGKNFRSGYQLTLHQRFHTGEKP 189

  Fly   247 HACGVCGKKYGDRHNLRHHVEKYHS-ETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGC 310
            :.|..|||.:...:.|..| :::|: |..:||..|.|.|.....:..|.:.|...:.::|:.  |
Human   190 YECTECGKNFRSGYQLTVH-QRFHTGEKTYECRQCGKAFIYASHIVQHERIHTGGKPYECQE--C 251

  Fly   311 ERLFISQRHLMCHEATHSG-----------TSSRKS---EH-----------CGFCGKTFIHLKT 350
            .|.|....||..|:..|:|           |.||:|   ||           |..|||.|.....
Human   252 GRAFSQGGHLRIHQRVHTGEKPYKCKECGKTFSRRSNLVEHGQFHTDEKPYICEKCGKAFRRGHQ 316

  Fly   351 LRWHIYRQHGGEKPYKCANCTEVF--ASY--AEKRIHM-------------------LERHRENL 392
            |..| .|.|.|:|||:|..|.:.:  |||  ..:|||.                   |.||:...
Human   317 LTVH-QRVHTGKKPYECKECGKGYTTASYFLLHQRIHKGGKPYECKECKKTFTLYRNLTRHQNIH 380

  Fly   393 TAIERSECMLCRQPFSSEPDLIHHMSAEHLQRP------GAPIIANNKRVLQQKRERQYSGL--F 449
            |..:..||..|.:.:::...|..|......::|      |.   |.:.....::.::.::|:  |
Human   381 TGEKLFECKQCGKTYTTGSKLFQHQKTHTGEKPYECKECGK---AFSLYGYLKQHQKIHTGMKHF 442

  Fly   450 QCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKA 514
            :|..|.:.|.:...|.||..:|:.| :...|..|.|.:....::..|.|||..|||..|..|||.
Human   443 ECKECKKTFTLYRNLTRHQNIHTGK-KLFECQECGKAYSTGSNLIQHRKTHTGEKPYKCKECGKT 506

  Fly   515 FALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLK 579
            |:|...|.||:..|..: |.::|.||.:.:.|.::|.|||..||.:..::|..|.:.|.....|.
Human   507 FSLHGYLNQHQKIHTGM-KPYECKVCRKTFTFYRNLTLHQSIHTDEKPFECKECGKTFRRSSHLT 570

  Fly   580 THMQKAHAASQPHSADQ 596
            .| |..||..:|:...:
Human   571 AH-QSIHADKKPYECKE 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	99/367 (27%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	7/20 (35%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF573	NP_001166161.1	KRAB	28..89	CDD:214630	6/23 (26%)
		KRAB	28..67	CDD:279668
		C2H2 Zn finger	136..156	CDD:275368	8/24 (33%)
		C2H2 Zn finger	164..184	CDD:275368	6/19 (32%)
		C2H2 Zn finger	192..212	CDD:275368	6/20 (30%)
		C2H2 Zn finger	220..240	CDD:275368	5/19 (26%)
		COG5048	244..628	CDD:227381	98/352 (28%)
		C2H2 Zn finger	248..268	CDD:275368	7/21 (33%)
		zf-H2C2_2	260..285	CDD:290200	6/24 (25%)
		C2H2 Zn finger	276..292	CDD:275368	4/15 (27%)
		C2H2 Zn finger	304..324	CDD:275368	8/20 (40%)
		C2H2 Zn finger	332..352	CDD:275368	6/19 (32%)
		C2H2 Zn finger	360..380	CDD:275368	3/19 (16%)
		C2H2 Zn finger	388..408	CDD:275368	4/19 (21%)
		zf-H2C2_2	401..424	CDD:290200	5/25 (20%)
		C2H2 Zn finger	416..436	CDD:275368	2/22 (9%)
		C2H2 Zn finger	444..464	CDD:275368	6/19 (32%)
		C2H2 Zn finger	472..492	CDD:275368	5/19 (26%)
		zf-H2C2_2	484..508	CDD:290200	11/23 (48%)
		C2H2 Zn finger	500..520	CDD:275368	9/19 (47%)
		zf-H2C2_2	512..536	CDD:290200	8/24 (33%)
		C2H2 Zn finger	528..548	CDD:275368	8/19 (42%)
		C2H2 Zn finger	556..576	CDD:275368	6/20 (30%)
		C2H2 Zn finger	584..604	CDD:275368	0/3 (0%)
		zf-H2C2_2	596..621	CDD:290200
		C2H2 Zn finger	612..632	CDD:275368
		zf-H2C2_2	624..649	CDD:290200
		C2H2 Zn finger	640..660	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100