DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF813

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001004301.2	Gene:	ZNF813 / 126017	HGNCID:	33257	Length:	617	Species:	Homo sapiens

Alignment Length:	411	Identity:	130/411 - (31%)
Similarity:	187/411 - (45%)	Gaps:	43/411 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 YACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGV 251
            |.|..|   .:.:..::.|:.| ...|..|:||.|.||...|....|.|.|.:....||.:.|..
Human   243 YKCDVC---GKVFNRKRNLVCH-RRCHTGEKPYRCNECGKTFSQTYSLTCHRRLHTGEKPYKCEE 303

  Fly   252 CGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFIS 316
            |.|.:..:.||:.|...:..|..::|..|.|.|....||..|.:.|..::.|||..  |.:.|..
Human   304 CDKAFSFKSNLKRHRRIHAGEKPYKCNECGKTFSQTSSLTCHRRLHTGEKPFKCNE--CGKTFSR 366

  Fly   317 QRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKR 381
            :..|.||...|:|   .|...|..|||||....||:.| .|.|.|||||||..|.:||    .|:
Human   367 KSSLTCHHRLHTG---EKPYKCNECGKTFSQELTLKCH-RRLHTGEKPYKCNECGKVF----NKK 423

  Fly   382 IHMLERHRENLTAIERS-ECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQY 445
            .::...||  |.:.|:. :|..|.:.||....|:.| .|.|               :.:||
Human   424 ANLARHHR--LHSGEKPYKCTECVKTFSRNSALVIH-KAIH---------------IGEKR---- 466

  Fly   446 SGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDV 510
               ::|..|.:.|:..|||..|.|:|: .::|:.|..|.|.|.|...:..|.:.|..|||..|:.
Human   467 ---YKCNECGKTFSRISALVIHTAIHT-GEKPYKCNECGKGFNRKTHLACHHRLHTGEKPYKCNE 527

  Fly   511 CGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTH 575
            |||.|..|..|..|...| ..:|.:|||.||:.:..:..|..|.|.|||:..|||:.|.:.|...
Human   528 CGKVFNRKTHLAHHHRLH-TGDKPYKCNECGKVFNQKAHLARHHRLHTGEKPYKCNECGKVFNQK 591

  Fly   576 IKLKTHMQKAHAASQPHSADQ 596
            ..|..| .:.|...:|:..::
Human   592 ANLARH-HRLHTGEKPYKFNE 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	97/310 (31%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF813	NP_001004301.2	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	191..602	CDD:227381	128/400 (32%)
		C2H2 Zn finger	217..237	CDD:275368
		zf-H2C2_2	230..254	CDD:290200	3/13 (23%)
		C2H2 Zn finger	245..265	CDD:275368	4/23 (17%)
		zf-H2C2_2	257..282	CDD:290200	10/25 (40%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		zf-H2C2_2	285..309	CDD:290200	8/23 (35%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		zf-H2C2_2	313..338	CDD:290200	8/24 (33%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		zf-H2C2_2	341..366	CDD:290200	9/26 (35%)
		C2H2 Zn finger	357..377	CDD:275368	6/21 (29%)
		zf-H2C2_2	369..394	CDD:290200	12/27 (44%)
		C2H2 Zn finger	385..405	CDD:275368	10/20 (50%)
		zf-H2C2_2	398..421	CDD:290200	14/27 (52%)
		C2H2 Zn finger	413..433	CDD:275368	7/25 (28%)
		C2H2 Zn finger	441..461	CDD:275368	7/20 (35%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..517	CDD:275368	6/19 (32%)
		zf-H2C2_2	509..534	CDD:290200	10/24 (42%)
		C2H2 Zn finger	525..545	CDD:275368	8/19 (42%)
		C2H2 Zn finger	553..573	CDD:275368	7/19 (37%)
		zf-H2C2_2	565..590	CDD:290200	11/24 (46%)
		C2H2 Zn finger	581..601	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100